Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Ian Prosser"'
Autor:
Kenneth F. Bradstock, Alec Morley, Karen Byth, Jeff Szer, Ian Prosser, Paul Cannell, Ian Irving, John F. Seymour
Publikováno v:
Contemporary Clinical Trials Communications, Vol 4, Iss C, Pp 9-13 (2016)
An intensive induction regimen, consisting of idarubicin and high dose cytarabine, was assessed in 19 adult patients, median age 44 years, with newly diagnosed precursor-B acute lymphoblastic leukemia (ALL). Patients achieving a complete response (CR
Externí odkaz:
https://doaj.org/article/109c03693b674aa18a3988208ecf64af
Autor:
Paula Marlton, Greg Hapgood, John F. Seymour, Ian Prosser, Janey M. Stone, Diana Zannino, Chi-Hung Hui, Anup George, Ian D. Lewis, Henry Miles Prince, Kenneth F. Bradstock
Publikováno v:
Leukemialymphoma. 60(4)
To improve complete remission (CR) rates by reducing toxicity and enhancing delivery, we created a modified hyper-CVAD/MA regimen (cyclophosphamide, vincristine, doxorubicin, dexamethasone/methotrexate, cytarabine) by reducing the cytarabine dose (3
Autor:
Nigel Patton, Ian Prosser, Shir-Jing Ho, Tony Mills, John F. Seymour, Emma Link, Andrew Nicol, Diana Zannino, Mark Hertzberg, Melita Kenealy, Linda Cowan, Robin Filshie
Publikováno v:
Leukemialymphoma. 58(2)
Single agent azacitidine or immunomodulatory drugs are effective in myelodysplastic syndrome (MDS), with differing target mechanisms and toxicities. Objectives of this ALLG MDS3 study in clinically advanced MDS, AMML and low blast AML were to establi
Autor:
Andrew Spencer, Ian Prosser, Devinder Gill, Kenneth F. Bradstock, John V. Reynolds, Nola Kennedy, Luke Coyle, H. Miles Prince, Noemi Horvath, Andrew W. Roberts
Publikováno v:
Journal of Clinical Oncology. 27:1788-1793
Purpose Thalidomide is effective in the treatment of newly diagnosed and relapsed/refractory multiple myeloma (MM). However, the role of thalidomide in the post-autologous stem cell transplantation (ASCT) context remains unclear. This study assessed
Autor:
Andrew Spencer, S Deveridge, Ray M. Lowenthal, Henry Miles Prince, John Gibson, Kerry Taylor, Noemi Horvath, Joseph McKendrick, John Bashford, Richard Herrmann, Andrew Grigg, David Joske, Ian Prosser
Publikováno v:
Bone Marrow Transplantation. 35:971-977
In this prospective multicentre trial, 90 patients undergoing autologous stem cell transplantation (ASCT) were randomised to receive (n=43) or not receive (n=47) amifostine 910 mg/m(2) prior to melphalan 200 mg/m(2). Patients were monitored for regim
Autor:
Lye Lin Ho, Juliet Ayling, Harry J. Iland, Ian Prosser, Henry M. Kronenberg, Douglas E. Joshua
Publikováno v:
British Journal of Haematology. 112:76-80
We describe a large Syrian--Lebanese family who clinically manifest X-linked thrombocytopenia (XLT). To date, five family members have undergone splenectomy with rapid and sustained normalization of their platelet numbers. Genomic analysis demonstrat
Autor:
Edward H, Byrne, Ian, Prosser, Nira, Muttucumaru, Tanya Y, Curtis, Astrid, Wingler, Stephen, Powers, Nigel G, Halford
Publikováno v:
Plant biotechnology journal. 10(3)
A key point of regulation of protein synthesis and amino acid homoeostasis in eukaryotes is the phosphorylation of the α subunit of eukaryotic translation initiation factor 2 (eIF2α) by protein kinase general control nonderepressible (GCN)-2. In th
Publikováno v:
BJOG : an international journal of obstetrics and gynaecology. 109(2)
Objective To compare the prevalence of the Factor V Leiden mutation in children and maternal–infant pairs in pregnancies affected by severe pre-eclampsia with unmatched normal controls. Design Prospective cohort study. Setting Department of Women's
Autor:
O. Sezer, Andreas Guenther, David S. Siegel, KC Anderson, M. Klebsattel, Priscille M. Bourquelot, Jesús F. San-Miguel, Bourras-Rezki Bengoudifa, Ian Prosser, J. Bladé
Publikováno v:
Journal of Clinical Oncology. 28:8001-8001
8001 Background: Panobinostat (PAN; LBH589) is a potent pan-deacetylase inhibitor (pan-DACi) that disrupts aggresome and HSP90 function via inhibition of HDAC6, promoting cytotoxic misfolded protei...
Autor:
Jesús F. San-Miguel, Orhan Sezer, David Siegel, Andreas Guenther, Maria-Victoria Mateos, Ian Prosser, Michele Cavo, Joan Blade, Mario Boccadoro, Bourras R. Bengoudifa, Martin Klebsattel, Priscille M. Bourquelot, Kenneth C. Anderson
Publikováno v:
Blood. 114:3852-3852
Abstract 3852 Poster Board III-788 Introduction Panobinostat (LBH589) is a highly potent pan-deacetylase inhibitor (pan-DACi), inclusive of HDAC6, which disrupts aggresome function, promotes accumulation of cytotoxic misfolded protein aggregates and