Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Ian Rowles"'
Autor:
Bruna Zuculoto da Costa, Carl Young, Ying Zhuo, Ashleigh J. Burke, Simon J. Charnock, Nicholas J. Turner, Anthony P. Green, William R. Birmingham, Thomas W. Thorpe, Rebecca Crawshaw, Ian Rowles, James Finnigan, Sarah L. Lovelock
The COVID-19 pandemic highlights the urgent need for cost-effective processes to rapidly manufacture antiviral drugs at scale. Here we report a concise biocatalytic process for Molnupiravir, a nucleoside analogue currently in phase 3 clinical trials
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65b8f19109e30db608bd4fd17b143b33
https://doi.org/10.26434/chemrxiv-2021-vfkqb-v3
https://doi.org/10.26434/chemrxiv-2021-vfkqb-v3
Autor:
Ashleigh Burke, William Birmingham, Ying Zhuo, Bruna Zuculoto da Costa, Rebecca Crawshaw, Thomas Thorpe, Ian Rowles, James Finnigan, Simon J. Charnock, Sarah Lovelock, Nicholas Turner, Anthony Green
The COVID-19 pandemic highlights the urgent need for cost-effective processes to rapidly manufacture antiviral drugs at scale. Here we report a concise biocatalytic process for Molnupiravir, a nucleoside analogue currently in phase 3 clinical trials
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3688f1a1f70c6dc1b5c614d2f6d2b91b
https://doi.org/10.26434/chemrxiv-2021-vfkqb-v2
https://doi.org/10.26434/chemrxiv-2021-vfkqb-v2
Autor:
Ashleigh Burke, William Birmingham, Ying Zhuo, Bruna Zuculoto da Costa, Rebecca Crawshaw, Thomas Thorpe, Ian Rowles, James Finnigan, Simon J. Charnock, Sarah Lovelock, Nicholas Turner, Anthony Green
Herein we report the conversion of cytidine 2 to N-hydroxycytidine 7 catalysed by cytidine deaminase (CD). The wild-type enzyme operates efficiently at high sustrate loadings and hydroxylamine concentrations to favor N-hydroxy-cytidine formation over
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bb54cbdd2a26ca1d112934b5480bd0e
https://doi.org/10.26434/chemrxiv.13721692
https://doi.org/10.26434/chemrxiv.13721692
Autor:
Verena Resch, Simon C. Willies, Bas Groenendaal, Barbara Grischek, Johann H. Sattler, Joerg H. Schrittwieser, Diego Ghislieri, Ian Rowles, Wolf-Dieter Lienhart, Nicholas J. Turner, Wolfgang Kroutil, Eva-Maria Fischereder
Publikováno v:
Catal. Sci. Technol.. 4:3657-3664
Chemo-enzymatic deracemisation was applied to obtain the (S)-enantiomer of 1-benzylisoquinolines from the racemate in high isolated yield (up to 85%) and excellent optical purity (ee > 97%). The one-pot deracemisation protocol encompassed enantiosele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f8c166c256f956cd7de35eaac48988db
https://doi.org/10.1039/c4cy00642a
https://doi.org/10.1039/c4cy00642a
Publikováno v:
ChemCatChem. 4:1259-1261
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a3b9fe9f0ec1c95c3dd8bcd29a6db06
https://doi.org/10.1002/cctc.201200202
https://doi.org/10.1002/cctc.201200202
Autor:
Simon C. Willies, Annika Frank, Nicholas J. Turner, Anthony P. Green, Diego Ghislieri, Gideon Grogan, Ian Rowles, Marta Pontini
Publikováno v:
Journal of the American Chemical Society. 135(29)
The development of cost-effective and sustainable catalytic methods for the production of enantiomerically pure chiral amines is a key challenge facing the pharmaceutical and fine chemical industries. This challenge is highlighted by the estimate tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a277bd87681eb13534486a999156b01
https://pubmed.ncbi.nlm.nih.gov/23808566
https://pubmed.ncbi.nlm.nih.gov/23808566
Autor:
Ashleigh J. Burke, William R. Birmingham, Ying Zhuo, Thomas W. Thorpe, Bruna Zucoloto da Costa, Rebecca Crawshaw, Ian Rowles, James D. Finnigan, Carl Young, Gregory M. Holgate, Mark P. Muldowney, Simon J. Charnock, Sarah L. Lovelock, Nicholas J. Turner, Anthony P. Green
Publikováno v:
Journal of the American Chemical Society. 144(9):3761-3765
The Covid-19 pandemic highlights the urgent need for cost-effective processes to rapidly manufacture antiviral drugs at scale. Here we report a concise biocatalytic process for Molnupiravir, a nucleoside analogue recently approved as an orally availa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82a537d5fb97b19c9e7a23e3bf6121ad