High content screening of patient-derived cell lines highlights the potential of non-standard chemotherapeutic agents for the treatment of glioblastoma.

Autor: Kenny Kwok-Hei Yu, Jessica T Taylor, Omar N Pathmanaban, Amir Saam Youshani, Deniz Beyit, Joanna Dutko-Gwozdz, Roderick Benson, Gareth Griffiths, Ian Peers, Peter Cueppens, Brian A Telfer, Kaye J Williams, Catherine McBain, Ian D Kamaly-Asl, Brian W Bigger

Publikováno v: PLoS ONE, Vol 13, Iss 3, p e0193694 (2018)

Glioblastoma (GBM) is the most common primary brain malignancy in adults, yet survival outcomes remain poor. First line treatment is well established, however disease invariably recurs and improving prognosis is challenging. With the aim of personali

Externí odkaz: https://doaj.org/article/c0919e2e2f8a4abbb588898382f3d76c

High content screening of patient-derived cell lines highlights the potential of non-standard chemotherapeutic agents for the treatment of glioblastoma

Autor: Joanna Dutko-Gwozdz, Omar N. Pathmanaban, Peter Cueppens, Kenny Yu, Brian A. Telfer, Gareth Griffiths, Ian Peers, Roderick Benson, Kaye J. Williams, Brian W. Bigger, Deniz Beyit, Catherine McBain, Ian Kamaly-Asl, Amir Saam Youshani, Jessica T. Taylor

Publikováno v: PLoS ONE
Yu, K K H, Taylor, J T, Pathmanaban, O N, Youshani, A S, Beyit, D, Dutko-Gwozdz, J, Benson, R, Griffiths, G, Peers, I, Cueppens, P, Telfer, B A, Williams, K J, McBain, C, Kamaly-Asl, I D & Bigger, B W 2018, ' High content screening of patient-derived cell lines highlights the potential of non-standard chemotherapeutic agents for the treatment of glioblastoma ', PLoS ONE, vol. 13, no. 3, e0193694 . https://doi.org/10.1371/journal.pone.0193694
PLoS ONE, Vol 13, Iss 3, p e0193694 (2018)

Background Glioblastoma (GBM) is the most common primary brain malignancy in adults, yet survival outcomes remain poor. First line treatment is well established, however disease invariably recurs and improving prognosis is challenging. With the aim o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62738a9c8f7a45480d33d24e41cc123d
http://europepmc.org/articles/PMC5834163

Nonclinical Statistics for Pharmaceutical and Biotechnology Industries

Autor: Lanju Zhang, Max Kuhn, Ian Peers, Stan Altan

This book serves as a reference text for regulatory, industry and academic statisticians and also a handy manual for entry level Statisticians. Additionally it aims to stimulate academic interest in the field of Nonclinical Statistics and promote thi

Personalized Medicine and Proteomics: Lessons from Non-Small Cell Lung Cancer

Autor: Marie C. South, Hsiao-kun Tu, Masahiro Tsuboi, Ian Peers, Takeshi Kawamura, Fredrik Nyberg, Toshihide Nishimura, Hideo Kunito, Chris Harbron, Shingo Akimoto, Atsushi Ogiwara, Harubumi Kato, Nakata K, Yutaka Kyono, Yutaka Nishiwaki, Mitsuhiro Kanazawa, Tim Higenbottam, Takao Kawakami, Masahiro Fukuoka, György Marko-Varga, Hisae Anyoji, Shuji Hada, Kazuto Nishio, Kiyonaga Fujii, Takashi Hirano, Haiyi Jiang, Shoji Kudoh

Publikováno v: Journal of Proteome Research. 6:2925-2935

Personalized medicine allows the selection of treatments best suited to an individual patient and disease phenotype. To implement personalized medicine, effective tests predictive of response to treatment or susceptibility to adverse events are neede

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa3896c484186ab69281a15fd1b82b49
https://doi.org/10.1021/pr070046s

Use of a Canine Model of Atopic Dermatitis to Investigate the Efficacy of a CCR4 Antagonist in Allergen-Induced Skin Inflammation in a Randomized Study

Autor: Sally A. Price, Rob Riley, Mike Dymond, Alison Holt, Rosanna Marsella, Ian Peers, Jaimini Reens, Malbinder Fagura, Clare Murray, Matt Devalaraja, Adam Hargreaves, Kim Ahrens

Publikováno v: The Journal of investigative dermatology. 136(3)

Atopic dermatitis (AD) is an inflammatory skin disease characterized by infiltration of skin homing lymphocytes into the dermis. Most of these lymphocytes express the chemokine receptor CCR4, and the frequency of blood CCR4(+) lymphocytes correlates

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d4898d325601ce766d9a2e44b5bedd6
https://pubmed.ncbi.nlm.nih.gov/26876716