ELK1 has a dual activating and repressive role in human embryonic stem cells [version 2; peer review: 2 approved]

Autor: Ian Prise, Andrew D. Sharrocks

Publikováno v: Wellcome Open Research, Vol 4 (2019)

Background: The ERK MAPK pathway plays a pivotal role in regulating numerous cellular processes during normal development and in the adult but is often deregulated in disease scenarios. One of its key nuclear targets is the transcription factor ELK1,

Externí odkaz: https://doaj.org/article/9e485af2e48a48ee8b16a283a18a2fce

Alterations in T and B cell function persist in convalescent COVID-19 patients

Autor: Halima A. Shuwa, Tovah N. Shaw, Sean B. Knight, Kelly Wemyss, Flora A. McClure, Laurence Pearmain, Ian Prise, Christopher Jagger, David J. Morgan, Saba Khan, Oliver Brand, Elizabeth R. Mann, Andrew Ustianowski, Nawar Diar Bakerly, Paul Dark, Christopher E. Brightling, Seema Brij, Timothy Felton, Angela Simpson, John R. Grainger, Tracy Hussell, Joanne E. Konkel, Madhvi Menon, Rohan Ahmed, Miriam Avery, Katharine Birchall, Evelyn Charsley, Alistair Chenery, Christine Chew, Richard Clark, Emma Connolly, Karen Connolly, Simon Dawson, Laura Durrans, Hannah Durrington, Jasmine Egan, Kara Filbey, Claire Fox, Helen Francis, Miriam Franklin, Susannah Glasgow, Nicola Godfrey, Kathryn J. Gray, Seamus Grundy, Jacinta Guerin, Pamela Hackney, Chantelle Hayes, Emma Hardy, Jade Harris, Anu John, Bethany Jolly, Verena Kästele, Gina Kerry, Sylvia Lui, Lijing Lin, Alex G. Mathioudakis, Joanne Mitchell, Clare Moizer, Katrina Moore, Stuart Moss, Syed Murtuza Baker, Rob Oliver, Grace Padden, Christina Parkinson, Michael Phuycharoen, Ananya Saha, Barbora Salcman, Nicholas A. Scott, Seema Sharma, Jane Shaw, Joanne Shaw, Elizabeth Shepley, Lara Smith, Simon Stephan, Ruth Stephens, Gael Tavernier, Rhys Tudge, Louis Wareing, Roanna Warren, Thomas Williams, Lisa Willmore, Mehwish Younas

Publikováno v: Shuwa, H A, Shaw, T N, Knight, S B, Wemyss, K, McClure, F A, Pearmain, L, Prise, I, Jagger, C, Morgan, D J, Khan, S, Brand, O, Mann, E R, Ustianowski, A, Bakerly, N D, Dark, P, Brightling, C E, Brij, S, Felton, T, Simpson, A, Grainger, J R, Hussell, T, Konkel, J E & Menon, M 2021, ' Alterations in T and B cell function persist in convalescent COVID-19 patients ', Med, vol. 2, no. 6, pp. 720-735.E4 . https://doi.org/10.1016/j.medj.2021.03.013
Shuwa, H A, Shaw, T, Knight, S, Wemyss, K, Mcclure, F, Pearmain, L, Prise, I, Jagger, C, Morgan, D, Khan, S, Brand, O, Mann, E, Ustianowski, A, Diar Bakerly, N, Dark, P, Brightling, C E, Brij, S, Felton, T, Simpson, A, Grainger, J, Hussell, T, Konkel, J & Menon, M 2021, ' Alterations in T and B cell function persist in convalescent COVID-19 patients ', Med, vol. 2, no. 6, pp. 720-+ . https://doi.org/10.1016/j.medj.2021.03.013
Med (New York, N.y.)

Background Emerging studies indicate that some COVID-19 patients suffer from persistent symptoms including breathlessness and chronic fatigue; however the long-term immune response in these patients presently remains ill-defined. Methods Here we desc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b67c5628225813d3ceef6415c87a6c6
https://hdl.handle.net/20.500.11820/bb6608a9-a1e2-4f82-b861-0aceac9047c9

Discovery of a gatekeeper residue in the C-terminal tail of the extracellular signal-regulated protein kinase 5 (ERK5)

Autor: Alan J. Whitmarsh, Gabriela Toro Tapia, Adam J. Pearson, Cathy Tournier, Ian Prise, Allan M. Jordan, Chiara Francavilla, Paul Fullwood, Emanuele Giurisato, Qiuping Xu, Michael P. Smith

Publikováno v: Pearson, A J, Fullwood, P, Tapia, G T, Prise, I, Smith, M P, Xu, Q, Jordan, A, Giurisato, E, Whitmarsh, A J, Francavilla, C & Tournier, C 2020, ' Discovery of a gatekeeper residue in the C-terminal tail of the extracellular signal-regulated protein kinase 5 (ERK5) ', International Journal of Molecular Sciences, vol. 21, no. 3, 929 . https://doi.org/10.3390/ijms21030929
International Journal of Molecular Sciences
Volume 21
Issue 3
International Journal of Molecular Sciences, Vol 21, Iss 3, p 929 (2020)

The extracellular signal-regulated protein kinase 5 (ERK5) is a non-redundant mitogen-activated protein kinase (MAPK) that exhibits a unique C-terminal extension which comprises distinct structural and functional properties. Here, we sought to elucid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fd96057873abf3d15188cd22f1efa45
https://doi.org/10.3390/ijms21030929