Zobrazeno 1 - 10
of 110
pro vyhledávání: '"Ian R, Monk"'
Autor:
Heran Zhang, Ian R. Monk, Jessica Braverman, Claerwen M. Jones, Andrew G. Brooks, Timothy P. Stinear, Linda M. Wakim
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Superantigens (sAgs) are bacterial virulence factors that induce a state of immune hyperactivation by forming a bridge between certain subsets of T cell receptor (TCR) β chains on T lymphocytes, and class II major histocompatibility complex
Externí odkaz:
https://doaj.org/article/c05a1fab140c4c649629a5df6a0761ef
Autor:
Jacob Fry, Jean Y. H. Lee, Julie L. McAuley, Jessica L. Porter, Ian R. Monk, Samuel T. Martin, David J. Collins, Gregory J. Barbante, Nicholas J. Fitzgerald, Timothy P. Stinear
Publikováno v:
ACS Omega, Vol 9, Iss 39, Pp 40832-40840 (2024)
Externí odkaz:
https://doaj.org/article/d450b3169bef4deb8b65be3fa933a452
Autor:
Yi Nong, Eike Steinig, Georgina L. Pollock, George Taiaroa, Glen P. Carter, Ian R. Monk, Stanley Pang, Denise A. Daley, Geoffrey W. Coombs, Brian M. Forde, Patrick N. A. Harris, Norelle L. Sherry, Benjamin P. Howden, Shivani Pasricha, Sarah L. Baines, Deborah A. Williamson
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-10 (2024)
Abstract The past decade has seen an increase in the prevalence of sequence type (ST) 45 methicillin-resistant Staphylococcus aureus (MRSA), yet the underlying drivers for its emergence and spread remain unclear. To better understand the worldwide di
Externí odkaz:
https://doaj.org/article/d738cf3544a04aedbcf99c1a4ea67914
Autor:
Sacha J Pidot, Stephan Klatt, Louis S Ates, Wafa Frigui, Fadel Sayes, Laleh Majlessi, Hiroshi Izumi, Ian R Monk, Jessica L Porter, Vicki Bennett-Wood, Torsten Seemann, Ashley Otter, George Taiaroa, Gregory M Cook, Nicholas West, Nicholas J Tobias, John A Fuerst, Michael D Stutz, Marc Pellegrini, Malcolm McConville, Roland Brosch, Timothy P Stinear
Publikováno v:
PLoS Pathogens, Vol 20, Iss 8, p e1012440 (2024)
Reconstructing the evolutionary origins of Mycobacterium tuberculosis, the causative agent of human tuberculosis, has helped identify bacterial factors that have led to the tubercle bacillus becoming such a formidable human pathogen. Here we report t
Externí odkaz:
https://doaj.org/article/c05a679dcd724c87b14f99cec3647995
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Staphylococcus aureus bacteremia causes significant morbidity and mortality. Treatment of staphylococcal infections is hindered by widespread antibiotic resistance, and attempts to develop an S. aureus vaccine have failed. Improved S. aureus treatmen
Externí odkaz:
https://doaj.org/article/b4feca047c2643668ace208eafdda409
Autor:
Liam K. R. Sharkey, Romain Guerillot, Calum J. Walsh, Adrianna M. Turner, Jean Y. H. Lee, Stephanie L. Neville, Stephan Klatt, Sarah L. Baines, Sacha J. Pidot, Fernando J. Rossello, Torsten Seemann, Hamish E. G. McWilliam, Ellie Cho, Glen P. Carter, Benjamin P. Howden, Christopher A. McDevitt, Abderrahman Hachani, Timothy P. Stinear, Ian R. Monk
Publikováno v:
mBio, Vol 14, Iss 6 (2023)
ABSTRACTAmong the 16 two-component systems in the opportunistic human pathogen Staphylococcus aureus, only WalKR is essential. Like the orthologous systems in other Bacillota, S. aureus WalKR controls autolysins involved in peptidoglycan remodeling a
Externí odkaz:
https://doaj.org/article/b925679724c74489887fb31d58cddb66
Autor:
Daniel G. Mediati, Julia L. Wong, Wei Gao, Stuart McKellar, Chi Nam Ignatius Pang, Sylvania Wu, Winton Wu, Brandon Sy, Ian R. Monk, Joanna M. Biazik, Marc R. Wilkins, Benjamin P. Howden, Timothy P. Stinear, Sander Granneman, Jai J. Tree
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Regulatory small RNA (sRNA) interact with mRNAs to regulate their stability, transcription, and translation via diverse mechanisms. Here, Mediati et al. apply RNase III-CLASH to multidrug-resistant Staphylococcus aureus to characterise the network of
Externí odkaz:
https://doaj.org/article/d679ff7794784a6c999945fa7bd9395e
Staphylococcus aureus stimulates neutrophil itaconate production that suppresses the oxidative burst
Autor:
Kira L. Tomlinson, Sebastián A. Riquelme, Swikrity Upadhyay Baskota, Marija Drikic, Ian R. Monk, Timothy P. Stinear, Ian A. Lewis, Alice S. Prince
Publikováno v:
Cell Reports, Vol 42, Iss 2, Pp 112064- (2023)
Summary: Neutrophils are critical in the host defense against Staphylococcus aureus, a major human pathogen. However, even in the setting of a robust neutrophil response, S. aureus can evade immune clearance. Here, we demonstrate that S. aureus impai
Externí odkaz:
https://doaj.org/article/767b8e41e2d14568853587d3c6c14abe
Autor:
Daniel G. Mediati, Julia L. Wong, Wei Gao, Stuart McKellar, Chi Nam Ignatius Pang, Sylvania Wu, Winton Wu, Brandon Sy, Ian R. Monk, Joanna M. Biazik, Marc R. Wilkins, Benjamin P. Howden, Timothy P. Stinear, Sander Granneman, Jai J. Tree
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/54fa913078284d69af4dba8037a9a965
Autor:
Ian R. Monk, Nausad Shaikh, Stephanie L. Begg, Mike Gajdiss, Liam K. R. Sharkey, Jean Y. H. Lee, Sacha J. Pidot, Torsten Seemann, Michael Kuiper, Brit Winnen, Rikki Hvorup, Brett M. Collins, Gabriele Bierbaum, Saumya R. Udagedara, Jacqueline R. Morey, Neha Pulyani, Benjamin P. Howden, Megan J. Maher, Christopher A. McDevitt, Glenn F. King, Timothy P. Stinear
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
WalKR is an essential two-component regulator that controls peptidoglycan synthesis in the human pathogen Staphylococcus aureus. Here, the authors provide biochemical, structural, and functional evidence supporting that the binding of a zinc ion inhi
Externí odkaz:
https://doaj.org/article/8c79c77e7e1c43c2b593eb5939e70c11