Zobrazeno 1 - 10
of 89
pro vyhledávání: '"Ian R, Adams"'
Autor:
Adam E. Hall, Sebastian Öther-Gee Pohl, Patrizia Cammareri, Stuart Aitken, Nicholas T. Younger, Michela Raponi, Caroline V. Billard, Alfonso Bolado Carrancio, Aslihan Bastem, Paz Freile, Fiona Haward, Ian R. Adams, Javier F. Caceres, Paula Preyzner, Alex von Kriegsheim, Malcolm G. Dunlop, Farhat V. Din, Kevin B. Myant
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
The influence of mRNA splicing on colon cancer development and progression is unclear. In this study, the authors demonstrate that the SRSF1 splicing factor is essential to sustain the stem cell phenotype of WNT-activated colorectal cancers.
Externí odkaz:
https://doaj.org/article/b084ea4f47254a91b5543e19fe89996c
Nucleo-cytoplasmic shuttling of splicing factor SRSF1 is required for development and cilia function
Autor:
Fiona Haward, Magdalena M Maslon, Patricia L Yeyati, Nicolas Bellora, Jan N Hansen, Stuart Aitken, Jennifer Lawson, Alex von Kriegsheim, Dagmar Wachten, Pleasantine Mill, Ian R Adams, Javier F Caceres
Publikováno v:
eLife, Vol 10 (2021)
Shuttling RNA-binding proteins coordinate nuclear and cytoplasmic steps of gene expression. The SR family proteins regulate RNA splicing in the nucleus and a subset of them, including SRSF1, shuttles between the nucleus and cytoplasm affecting post-s
Externí odkaz:
https://doaj.org/article/845f0738991141b2b17f24634db90462
Autor:
Martin A M Reijns, Louise Thompson, Juan Carlos Acosta, Holly A Black, Francisco J Sanchez-Luque, Austin Diamond, David A Parry, Alison Daniels, Marie O'Shea, Carolina Uggenti, Maria C Sanchez, Alan O'Callaghan, Michelle L L McNab, Martyna Adamowicz, Elias T Friman, Toby Hurd, Edward J Jarman, Frederic Li Mow Chee, Jacqueline K Rainger, Marion Walker, Camilla Drake, Dasa Longman, Christine Mordstein, Sophie J Warlow, Stewart McKay, Louise Slater, Morad Ansari, Ian P M Tomlinson, David Moore, Nadine Wilkinson, Jill Shepherd, Kate Templeton, Ingolfur Johannessen, Christine Tait-Burkard, Jürgen G Haas, Nick Gilbert, Ian R Adams, Andrew P Jackson
Publikováno v:
PLoS Biology, Vol 18, Iss 12, p e3001030 (2020)
With the ongoing COVID-19 (Coronavirus Disease 2019) pandemic, caused by the novel coronavirus SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2), there is a need for sensitive, specific, and affordable diagnostic tests to identify infected
Externí odkaz:
https://doaj.org/article/cd5310c0965d4b4f882567dc2bff3e3b
Autor:
James H. Crichton, James M. Dunce, Orla M. Dunne, Lucy J. Salmon, Paul S. Devenney, Jennifer Lawson, Ian R. Adams, Owen R. Davies
Publikováno v:
Crichton, J, Dunce, J M, Dunne, O M, Salmon, L, Devenney, P S, Lawson, J, Adams, I R & Davies, O 2023, ' Structural maturation of SYCP1-mediated meiotic chromosome synapsis by SYCE3 ', Nature Structural & Molecular Biology . https://doi.org/10.1038/s41594-022-00909-1
In meiosis, a supramolecular protein structure, the synaptonemal complex (SC), assembles between homologous chromosomes to facilitate their recombination. Mammalian SC formation is thought to involve hierarchical zipper-like assembly of an SYCP1 prot
Autor:
Katy McLaughlin, Ilya M. Flyamer, John P. Thomson, Heidi K. Mjoseng, Ruchi Shukla, Iain Williamson, Graeme R. Grimes, Robert S. Illingworth, Ian R. Adams, Sari Pennings, Richard R. Meehan, Wendy A. Bickmore
Publikováno v:
Cell Reports, Vol 29, Iss 7, Pp 1974-1985.e6 (2019)
Summary: The DNA hypomethylation that occurs when embryonic stem cells (ESCs) are directed to the ground state of naive pluripotency by culturing in two small molecule inhibitors (2i) results in redistribution of polycomb (H3K27me3) away from its tar
Externí odkaz:
https://doaj.org/article/494966c0bb4449d6817be1b988d20ad1
Autor:
Ian R. Adams, Owen R. Davies
Publikováno v:
Annual Review of Genomics and Human Genetics. 24
In meiosis, homologous chromosome synapsis is mediated by a supramolecular protein structure, the synaptonemal complex (SC), that assembles between homologous chromosome axes. The mammalian SC comprises at least eight largely coiled-coil proteins tha
Autor:
Ingrid Ehrmann, James H Crichton, Matthew R Gazzara, Katherine James, Yilei Liu, Sushma Nagaraja Grellscheid, Tomaž Curk, Dirk de Rooij, Jannetta S Steyn, Simon Cockell, Ian R Adams, Yoseph Barash, David J Elliott
Publikováno v:
eLife, Vol 8 (2019)
Male germ cells of all placental mammals express an ancient nuclear RNA binding protein of unknown function called RBMXL2. Here we find that deletion of the retrogene encoding RBMXL2 blocks spermatogenesis. Transcriptome analyses of age-matched delet
Externí odkaz:
https://doaj.org/article/12240c42201f4f579a3d5b6ca4c05d50
Autor:
Brianda A. Hernandez-Moran, Andrew S. Papanastasiou, David Parry, Alison Meynert, Philippe Gautier, Graeme Grimes, Ian R. Adams, Violeta Trejo-Reveles, Hemant Bengani, Margaret Keighren, Ian J. Jackson, David J. Adams, David R. FitzPatrick, Joe Rainger
Publikováno v:
Genes; Volume 13; Issue 10; Pages: 1797
Hernandez-Moran, B A, Papanastasiou, A, Parry, D, Meynert, A M, Gautier, P, Grimes, G R, Adams, I R, Trejo-Reveles, V, Bengani, H, Keighren, M, Jackson, I J, Adams, D J, FitzPatrick, D R & Rainger, J 2022, ' Robust genetic analysis of the X-linked anophthalmic (Ie) mouse ', Genes, vol. 13, no. 10, 1797, pp. 1-14 . https://doi.org/10.3390/genes13101797
Hernandez-Moran, B A, Papanastasiou, A, Parry, D, Meynert, A M, Gautier, P, Grimes, G R, Adams, I R, Trejo-Reveles, V, Bengani, H, Keighren, M, Jackson, I J, Adams, D J, FitzPatrick, D R & Rainger, J 2022, ' Robust genetic analysis of the X-linked anophthalmic (Ie) mouse ', Genes, vol. 13, no. 10, 1797, pp. 1-14 . https://doi.org/10.3390/genes13101797
Anophthalmia (missing eye) describes a failure of early embryonic ocular development. Mutations in a relatively small set of genes account for 75% of bilateral anophthalmia cases, yet 25% of families currently are left without a molecular diagnosis.
Autor:
Kirsty McLennan, Ellen Barton, Christie Lang, Ian R. Adams, Gina McAllister, Martin A.M. Reijns, Kate Templeton, Ingólfur Johannessen, Alastair Leckie, Nick Gilbert
Publikováno v:
McLennan, K, Lang, C, Adams, I R, McAllister, G, Reijns, M A M, Templeton, K, Johannessen, I, Leckie, A & Gilbert, N 2022, ' User acceptability of saliva and gargle samples for identifying COVID-19 positive high-risk workers and household contacts ', Diagnostic microbiology and infectious disease, vol. 104, no. 1, 115732 . https://doi.org/10.1016/j.diagmicrobio.2022.115732
Throughout the COVID-19 pandemic nasopharyngeal or nose and/or throat swabs (NTS) have been the primary approach for collecting patient samples for the subsequent detection of viral RNA. However, this procedure, if undertaken correctly, can be unplea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85fdaef921c3a350d82233046a29d7ff
https://hdl.handle.net/20.500.11820/4ef84a53-162b-464b-a230-cca52e602e54
https://hdl.handle.net/20.500.11820/4ef84a53-162b-464b-a230-cca52e602e54
Autor:
Brianda Areli Hernandez-Moran, Andrew S Papanastasiou, Dave Parry, Alison Meynert, Phillipe Gautier, Graeme Grimes, Ian R Adams, Violeta Trejo-Reveles, Hemant Bengani, Margaret Keighren, Ian J Jackson, David J Adams, David R FitzPatrick, Joe Rainger
Anophthalmia (missing eye) describes a failure of early embryonic ocular development. Mutations in a relatively small set of genes account for 75% of bilateral anophthalmia cases, yet 25% of families currently are left without a molecular diagnosis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eec85128c105efbfd42e7a59d1d344ee
https://doi.org/10.1101/2022.08.05.502661
https://doi.org/10.1101/2022.08.05.502661