Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Ian Ross Harris"'
Human Umbilical Tissue-Derived Cells Secrete Soluble VEGFR1 and Inhibit Choroidal Neovascularization
Autor:
Gary W. McCollum, Rong Yang, John S. Penn, Ian Ross Harris, Steven C. Pomerantz, Theodore Petley, Stephanie M. Evans, Taylor E. Smith, Jing Cao
Publikováno v:
Molecular Therapy. Methods & Clinical Development
Exudative age-related macular degeneration (AMD), characterized by choroidal neovascularization (CNV), is the leading cause of irreversible blindness in developed countries. Anti-vascular endothelial growth factor (VEGF) drugs are the standard treatm
Publikováno v:
Circulation. 139:1228-1233
Publikováno v:
Journal of Translational Medicine, Vol 16, Iss 1, Pp 1-15 (2018)
Journal of Translational Medicine
Journal of Translational Medicine
Background Age-related macular degeneration (AMD) is a leading cause of blindness among the elderly characterized by retinal pigment epithelium (RPE) degeneration with accumulation of abnormal intracellular deposits (lipofuscin) and photoreceptor dea
Autor:
Gregory M. Marcus, Elyse Foster, Ian Ross Harris, Liviu Klein, Rima Arnaout, Punag Divanji, Zian H. Tseng, Nisha I. Parikh, Juan M. Gonzalez, Gregory Nah
BackgroundCardiovascular complications during and soon after pregnancy present an opportunity to assess risk for subsequent cardiovascular disease. We sought to determine whether peripartum cardiomyopathy and hypertensive disorder of pregnancy subtyp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78dbc79449b795c06ffecc3ead6556e0
Autor:
Ian Ross Harris
Publikováno v:
Biologicals. 43:402-405
The amount and type of data in regulatory submissions increases dramatically from the first-in-human clinical trials application through to the extensive dossier that is required for marketing authorization. The Pharmaceuticals and Biotechnology indu
Autor:
Sehwon Koh, Bin Lu, Ian Ross Harris, William J. Chen, Joshua Saylor, Cagla Eroglu, Shaomei Wang, Nadine Sophia Dejneka, Sergey Girman
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 38(12)
Human umbilical tissue-derived cells (hUTC or palucorcel) are currently under clinical investigation for the treatment of geographic atrophy, a late stage of macular degeneration, but how hUTC transplantation mediates vision recovery is not fully elu
Autor:
Anthony Ridgway, Nobuo Kanai, Yi-Chu Lin, James W. McBlane, Akihiro Umezawa, Paula Salmikangas, Matthias Renner, Yuzo Toda, Norihisa Sakamoto, Yoshiaki Maruyama, Michael Werner, Jeewon Joung, Yoji Sato, Srinivasan N. Kellathur, Stephen Wicks, Daisaku Sato, Ian Ross Harris, Takao Hayakawa, Junichi Koga, Shin Kawamata, Takuya Nishimura
Publikováno v:
Biologicals : journal of the International Association of Biological Standardization. 44(5)
The development of human cell therapy and gene therapy products has progressed internationally. Efforts have been made to address regulatory challenges in the evaluation of quality, efficacy, and safety of the products. In this forum, updates on the
Cell therapy demonstrates great potential for the treatment of neurological disorders. Human umbilical tissue-derived cells (hUTCs) were previously shown to have protective and regenerative effects in animal models of stroke and retinal degeneration,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30b9117d58a77fbe4189338f4e7dfbe4
https://europepmc.org/articles/PMC4659827/
https://europepmc.org/articles/PMC4659827/
Autor:
Ian Ross Harris, George Inana, Sandra Santulli-Marotto, Jing Cao, Weijun An, Lee John, Christopher Murat, Xiang Yao
Publikováno v:
Stem cells (Dayton, Ohio). 34(2)
Retinal pigment epithelium (RPE) cells perform many functions crucial for retinal preservation and vision. RPE cell dysfunction results in various retinal degenerative diseases, such as retinitis pigmentosa and age-related macular degeneration (AMD).
Autor:
Seymour Packman, Antonina Ryvlin, Ian Ross Harris, Kara Weisiger, Esra Gucuk Ipek, Rupesh Ranjan
Publikováno v:
Journal of the American College of Cardiology. 65(10)
Gaucher disease (GD) is an autosomal recessive disorder of lysosomal storage resulting in accumulation of glucosylceramide in various organs. Cardiovascular involvement is well recognized, but the complete spectrum of cardiovascular phenotypes has ne