Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Ian R Rosewell"'
Publikováno v:
Immunity. 7(5):591-599
A major issue is whether surface expression of the pre-TCR is necessary for signaling the development of immature thymocytes. To address this question, we generated transgenic mice expressing a TCRbeta chain that had a strong endoplasmic reticulum (E
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2833e129d2dad4ba0cdb4fbb62e6ee20
Autor:
Kimberly C Gilmour, Tessa Crompton, Angela Denzel, Bjorn R. Olsen, Ian R Rosewell, Gordon Stamp, Stefan Mundlos, Rosa S.P Beddington, Florian Otto, Paul B. Selby, Michael John Owen, Anders P Thornell
Publikováno v:
Cell. 89:765-771
We have generated Cbfa1-deficient mice. Homozygous mutants die of respiratory failure shortly after birth. Analysis of their skeletons revealed an absence of osteoblasts and bone. Heterozygous mice showed specific skeletal abnormalities that are char
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fba3b808d9ff98c20430383dc34e39cf
https://doi.org/10.1016/s0092-8674(00)80259-7
https://doi.org/10.1016/s0092-8674(00)80259-7
Autor:
Ian R, Rosewell, Adam, Giangreco
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 916
Local tissue stem cells are known to exist in mammalian lungs but their role in epithelial maintenance remains unclear. We therefore developed murine aggregation chimera and wholemount imaging techniques to assess the contribution of these cells to l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6312cbedec452deae0523c332b79f541
https://pubmed.ncbi.nlm.nih.gov/22914947
https://pubmed.ncbi.nlm.nih.gov/22914947
Autor:
Ian R. Rosewell, Adam Giangreco
Publikováno v:
Methods in Molecular Biology ISBN: 9781617799792
Local tissue stem cells are known to exist in mammalian lungs but their role in epithelial maintenance remains unclear. We therefore developed murine aggregation chimera and wholemount imaging techniques to assess the contribution of these cells to l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5401fb4a2a3da7c374e859757ad759b7
https://doi.org/10.1007/978-1-61779-980-8_20
https://doi.org/10.1007/978-1-61779-980-8_20
Publikováno v:
Nucleic Acids Research. 20:2693-2698
In order to facilitate alterations of large DNA molecules for their introduction into mammalian cells we have characterised the mechanism of site-specific modifications in yeast artificial chromosomes (YACs). Newly developed yeast integration vectors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::718c376436cbc65ffc01a4a29cad91fb
https://doi.org/10.1093/nar/20.11.2693
https://doi.org/10.1093/nar/20.11.2693
Autor:
David Jackson, Paul A.W. Edwards, Vera Fantl, Christian Dillon, Ian R Rosewell, Anna Creer, Clive Dickson, Janine Bresnick
Publikováno v:
Biology of the Mammary Gland ISBN: 0306464144
A number of growth factors, growth factor receptors and cell cycle regulatory proteins have been implicated in the genesis of mammary carcinomas both in animal models as well as in human breast tumour samples. Studies on the development of the mammar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7cc74328df9f246322d52ca5fe6f0f55
https://doi.org/10.1007/0-306-46832-8_1
https://doi.org/10.1007/0-306-46832-8_1
Autor:
Paul Ayton, R. Presley, Sharon Sneddon, Michael John Owen, Donald B. Palmer, Ian R Rosewell, Vasanta Subramanian, Bryan D. Young
Publikováno v:
Genesis (New York, N.Y. : 2000). 30(4)
The mixed lineage leukemia gene (MLL) was originally identified through its involvement in reciprocal translocations in leukemias. MLL codes for a large multidomain protein and bears homology to the Drosophila developmental control gene trithorax in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::657a72873860e85774e1e88ea03cddcd
https://pubmed.ncbi.nlm.nih.gov/11536426
https://pubmed.ncbi.nlm.nih.gov/11536426
Autor:
R.C.E. Solarie, Rainer Pepperkok, Florian Otto, Ian R Rosewell, R. Watson, Angela Denzel, Michael John Owen, A. Girod, J.J.M. Bergeron
Publikováno v:
Current biology : CB. 10(1)
The p24 family of type I integral-membrane proteins, which are localised in the endoplasmic reticulum (ER) [1–3], the intermediate compartment and the Golgi apparatus, are thought to function as receptors for cargo exit from the ER and in transport
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0713fb856c62695ab8b675307ace6ab3
https://pubmed.ncbi.nlm.nih.gov/10660306
https://pubmed.ncbi.nlm.nih.gov/10660306
Autor:
M Hajihosseini, Ian R Rosewell, Clive Dickson, Jean-Michel Revest, L De Moerlooze, Bradley Spencer-Dene
Publikováno v:
Development (Cambridge, England)
Development (Cambridge, England), Company of Biologists, 2000, 127 (3), pp.483-92
Development (Cambridge, England), Company of Biologists, 2000, 127 (3), pp.483-92
The fibroblast growth factor receptor 2 gene is differentially spliced to encode two transmembrane tyrosine kinase receptor proteins that have different ligandbinding specificities and exclusive tissue distributions. We have used Cre-mediated excisio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::861456a0258b35dcfcaa6e54e74e2e91
https://hal.archives-ouvertes.fr/hal-02325983
https://hal.archives-ouvertes.fr/hal-02325983
Autor:
Graham P. Cook, Ian R. Rosewell, Nicholas P. Davies, Michael S. Neuberger, Jenny C. Richardson, M. L. Norris, Marianne Brüggemann, Bernard H. Brownstein
Publikováno v:
Bio/technology (Nature Publishing Company). 11(8)
We have previously described a strategy for integrating selectable marker genes into yeast artificial chromosomes (YACs) to facilitate their transfer into embryonic stem (ES) cells. Here we apply this technology to create mice carrying the core regio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3594dcc2079a4e22ce827618908c8173
https://pubmed.ncbi.nlm.nih.gov/7763914
https://pubmed.ncbi.nlm.nih.gov/7763914