Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Ian R. Pottie"'
Autor:
Sultan Darvesh, Scott Banfield, Maeve Dufour, Katrina L. Forrestall, Hillary Maillet, G. Andrew Reid, Dane Sands, Ian R. Pottie
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
Cholinesterase (ChE) enzymes have been identified as diagnostic markers for Alzheimer disease (AD). Substrate-based probes have been synthesised to detect ChEs but they have not detected changes in ChE distribution associated with AD pathology. Probe
Externí odkaz:
https://doaj.org/article/c958e74950c54e83ac55b4fa6fec5a01
Publikováno v:
Biomolecules, Vol 10, Iss 12, p 1608 (2020)
Kinetic studies and molecular modeling of human acetylcholinesterase (AChE) inhibition by a fluorinated acetophenone derivative, 1-(3-tert-butylphenyl)-2,2,2-trifluoroethanone (TFK), were performed. Fast reversible inhibition of AChE by TFK is of com
Externí odkaz:
https://doaj.org/article/2ef7c6ac1ddb47f0b77165ffe526b2e4
Publikováno v:
Canadian Journal of Chemistry. 99:801-811
COVID-19, caused by the severe acute respiratory coronavirus 2 (SARS-CoV-2), currently has no treatment for acute infection. The main protease (Mpro) of SARS-CoV-2 is an essential enzyme for viral replication and an attractive target for disease inte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::485c1ec5cf44893b6b1039824a640626
https://doi.org/10.1139/cjc-2021-0139
https://doi.org/10.1139/cjc-2021-0139
Publikováno v:
Chemico-Biological Interactions
The disease, COVID-19, is caused by the severe acute respiratory coronavirus 2 (SARS-CoV-2) for which there is currently no treatment. The SARS-CoV-2 main protease (Mpro) is an important enzyme for viral replication. Small molecules that inhibit this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e962420f9e16b525db7d429fa9e17db
Publikováno v:
Biomolecules
Volume 10
Issue 12
Biomolecules, Vol 10, Iss 1608, p 1608 (2020)
Volume 10
Issue 12
Biomolecules, Vol 10, Iss 1608, p 1608 (2020)
Kinetic studies and molecular modeling of human acetylcholinesterase (AChE) inhibition by a fluorinated acetophenone derivative, 1-(3-tert-butylphenyl)-2,2,2-trifluoroethanone (TFK), were performed. Fast reversible inhibition of AChE by TFK is of com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5653c2d3b0f1776ed349bbf3904bcd20
Autor:
D Luke, Darcy E. Burley, Ian R. Pottie, Meghan K. Cash, M W D Thorne, Sultan Darvesh, George Andrew Reid
Publikováno v:
Molecular imaging and biology. 23(1)
Molecular imaging agents targeting butyrylcholinesterase (BChE) have shown promise in other neurodegenerative disorders and may have utility in detecting changes to normal appearing white matter in multiple sclerosis (MS). BChE activity is present in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb83a7859b144e936cfd9a4fa8013cec
https://pubmed.ncbi.nlm.nih.gov/32926288
https://pubmed.ncbi.nlm.nih.gov/32926288
Autor:
Drew R. DeBay, Sultan Darvesh, Earl Martin, George Andrew Reid, Chris V. Bowen, Ian R. Pottie
Publikováno v:
Alzheimer's & Dementia : Translational Research & Clinical Interventions
Introduction Diagnosis of Alzheimer's disease (AD) in vivo, by molecular imaging of amyloid or tau, is constrained because similar changes can be found in brains of cognitively normal individuals. Butyrylcholinesterase (BChE), which becomes associate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76dce8a8ce043e1d033aac379e079243
https://doi.org/10.1016/j.trci.2017.01.005
https://doi.org/10.1016/j.trci.2017.01.005
Autor:
Earl Martin, Andrew Reid, Antoun Boulaouz, Sultan Darvesh, Chris V. Bowen, Ian R. Pottie, Drew R. DeBay, Steve Burrell
Publikováno v:
Alzheimer's & Dementia. 15:P112-P112
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25597fc19724f61d3cef8bb2c4e53b0f
https://doi.org/10.1016/j.jalz.2019.06.4250
https://doi.org/10.1016/j.jalz.2019.06.4250
Autor:
Sultan Darvesh, Earl Martin, Terrone L. Rosenberry, Ian R. Pottie, Courtney T. Jollymore-Hughes
Publikováno v:
Bioorganicmedicinal chemistry. 24(21)
Association of cholinesterase with β-amyloid plaques and tau neurofibrillary tangles in Alzheimer's disease offers an opportunity to detect disease pathology during life. Achieving this requires development of radiolabelled cholinesterase ligands wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8f33bd4547b626c65f3c79d128a21b8
https://pubmed.ncbi.nlm.nih.gov/27637382
https://pubmed.ncbi.nlm.nih.gov/27637382
Autor:
Earl Martin, Courtney T Jollymore, Ian R. Macdonald, Ian R. Pottie, G. Andrew Reid, Sultan Darvesh
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry. 28:447-455
Cholinesterases are associated with pathology characteristic of conditions such as Alzheimer's disease and are therefore, considered targets for neuroimaging. Ester derivatives of N-methylpiperidinol are promising potential imaging agents; however, m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c52dfae3ab61e30bbe62d415b6bba45
https://doi.org/10.3109/14756366.2011.647008
https://doi.org/10.3109/14756366.2011.647008