Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Ian R. Hazelden"'
Autor:
Benjamin R. T. Jones, Thomas Langer, Richard J. Lewis, Javier García-Cárceles, Ian R. Hazelden, Lewis Caiger, John F. Bower
Publikováno v:
Journal of the American Chemical Society
Structurally complex benzo- and spiro-fused N-polyheterocycles can be accessed via intramolecular Pd(0)-catalyzed alkene 1,2-aminoarylation reactions. The method uses N-(pentafluorobenzoyloxy)carbamates as the initiating motif, and this allows aza-He
Publikováno v:
Chemical Science
Race, N J, Hazelden, I R, Faulkner, A & Bower, J F 2017, ' Recent developments in the use of aza-Heck cyclizations for the synthesis of chiral N-heterocycles ', Chemical Science, vol. 8, no. 8, pp. 5248-5260 . https://doi.org/10.1039/c7sc01480e
Race, N J, Hazelden, I R, Faulkner, A & Bower, J F 2017, ' Recent developments in the use of aza-Heck cyclizations for the synthesis of chiral N-heterocycles ', Chemical Science, vol. 8, no. 8, pp. 5248-5260 . https://doi.org/10.1039/c7sc01480e
The scope and mechanism of aza-Heck methodologies that provide chiral heterocyclic systems are outlined.
Aza-Heck cyclizations are an emerging method for the construction of chiral N-heterocyclic systems. In these processes, an activated N–O b
Aza-Heck cyclizations are an emerging method for the construction of chiral N-heterocyclic systems. In these processes, an activated N–O b
Publikováno v:
Journal of the American Chemical Society
Ma, X, Hazelden, I, Langer, T, Munday, R & Bower, J 2019, ' Enantioselective Aza-Heck Cyclizations of N-(Tosyloxy)carbamates : Synthesis of Pyrrolidines and Piperidines ', Journal of the American Chemical Society, vol. 141, no. 8, pp. 3356-3360 . https://doi.org/10.1021/jacs.8b12689
Ma, X, Hazelden, I, Langer, T, Munday, R & Bower, J 2019, ' Enantioselective Aza-Heck Cyclizations of N-(Tosyloxy)carbamates : Synthesis of Pyrrolidines and Piperidines ', Journal of the American Chemical Society, vol. 141, no. 8, pp. 3356-3360 . https://doi.org/10.1021/jacs.8b12689
Pd(0)-systems modified with SPINOL-derived phosphoramidate ligands promote highly enantioselective aza-Heck cyclizations of alkenyl N-(tosyloxy)carbamates. The method provides versatile access to challenging N-heterocycles and representsthe broadest
DiverseN-Heterocyclic Ring Systems via Aza-Heck Cyclizations ofN-(Pentafluorobenzoyloxy)sulfonamides
Publikováno v:
Angewandte Chemie International Edition
Hazelden, I, Ma, X-F, Langer, T & Bower, J 2016, ' Diverse N-heterocyclic ring systems via aza-Heck cyclizations of N-(pentafluorobenzoyloxy)sulfonamides ', Angewandte Chemie-International Edition, vol. 55, no. 37, pp. 11198-11202 . https://doi.org/10.1002/anie.201605152
Hazelden, I, Ma, X-F, Langer, T & Bower, J 2016, ' Diverse N-heterocyclic ring systems via aza-Heck cyclizations of N-(pentafluorobenzoyloxy)sulfonamides ', Angewandte Chemie-International Edition, vol. 55, no. 37, pp. 11198-11202 . https://doi.org/10.1002/anie.201605152
Aza-Heck cyclizations initiated by oxidative addition of Pd0-catalysts into the N−O bond of N-(pentafluoro-benzoyloxy)sulfonamides are described. These studies, which encompass only the second class of aza-Heck reaction developed to date, provide d
Publikováno v:
Angewandte Chemie International Edition
Hazelden, I, Costa Carmona, R, Langer, T, Pringle, P & Bower, J 2018, ' Pyrrolidines and Piperidines by Ligand-Enabled Aza-Heck Cyclizations and Cascades of N-(Pentafluorobenzoyloxy) carbamates ', Angewandte Chemie-International Edition, vol. 57, no. 18, pp. 5124-5128 . https://doi.org/10.1002/anie.201801109
Angewandte Chemie (International Ed. in English)
Hazelden, I, Costa Carmona, R, Langer, T, Pringle, P & Bower, J 2018, ' Pyrrolidines and Piperidines by Ligand-Enabled Aza-Heck Cyclizations and Cascades of N-(Pentafluorobenzoyloxy) carbamates ', Angewandte Chemie-International Edition, vol. 57, no. 18, pp. 5124-5128 . https://doi.org/10.1002/anie.201801109
Angewandte Chemie (International Ed. in English)
Ligand‐enabled aza‐Heck cyclizations and cascades of N‐(pentafluorobenzoyloxy)carbamates are described. These studies encompass the first examples of efficient non‐biased 6‐exo aza‐Heck cyclizations. The methodology provides direct and fl