Zobrazeno 1 - 10
of 86
pro vyhledávání: '"Ian S. McLennan"'
Autor:
Zane B. Andrews, Hua Zhao, Tony Frugier, Reiko Meguro, David R. Grattan, Kyoko Koishi, Ian S. McLennan
Publikováno v:
Neurobiology of Disease, Vol 21, Iss 3, Pp 568-575 (2006)
The transforming growth factor-betas (TGF-βs) regulate the induction of dopaminergic neurons and are elevated in the CSF of Parkinson's patients. We report here that mice with TGF-β2 haploinsufficiency (TGF-β2+/−) have subclinical defects in the
Externí odkaz:
https://doaj.org/article/0807abedc9e24733a92bc715dd3e1f93
Publikováno v:
Neurobiology of Disease, Vol 19, Iss 1, Pp 323-330 (2005)
Amyotrophic lateral sclerosis (ALS) is fatal disorder, characterized by the loss of motoneurons. The therapeutic potential of transforming growth factor-beta 2 (TGF-β2) was examined using SOD1 mice. The SOD1 mice were treated with TGF-β2 by repeate
Externí odkaz:
https://doaj.org/article/20423ba0d7274caa881d7b42c7206e7a
Autor:
Yih Harng Chong, Nicola A. Dennis, Martin J. Connolly, Ruth Teh, Gregory T. Jones, Andre M. van Rij, Stephanie Farrand, A. John Campbell, Ian S. McLennan
Publikováno v:
PLoS ONE, Vol 8, Iss 10 (2013)
Externí odkaz:
https://doaj.org/article/9c25a958f789455e8b59186a2ae0382a
Publikováno v:
International Journal of Biological Sciences, Vol 6, Iss 6, Pp 546-555 (2010)
SMAD4 acts as the converging point for TGFβ and BMP signaling in heart development. Here, we investigated the role of SMAD4 in heart development using a novel α skeletal muscle actin Cre recombinase (MuCre) transgenic mouse strain. Lineage tracing
Externí odkaz:
https://doaj.org/article/71a5d23a1f074ef08e88201b582fa1d8
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e20533 (2011)
The testes of preadolescent boys appear to be dormant, as they produce only trace levels of testosterone. However, they release supra-adult levels of Müllerian Inhibiting Substance (MIS, anti-Müllerian hormone) and lesser levels of inhibin B (InhB)
Externí odkaz:
https://doaj.org/article/63f427c8ac03421a9893bb8fd9e2a169
Publikováno v:
Biology of Reproduction. 98:54-62
Anti-Mullerian hormone (AMH) is both a gonadal hormone and a putative paracrine regulator of neurons, the uterus, and the placenta. A mouse line with neuronal expression of AMH (Thy1.2-AMH) was generated to examine the role of paracrine AMH in the br
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc059b5b8a139b2a7df05975b887cb40
https://doi.org/10.1093/biolre/iox151
https://doi.org/10.1093/biolre/iox151
Publikováno v:
Endocrine. 57:528-534
High levels of circulating anti-Mullerian hormone are unique to developing males, but the function of anti-Mullerian hormone in boys is unknown. In mice, anti-Mullerian hormone contributes to the male biases in the brain, but its receptors are presen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bdd47422bbb58c800231f37a544273f
https://doi.org/10.1007/s12020-017-1333-2
https://doi.org/10.1007/s12020-017-1333-2
Publikováno v:
Molecular Reproduction and Development. 84:626-637
The hypothesis that, in contrast to other Transforming growth factor-beta (TGFβ) superfamily ligands, the dose-response curve of Anti-Mullerian hormone (AMH) is unmodulated was tested by examining whether known TGFB superfamily modulators affect AMH
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df8b77643634ee5f3371c3c24ff7364b
https://doi.org/10.1002/mrd.22828
https://doi.org/10.1002/mrd.22828
Publikováno v:
Endocrinology. 157:1622-1629
Anti-Müllerian hormone (AMH) is a gonadal hormone that regulates aspects of male sexual differentiation and ovarian function. AMH is synthesized as the AMH proprotein precursor (proAMH), which is converted to a receptor-binding form (AMHN,C) by prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e18897c81d51bd83dde3ebfb12803c4
https://doi.org/10.1210/en.2015-1834
https://doi.org/10.1210/en.2015-1834
Autor:
Michael W. Pankhurst, Ian S. McLennan
Publikováno v:
Molecular and Cellular Endocrinology. 419:165-171
The utility of serum anti-Müllerian hormone (AMH) assays in assessment of female fertility have been investigated extensively but little is known about the biological activity of the hormone being studied. ProAMH is the proprotein precursor and is i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39ef0b63080050fdc1794d0a2222f2c2
https://doi.org/10.1016/j.mce.2015.10.013
https://doi.org/10.1016/j.mce.2015.10.013