Zobrazeno 1 - 10
of 127
pro vyhledávání: '"Ian S McLennan"'
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0162509 (2016)
Circulating Anti-Müllerian hormone (AMH) is derived from the gonads, and is a mixture of the prohormone (proAMH), which does not bind to AMH receptors, and receptor-competent AMH. The functions of a hormone are partially defined by the factors that
Externí odkaz:
https://doaj.org/article/ba1c0d70801c42c3ad730baf9eacac50
Publikováno v:
International Journal of Biological Sciences, Vol 6, Iss 6, Pp 546-555 (2010)
SMAD4 acts as the converging point for TGFβ and BMP signaling in heart development. Here, we investigated the role of SMAD4 in heart development using a novel α skeletal muscle actin Cre recombinase (MuCre) transgenic mouse strain. Lineage tracing
Externí odkaz:
https://doaj.org/article/71a5d23a1f074ef08e88201b582fa1d8
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0133637 (2015)
The testes secrete four hormones (anti-Müllerian hormone, insulin-like peptide 3, Inhibin B and testosterone) from two endocrine cell types. It is unknown whether anti-Müllerian hormone and insulin-like peptide 3 levels have a diurnal variation, an
Externí odkaz:
https://doaj.org/article/ee28cf1f3c4b424bba8f62606ecf9ce9
Autor:
Zane B. Andrews, Hua Zhao, Tony Frugier, Reiko Meguro, David R. Grattan, Kyoko Koishi, Ian S. McLennan
Publikováno v:
Neurobiology of Disease, Vol 21, Iss 3, Pp 568-575 (2006)
The transforming growth factor-betas (TGF-βs) regulate the induction of dopaminergic neurons and are elevated in the CSF of Parkinson's patients. We report here that mice with TGF-β2 haploinsufficiency (TGF-β2+/−) have subclinical defects in the
Externí odkaz:
https://doaj.org/article/0807abedc9e24733a92bc715dd3e1f93
Publikováno v:
Neurobiology of Disease, Vol 19, Iss 1, Pp 323-330 (2005)
Amyotrophic lateral sclerosis (ALS) is fatal disorder, characterized by the loss of motoneurons. The therapeutic potential of transforming growth factor-beta 2 (TGF-β2) was examined using SOD1 mice. The SOD1 mice were treated with TGF-β2 by repeate
Externí odkaz:
https://doaj.org/article/20423ba0d7274caa881d7b42c7206e7a
Autor:
Yih Harng Chong, Nicola A Dennis, Martin J Connolly, Ruth Teh, Gregory T Jones, Andre M van Rij, Stephanie Farrand, A John Campbell, Ian S McLennan
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e70967 (2013)
The Sertoli cells of the testes secrete anti-Müllerian hormone (Müllerian inhibiting Substance, AMH) and inhibin B (InhB). AMH triggers the degeneration of the uterine precursor in male embryos, whereas InhB is part of the gonadal-pituitary axis fo
Externí odkaz:
https://doaj.org/article/d310b45684214bbd92a3a13bb35fc842
Autor:
Yih Harng Chong, Nicola A. Dennis, Martin J. Connolly, Ruth Teh, Gregory T. Jones, Andre M. van Rij, Stephanie Farrand, A. John Campbell, Ian S. McLennan
Publikováno v:
PLoS ONE, Vol 8, Iss 10 (2013)
Externí odkaz:
https://doaj.org/article/9c25a958f789455e8b59186a2ae0382a
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e58441 (2013)
Bone morphogenetic proteins (BMPs), members of the transforming growth factor-beta (TGF-β) superfamily, have been shown to play important roles in the nervous system, including neuronal survival and synaptogenesis. However, the physiological functio
Externí odkaz:
https://doaj.org/article/eab3057e9c034a008d83c90d6bce8e63
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e20533 (2011)
The testes of preadolescent boys appear to be dormant, as they produce only trace levels of testosterone. However, they release supra-adult levels of Müllerian Inhibiting Substance (MIS, anti-Müllerian hormone) and lesser levels of inhibin B (InhB)
Externí odkaz:
https://doaj.org/article/63f427c8ac03421a9893bb8fd9e2a169
Publikováno v:
Biology of Reproduction. 98:54-62
Anti-Mullerian hormone (AMH) is both a gonadal hormone and a putative paracrine regulator of neurons, the uterus, and the placenta. A mouse line with neuronal expression of AMH (Thy1.2-AMH) was generated to examine the role of paracrine AMH in the br
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc059b5b8a139b2a7df05975b887cb40
https://doi.org/10.1093/biolre/iox151
https://doi.org/10.1093/biolre/iox151