Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Ian R McCracken"'
Autor:
Ana-Mishel Spiroski, Ian R. McCracken, Adrian Thomson, Marlene Magalhaes-Pinto, Mukesh K. Lalwani, Kathryn J. Newton, Eileen Miller, Cecile Bénézech, Patrick Hadoke, Mairi Brittan, Joanne C. Mountford, Abdelaziz Beqqali, Gillian A. Gray, Andrew H. Baker
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
BackgroundMechanisms contributing to tissue remodeling of the infarcted heart following cell-based therapy remain elusive. While cell-based interventions have the potential to influence the cardiac healing process, there is little direct evidence of
Externí odkaz:
https://doaj.org/article/7124b2c9b1f04665b50be22f557a3574
Autor:
Ana-Mishel Spiroski, Rachel Sanders, Marco Meloni, Ian R. McCracken, Adrian Thomson, Mairi Brittan, Gillian A. Gray, Andrew H. Baker
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 2, p 969 (2021)
Long non-coding RNAs (lncRNAs) have structural and functional roles in development and disease. We have previously shown that the LINC00961/SPAAR (small regulatory polypeptide of amino acid response) locus regulates endothelial cell function, and tha
Externí odkaz:
https://doaj.org/article/bbe28b60ae8b4bfa899094a73d4358e8
Autor:
Kim van Kuijk, Ian R McCracken, Renée J H A Tillie, Sebastiaan E J Asselberghs, Dlzar A Kheder, Stan Muitjens, Han Jin, Richard S Taylor, Ruud Wichers Schreur, Christoph Kuppe, Ross Dobie, Prakesh Ramachandran, Marion J Gijbels, Lieve Temmerman, Phoebe M Kirkwoord, Joris Luyten, Yanming Li, Heidi Noels, Pieter Goossens, John R Wilson-Kanamori, Leon J Schurgers, Ying H Shen, Barend M E Mees, Erik A L Biessen, Neil C Henderson, Rafael Kramann, Andrew H Baker, Judith C Sluimer
Publikováno v:
van Kuijk, K, McCracken, I, Tillie, RJHA, Asselberghs, SEJ, Kheder, DA, Muitjens, S, Jin, H, Taylor, R S, Wichers Schreur, R, Kuppe, C, Dobie, R, Ramachandran, P, Gijbels, M J, Temmerman, L, Kirkwoord, PM, Luyten, J, Li, Y, Noels, H, Goossens, P, Wilson-Kanamori, J R, Schurgers, L J, Shen, YH, Mees, BME, Biessen, E A L, Henderson, N C, Kramann, R, Baker, A H & Sluimer, J 2023, ' Human and murine fibroblast single cell transcriptomics reveals fibroblast clusters are differentially affected by ageing, and serum cholesterol ', Cardiovascular Research . https://doi.org/10.1093/cvr/cvad016
Aims Specific fibroblast markers and in-depth heterogeneity analysis are currently lacking, hindering functional studies in cardiovascular diseases (CVDs). Here, we established cell-type markers and heterogeneity in murine and human arteries and stud
Autor:
Ziwen Li, Emmanouil G Solomonidis, Bronwyn Berkeley, Michelle Nga Huen Tang, Katherine Ross Stewart, Daniel Perez-Vicencio, Ian R McCracken, Ana-Mishel Spiroski, Gillian A Gray, Anna K Barton, Stephanie L Sellers, Paul R Riley, Andrew H Baker, Mairi Brittan
Publikováno v:
Young investigators award.
Autor:
Richard S Taylor, Ian R McCracken, Ross Dobie, Axelle Caudrillier, Fernando de la Cuesta, Andrew H. Baker, Fatma Olcay Kok, Neil C. Henderson, Joanne C. Mountford, Beth E. P. Henderson, Chris P. Ponting
Publikováno v:
McCracken, I R, Taylor, R S, Kok, F O, de la Cuesta, F, Dobie, R, Henderson, B E P, Mountford, J C, Caudrillier, A, Henderson, N C, Ponting, C P & Baker, A H 2020, ' Transcriptional dynamics of pluripotent stem cell-derived endothelial cell differentiation revealed by single-cell RNA sequencing ', European Heart Journal, vol. 41, no. 9, pp. 1024–1036 . https://doi.org/10.1093/eurheartj/ehz351
Biblos-e Archivo. Repositorio Institucional de la UAM
instname
Biblos-e Archivo: Repositorio Institucional de la UAM
Universidad Autónoma de Madrid
Biblos-e Archivo. Repositorio Institucional de la UAM
instname
Biblos-e Archivo: Repositorio Institucional de la UAM
Universidad Autónoma de Madrid
Aims Pluripotent stem cell-derived endothelial cell products possess therapeutic potential in ischaemic vascular disease. However, the factors that drive endothelial differentiation from pluripotency and cellular specification are largely unknown. Th
Autor:
Lars Muhl, Viktoria Kalna, Christine Tait-Burkard, Christer Betsholtz, Urban Lendahl, Samantha J. Griffiths, Liqun He, Maarja Andaloussi-Mäe, Jürgen Haas, Nicky M. Craig, Michela Noseda, Andrew H. Baker, Graeme M. Birdsey, Anna M. Randi, Alik Huseynov, Ian R McCracken, Claire Peghaire, Sarah Fletcher, Alison Daniels, Gaye Saginc
Publikováno v:
Mccracken, I R, Saginc, G, He, L, Huseynov, A, Daniels, A, Fletcher, S, Peghaire, C, Kalna, V, Andaloussi-mäe, M, Muhl, L, Craig, N M, Griffiths, S J, Haas, J G, Tait-burkard, C, Lendahl, U, Birdsey, G M, Betsholtz, C, Noseda, M, Baker, A H & Randi, A M 2021, ' Lack of Evidence of ACE2 Expression and Replicative Infection by SARSCoV-2 in Human Endothelial Cells ', Circulation . https://doi.org/10.1161/CIRCULATIONAHA.120.052824
McCracken, I, Saginc, G, He, L, Huseynov, A, Daniels, A, Fletcher, S, Peghaire, C, Kalna, V, Andaloussi-mäe, M, Muhl, L, Craig, N, Griffiths, S, Haas, J G, Tait-Burkard, C, Lendahl, U, Birdsey, G M, Betsholtz, C, Noseda, M, Baker, A H & Randi, AM 2021, ' Lack of evidence of ACE2 expression and replicative infection by SARS-CoV-2 in human endothelial cells ', Circulation, vol. 143, no. 8, pp. 865–868 . https://doi.org/10.1101/2020.12.02.391664, https://doi.org/10.1161/CIRCULATIONAHA.120.052824
McCracken, I, Saginc, G, He, L, Huseynov, A, Daniels, A, Fletcher, S, Peghaire, C, Kalna, V, Andaloussi-mäe, M, Muhl, L, Craig, N, Griffiths, S, Haas, J G, Tait-Burkard, C, Lendahl, U, Birdsey, G M, Betsholtz, C, Noseda, M, Baker, A H & Randi, AM 2021, ' Lack of evidence of ACE2 expression and replicative infection by SARS-CoV-2 in human endothelial cells ', Circulation, vol. 143, no. 8, pp. 865–868 . https://doi.org/10.1101/2020.12.02.391664, https://doi.org/10.1161/CIRCULATIONAHA.120.052824
A striking feature of severe COVID-19 is thrombosis in large as well as small vessels of multiple organs. This has led to the assumption that SARS-CoV-2 virus directly infects and damages the vascular endothelium. However, endothelial expression of A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24aa94feee0c5342e43995e3943c7a0e
https://hdl.handle.net/20.500.11820/3bc7226a-64ab-47ee-a209-60b325542bf6
https://hdl.handle.net/20.500.11820/3bc7226a-64ab-47ee-a209-60b325542bf6
Autor:
Sarah Fletcher, Michela Noseda, Gaye Saginc, Christine Tait-Burkard, Claire Peghaire, Maarja Andaloussi-Mäe, Ian R McCracken, Alik Huseynov, Graeme M. Birdsey, Urban Lendahl, Alison Daniels, Andy Baker, Liqun He, Samantha J. Griffiths, Jürgen Haas, Nicky M. Craig, Anna M. Randi, Christer Betsholtz, Viktoria Kalna, Lars Muhl
Publikováno v:
Circulation
Autor:
Maarten Vanhaverbeke, Costanza Emanueli, Stephane Heymans, Carlo Gaetano, Thomas Thum, K P Srivastava, Ian R McCracken, EU-CardioRNA Cost Action Ca, Emma L. Robinson, Gianluigi Condorelli, Andrew H. Baker, Fabio Martelli, Mairi Brittan, Thierry Pedrazzini, Claudio Angione, Yvan Devaux
Publikováno v:
Robinson, E, Baker, A H, Brittan, M, McCracken, I, Condorelli, G, Emanueli, C, Srivastava, KP, Gaetano, C, Thum, T, Vanhaverbeke, M, Angione, C, Heymans, S, Devaux, Y, Pedrazzini, T & Martelli, F 2021, ' Dissecting the transcriptome in cardiovascular disease ', Cardiovascular Research . https://doi.org/10.1093/cvr/cvab117
The human transcriptome comprises a complex network of coding and non-coding RNAs implicated in a myriad of biological functions. Non-coding RNAs exhibit highly organized spatial and temporal expression patterns and are emerging as critical regulator
Autor:
Chris P. Ponting, Ian R McCracken, Beth E. P. Henderson, Andy Baker, Ross Dobie, Neil C. Henderson, Axelle Caudrillier, Richard S Taylor, Joanne C Mountford, Fernando de la Cuesta
Publikováno v:
Circulation Research. 125
Objectives: Human embryonic stem cell derived endothelial cell (hESC-EC) differentiation offers a model to study the process of endothelial development, commitment and maturation, thus potentially informing future regeneration strategies. We used hig
Publikováno v:
Current Opinion in Lipidology, 29(6), 488-489. LIPPINCOTT WILLIAMS & WILKINS
McCracken, I, Taylor, R, Henderson, N, Sluimer, J & Baker, A 2018, ' Unravelling atherosclerotic heterogeneity by single cell RNA sequencing ', Current Opinion in Lipidology . https://doi.org/10.1097/MOL.0000000000000559
McCracken, I, Taylor, R, Henderson, N, Sluimer, J & Baker, A 2018, ' Unravelling atherosclerotic heterogeneity by single cell RNA sequencing ', Current Opinion in Lipidology . https://doi.org/10.1097/MOL.0000000000000559