Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Ian Philipp"'
Autor:
Alexander M. Kulminski, Ethan Jain‐Washburn, Ian Philipp, Yury Loika, Elena Loiko, Irina Culminskaya
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 16, Iss 2, Pp n/a-n/a (2024)
Abstract INTRODUCTION The variability in apolipoprotein E (APOE) ε4‐attributed susceptibility to Alzheimer's disease (AD) across ancestries, sexes, and ages may stem from the modulating effects of other genetic variants. METHODS We examined associ
Externí odkaz:
https://doaj.org/article/f942fc4def444aaf801aad1a51aec5af
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 12, Iss 1, Pp n/a-n/a (2020)
Abstract Introduction As a multifactorial polygenic disorder, Alzheimer's disease (AD) can be associated with complex haplotypes or compound genotypes. Methods We examined associations of 4960 single nucleotide polymorphism (SNP) triples, comprising
Externí odkaz:
https://doaj.org/article/204760467c9a4268896f1487ce7e27e4
Autor:
Machtens, Dominik Alexander1,2,3 (AUTHOR), Bresch, Ian Philipp1,3 (AUTHOR), Eberhage, Jan1,3 (AUTHOR), Reubold, Thomas Frank1 (AUTHOR), Eschenburg, Susanne1,3 (AUTHOR) eschenburg.susanne@mh-hannover.de
Publikováno v:
International Journal of Molecular Sciences. Sep2022, Vol. 23 Issue 18, pN.PAG-N.PAG. 12p.
Publikováno v:
GeroScience. 45:233-247
The mechanisms of incomplete penetrance of risk-modifying impacts of apolipoprotein E (APOE) ε2 and ε4 alleles on Alzheimer’s disease (AD) have not been fully understood. We performed genome-wide analysis of differences in linkage disequilibrium
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::06c7d5723c66a15d87eb65920ff37008
https://doi.org/10.1007/s11357-022-00617-0
https://doi.org/10.1007/s11357-022-00617-0
Publikováno v:
Statistics in Medicine.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2db47649ac613762d8106a1029eda24e
https://doi.org/10.1002/sim.9747
https://doi.org/10.1002/sim.9747
Autor:
Alexander M. Kulminski, Ethan Jain‐Washburn, Ian Philipp, Liang He, Yury Loika, Elena Loiko, Olivia Bagley, Svetlana Ukraintseva, Anatoliy Yashin, Konstantin Arbeev, Eric Stallard, Mary F. Feitosa, Nicole Schupf, Kaare Christensen, Irina Culminskaya
Publikováno v:
Aging Cell. 21
Age-related diseases characteristic of post-reproductive life, aging, and life span are the examples of polygenic non-Mendelian traits with intricate genetic architectures. Polygenicity of these traits implies that multiple variants can impact their
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c0ff7575b94bde4803356c88af5bd2b
https://doi.org/10.1111/acel.13730
https://doi.org/10.1111/acel.13730
Publikováno v:
Alzheimers Dement
INTRODUCTION Despite advances, understanding the protective role of the apolipoprotein E (APOE) e2 allele in Alzheimer's disease (AD) remains elusive. METHODS We examined associations of variants comprised of the TOMM40 rs8106922 and APOE rs405509, r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d27ece2abeb62d6284664a74f4f59d38
https://doi.org/10.1002/alz.12413
https://doi.org/10.1002/alz.12413
The mechanisms of incomplete penetrance of risk modifying impacts of apolipoprotein E (APOE) ε2 and ε4 alleles on Alzheimer’s disease (AD) have not been fully understood. We performed genome-wide analysis of differences in linkage disequilibrium
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::916b928f71d00ba810ed627085b736a7
https://doi.org/10.1101/2022.06.16.22276523
https://doi.org/10.1101/2022.06.16.22276523
Publikováno v:
Alzheimer's & Dementia. 17
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::20552cbed1f1e262c457487d51bb02dc
https://doi.org/10.1002/alz.050617
https://doi.org/10.1002/alz.050617
Autor:
Alexander Kulminski, Ethan Jain-Washburn, Ian Philipp, Konstantin Arbeev, Eric Stallard, Mary Feitosa, Nicole Schupf, Kaare Christensen
Publikováno v:
Innovation in Aging. 6:442-442
Multifactorial diseases, health-related traits, and lifespan are polygenic phenotypes with complex genetic architectures. Polygenicity implies that multiple variants can impact the risks of these phenotypes independently or jointly. Recently, we show
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a753695c50c8f70e40baf2225ac71f9
https://doi.org/10.1093/geroni/igac059.1732
https://doi.org/10.1093/geroni/igac059.1732