Zobrazeno 1 - 10
of 174
pro vyhledávání: '"Ian R. Lanza"'
Autor:
George R. Marcotte, Matthew J. Miller, Hawley E. Kunz, Zachary C. Ryan, Matthew D. Strub, Patrick M. Vanderboom, Carrie J. Heppelmann, Sarah Chau, Zachary D. Von Ruff, Sean P. Kilroe, Andrew T. McKeen, Jason M. Dierdorff, Jennifer I. Stern, Karl A. Nath, Chad E. Grueter, Vitor A. Lira, Andrew R. Judge, Blake B. Rasmussen, K. Sreekumaran Nair, Ian R. Lanza, Scott M. Ebert, Christopher M. Adams
Publikováno v:
JCI Insight, Vol 8, Iss 22 (2023)
Aging and many illnesses and injuries impair skeletal muscle mass and function, but the molecular mechanisms are not well understood. To better understand the mechanisms, we generated and studied transgenic mice with skeletal muscle–specific expres
Externí odkaz:
https://doaj.org/article/af1307b64c1b4419953e38f85ed47944
Autor:
Hawley E. Kunz, Ian R. Lanza
Publikováno v:
Experimental Gerontology, Vol 177, Iss , Pp 112177- (2023)
Aging is associated with profound alterations in skeletal muscle, including loss of muscle mass and function, local inflammation, altered mitochondrial physiology, and attenuated anabolic responses to exercise termed anabolic resistance. “Inflammag
Externí odkaz:
https://doaj.org/article/890e1813e00745e0a6f88143970cafc1
Autor:
Kevin J. Gries, Corey R. Hart, Hawley E. Kunz, Zachary Ryan, Xiaoyan Zhang, Mojtaba Parvizi, Yuanhang Liu, Surendra Dasari, Ian R. Lanza
Publikováno v:
Physiological Reports, Vol 10, Iss 24, Pp n/a-n/a (2022)
Abstract Obesity is associated with several skeletal muscle impairments which can be improved through an aerobic exercise prescription. The possibility that exercise responsiveness is diminished in people with obesity has been suggested but not well
Externí odkaz:
https://doaj.org/article/cf58ba3aadd64a62815d8a7bf880ed18
Publikováno v:
Journal of Clinical and Translational Science, Vol 7, Pp 94-94 (2023)
OBJECTIVES/GOALS: The study aims to identify and measure metabolites in irradiation-induced senescent pre-adipocytes induced by the increased secretion of pro-inflammatory cytokines. Through untargeted metabolomics, we seek to understand the alterati
Externí odkaz:
https://doaj.org/article/aa7ad9553608485a856ebcdda8d0e8dd
Autor:
Hawley E. Kunz, Kelly L. Michie, Kevin J. Gries, Xiaoyan Zhang, Zachary C. Ryan, Ian R. Lanza
Publikováno v:
Nutrients, Vol 14, Iss 17, p 3537 (2022)
Skeletal muscle is critical for maintaining mobility, independence, and metabolic health in older adults. However, a common feature of aging is the progressive loss of skeletal muscle mass and function, which is often accompanied by mitochondrial imp
Externí odkaz:
https://doaj.org/article/9789c1e07e904ec9bf11b0382c57b137
Autor:
Patrick M. Vanderboom, Surendra Dasari, Gregory N. Ruegsegger, Mark W. Pataky, Fabrice Lucien, Carrie Jo Heppelmann, Ian R. Lanza, K. Sreekumaran Nair
Publikováno v:
Cell Reports: Methods, Vol 1, Iss 3, Pp 100055- (2021)
Summary: Extracellular vesicles (EVs) are released into blood from multiple organs and carry molecular cargo that facilitates inter-organ communication and an integrated response to physiological and pathological stimuli. Interrogation of the protein
Externí odkaz:
https://doaj.org/article/308ab1aa0c084e0dbcffbbe5ec5c9479
Autor:
Graeme Preston, Tim Emmerzaal, Silvia Radenkovic, Ian R. Lanza, Devin Oglesbee, Eva Morava, Tamas Kozicz
Publikováno v:
Neurobiology of Stress, Vol 14, Iss , Pp 100300- (2021)
Mitochondrial metabolism is increasingly implicated in psychopathologies and mood disorders, including post-traumatic stress disorder (PTSD). We recently reported that mice exposed to a novel paradigm for the induction of PTSD-like behavior displayed
Externí odkaz:
https://doaj.org/article/99da659f62cf422487d7ac16f175c5cc
Autor:
Ha Neui Kim, Monica R. Langley, Whitney L. Simon, Hyesook Yoon, Laurel Kleppe, Ian R. Lanza, Nathan K. LeBrasseur, Aleksey Matveyenko, Isobel A. Scarisbrick
Publikováno v:
Neurobiology of Disease, Vol 141, Iss , Pp 104934- (2020)
A diet high in fat and sucrose (HFHS), the so-called Western diet promotes metabolic syndrome, a significant co-morbidity for individuals with spinal cord injury (SCI). Here we demonstrate that the spinal cord of mice consuming HFHS expresses reduced
Externí odkaz:
https://doaj.org/article/881bfc9a8a2f4d62ab095bd6e962bda3
Autor:
Adam R. Konopka, Raul Ruiz Esponda, Matthew M. Robinson, Matthew L. Johnson, Rickey E. Carter, Michele Schiavon, Claudio Cobelli, Fredric E. Wondisford, Ian R. Lanza, K. Sreekumaran Nair
Publikováno v:
Cell Reports, Vol 15, Iss 7, Pp 1394-1400 (2016)
Summary: The therapeutic mechanism of metformin action remains incompletely understood. Whether metformin inhibits glucagon-stimulated endogenous glucose production (EGP), as in preclinical studies, is unclear in humans. To test this hypothesis, we s
Externí odkaz:
https://doaj.org/article/3a0445036a964a44b608147e0fc0b1cc
Autor:
Antigoni Z. Lalia, Ian R. Lanza
Publikováno v:
Nutrients, Vol 8, Iss 6, p 329 (2016)
Omega-3 polyunsaturated fatty acids (n-3 PUFA) of marine origin, eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA), have been long studied for their therapeutic potential in the context of type 2 diabetes, insulin resistance, and glucose ho
Externí odkaz:
https://doaj.org/article/8634f263f18d4f49b5329d5643ecc74f