Zobrazeno 1 - 10 of 159 pro vyhledávání: '"Ian R. Booth"'
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Akademický článek
Altered antibiotic transport in OmpC mutants isolated from a series of clinical strains of multi-drug resistant E. coli.
Autor: Hubing Lou, Min Chen, Susan S Black, Simon R Bushell, Matteo Ceccarelli, Tivadar Mach, Konstantinos Beis, Alison S Low, Victoria A Bamford, Ian R Booth, Hagan Bayley, James H Naismith
Publikováno v: PLoS ONE, Vol 6, Iss 10, p e25825 (2011)
Antibiotic-resistant bacteria, particularly gram negative species, present significant health care challenges. The permeation of antibiotics through the outer membrane is largely effected by the porin superfamily, changes in which contribute to antib
Externí odkaz: https://doaj.org/article/711ecda7b47d4ed3a5c1f9ee4d31e766
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2
Towards measuring growth rates of pathogens during infections by D2O-labeling lipidomics
Autor: Dianne K. Newman, Alex L. Sessions, Cajetan Neubauer, Sebastian H. Kopf, Nathan F. Dalleska, Benjamin P. Bowen, Ian R. Booth
RATIONALEMicrobial growth rate is an important physiological parameter that is challenging to measurein situ, partly because microbes grow slowly in many environments. Recently, it has been demonstrated that generation times ofS. aureusin cystic fibr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7828f00747077cbb181f77be7a1c8559
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3
Towards measuring growth rates of pathogens during infections by D
Autor: Cajetan, Neubauer, Alex L, Sessions, Ian R, Booth, Benjamin P, Bowen, Sebastian H, Kopf, Dianne K, Newman, Nathan F, Dalleska
Publikováno v: Rapid communications in mass spectrometry : RCM. 32(24)
Microbial growth rate is an important physiological parameter that is challenging to measure in situ, partly because microbes grow slowly in many environments. Recently, it has been demonstrated that generation times of S. aureus in cystic fibrosis (
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::859238aca015c64e4d323548e7002192
https://pubmed.ncbi.nlm.nih.gov/30252972
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4
The role of lipids in mechanosensation
Autor: James H. Naismith, A. Caroline E. Dahl, Terry K. Smith, Carol V. Robinson, Thandiwe Banda, Ian R. Booth, Tim Rasmussen, Kozhinjampara R. Mahendran, Hagan Bayley, Christos Pliotas, Samantha Miller, Phedra Marius, Mark S.P. Sansom, Akiko Rasmussen, Joseph Gault
Publikováno v: Nature structural & molecular biology
This work was supported by Wellcome Trust grants WT092552MA (J.H.N. and I.R.B.), Senior Investigator Award WT100209MA (J.H.N.), 093228 (T.K.S.) and 092970 (M.S.P.S.), and Biotechnology and Biological Sciences Research Council grants BB/I019855/1 (M.S
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5abf3603b1b0bdcc2130ce5554a4cc6
https://doi.org/10.1038/nsmb.3120
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5
The evolution of bacterial mechanosensitive channels
Autor: Samantha Miller, Ian R. Booth, Laura E. Lehtovirta-Morley, Axel Müller
Publikováno v: Cell Calcium. 57:140-150
Mechanosensitive channels are ubiquitous and highly studied. However, the evolution of the bacterial channels remains enigmatic. It can be argued that mechanosensitivity might be a feature of all membrane proteins with some becoming progressively les
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::314b71edb9f9564ce7590f946a8151b7
https://doi.org/10.1016/j.ceca.2014.12.011
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7
Understanding the Structural Requirements for Activators of the Kef Bacterial Potassium Efflux System
Autor: Tim Rasmussen, Silvia Ekkerman, Garrett M. Morris, Samantha Miller, Samuel C. Grayer, Morgiane Richard, Wendy Bartlett, Jessica Healy, Stuart J. Conway, Christos Pliotas, Ian R. Booth
Publikováno v: Healy, J, Ekkerman, S, Pliotas, C, Richard, M, Bartlett, W, Grayer, S C, Morris, G M, Miller, S, Booth, I R, Conway, S J & Rasmussen, T 2014, ' Understanding the structural requirements for activators of the Kef bacterial potassium efflux system ', Biochemistry, vol. 53, no. 12, pp. 1982–1992 . https://doi.org/10.1021/bi5001118
Biochemistry
This work was supported by The Wellcome Trust (WT092552MA), The Leverhulme Trust (EM-2012-60\2), BBSRC SysMO (BB/F003455/1), a European Union Marie Curie ITN Award (NICHE; 289384) The potassium efflux system, Kef, protects bacteria against the detrim
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d83aa80a6b147f6db171edb1ee37e710
https://doi.org/10.1021/bi5001118
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8
Probing the Structure of the Mechanosensitive Channel of Small Conductance in Lipid Bilayers with Pulsed Electron-Electron Double Resonance
Autor: John M. Lucocq, James H. Naismith, Christian Hacker, Olav Schiemann, Gregor Hagelueken, Christos Pliotas, Ian R. Booth, Emma Branigan, Akiko Rasmussen, Richard J. Ward, Samantha Miller
Publikováno v: Ward, R, Pliotas, C, Branigan, E, Hacker, C, Rasmussen, A, Hagelueken, G, Booth, I R, Miller, S, Lucocq, J, Naismith, J H & Schiemann, O 2014, ' Probing the structure of the mechanosensitive channel of small conductance in lipid bilayers with pulsed electron-electron double resonance ', Biophysical Journal, vol. 106, no. 4, pp. 834-842 . https://doi.org/10.1016/j.bpj.2014.01.008
Funding: EaStCHEM studentship to E.B. The work was funded by BBSRC grant BB/H017917/1 to JNH, OS & IRB, The Leverhulme Foundation (EM-2012-60\2) and equipment from a Wellcome Trust Capital Award. Mechanosensitive channel proteins are important safety
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d74fc111fb39fdca5e201c9ae8cbcf2
https://doi.org/10.1016/j.bpj.2014.01.008
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9
Integrated stress response of E scherichia coli to methylglyoxal: transcriptional readthrough from the nemRA operon enhances protection through increased expression of glyoxalase I
Autor: Alessandro P. S. de Moura, Ertan Ozyamak, Samantha Miller, Camila de Almeida, Ian R. Booth
Publikováno v: Molecular Microbiology. 88:936-950
Methylglyoxal (MG) elicits activation of K+ efflux systems to protect cells against the toxicity of the electrophile. ChIP-chip targeting RNA polymerase, supported by a range of other biochemical measurements and mutant creation, was used to identify
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9260eee0c6a3d60a661bceff1d011c28
https://doi.org/10.1111/mmi.12234
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10
Altered antibiotic transport in OmpC mutants isolated from a series of clinical strains of multi-drug resistant E. coli
Autor: Hagan Bayley, Alison S. Low, Hubing Lou, Tivadar Mach, Konstantinos Beis, Susan Shirley Black, James H. Naismith, S.R. Bushell, Vicki A. Bamford, Matteo Ceccarelli, Ian R. Booth, Min Chen
Publikováno v: PloS one 6 (2011): e25825. doi:10.1371/journal.pone.0025825
info:cnr-pdr/source/autori:Hubing Lou, Min Chen, Susan S Black, Simon R Bushell, Matteo Ceccarelli, Tivadar Mach, Konstantinos Beis, Alison S Low, Victoria A Bamford, Ian R Booth, Hagan Bayley, and James H Naismith/titolo:Altered antibiotic transport in OmpC mutants isolated from a series of clinical strains of multi-drug resistant E.coli/doi:10.1371%2Fjournal.pone.0025825/rivista:PloS one/anno:2011/pagina_da:e25825/pagina_a:/intervallo_pagine:e25825/volume:6
PLoS ONE
PLoS ONE, Vol 6, Iss 10, p e25825 (2011)
This work is also partially supported by BBSRC and the Scottish Funding Council (through SULSA) Antibiotic-resistant bacteria, particularly Gram negative species, present significant health care challenges. The permeation of antibiotics through the o
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d00689d8c4462a9d152bd91798bc2007
https://ora.ox.ac.uk/objects/uuid:11b7908d-63ca-4f4b-a66b-72ad33a2a048
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