Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Ian P. Winters"'
Autor:
Lily M. Blair, Joseph M. Juan, Lafia Sebastian, Vy B. Tran, Wensheng Nie, Gregory D. Wall, Mehmet Gerceker, Ian K. Lai, Edwin A. Apilado, Gabriel Grenot, David Amar, Giorgia Foggetti, Mariana Do Carmo, Zeynep Ugur, Debbie Deng, Alex Chenchik, Maria Paz Zafra, Lukas E. Dow, Katerina Politi, Jonathan J. MacQuitty, Dmitri A. Petrov, Monte M. Winslow, Michael J. Rosen, Ian P. Winters
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Tumors acquire alterations in oncogenes and tumor suppressor genes in an adaptive walk through the fitness landscape of tumorigenesis. However, the interactions between oncogenes and tumor suppressor genes that shape this landscape remain po
Externí odkaz:
https://doaj.org/article/d8b8fe0a0e6941c7a811944dff8fc5cc
Autor:
Ian P. Winters, Shin-Heng Chiou, Nicole K. Paulk, Christopher D. McFarland, Pranav V. Lalgudi, Rosanna K. Ma, Leszek Lisowski, Andrew J. Connolly, Dmitri A. Petrov, Mark A. Kay, Monte M. Winslow
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
Genome editing technologies enable the rapid interrogation of genetic alterations. Here, the authors present a CRISPR/Cas9-based platform to simultaneously investigate multiple activating point mutations in de novo cancers in mice; and generate panel
Externí odkaz:
https://doaj.org/article/ec34a2e663bb4e9aa7d634750cb16aee
Autor:
Monte M. Winslow, Eric L. Snyder, Ian P. Winters, Rosanna K. Ma, Chen-Hua Chuang, Deborah R. Caswell
SELENBP1 expression correlates with NKX2-1 and NKX2-1 target gene expression in human lung adenocarcinoma, and is identified as a potential direct target of Nkx2-1 using an Nkx2-1 ChIP-seq dataset from a mouse model of lung adenocarcinoma.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41e9c6e27154adf0d8e73e7070cb6689
https://doi.org/10.1158/1541-7786.22511236
https://doi.org/10.1158/1541-7786.22511236
Autor:
Monte M. Winslow, Eric L. Snyder, Ian P. Winters, Rosanna K. Ma, Chen-Hua Chuang, Deborah R. Caswell
Selenbp1 and Nkx2-1 expression correlates in tumors from mouse lung adenocarcinoma models
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::589ff213d2bc162910f5ad3767542596
https://doi.org/10.1158/1541-7786.22511230
https://doi.org/10.1158/1541-7786.22511230
Autor:
Monte M. Winslow, Eric L. Snyder, Ian P. Winters, Rosanna K. Ma, Chen-Hua Chuang, Deborah R. Caswell
Nkx2-1 is required and sufficient for Selenbp1 expression, and Nkx2-1 and its target Selenbp1 inhibit migration independent of their effect on proliferation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0126657fa696913e39276e54e8a7d8b5
https://doi.org/10.1158/1541-7786.22511227
https://doi.org/10.1158/1541-7786.22511227
Autor:
Monte M. Winslow, Pauline Chu, Christian A. Kunder, Rosanna K. Ma, Laura Andrejka, Rui Tang, Ian P. Winters, Chuan Li, Min K. Tsai, Jennifer J. Brady, Christopher W. Murray
Summary of gene sets generated from previously published analyses of the LKB1-deficient state in human lung adenocarcinoma cell lines and tumors as well as genetically engineered mouse models.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::180f5e1c5fca29afb931367a73caadfa
https://doi.org/10.1158/2159-8290.22532464
https://doi.org/10.1158/2159-8290.22532464
Autor:
Monte M. Winslow, Eric L. Snyder, Ian P. Winters, Rosanna K. Ma, Chen-Hua Chuang, Deborah R. Caswell
Of the top-three candidate Nkx2-1 targets, Selenbp1 knock-down elicits the most dramatic increase in clonal growth ability in cell culture.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::033cf8cc84601dffa988b13b736cdfd0
https://doi.org/10.1158/1541-7786.22511239
https://doi.org/10.1158/1541-7786.22511239
Autor:
Monte M. Winslow, Eric L. Snyder, Ian P. Winters, Rosanna K. Ma, Chen-Hua Chuang, Deborah R. Caswell
Nkx2-1 is stabilized in the presence of Selenbp1.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ec355f521d6a6e7fd58c1a865777ffb
https://doi.org/10.1158/1541-7786.22511221
https://doi.org/10.1158/1541-7786.22511221
Autor:
Monte M. Winslow, Eric L. Snyder, Ian P. Winters, Rosanna K. Ma, Chen-Hua Chuang, Deborah R. Caswell
Nkx2-1 and its target Selenbp1 inhibit migration.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::896960b22579c6a213cb6eab3d4c663e
https://doi.org/10.1158/1541-7786.22511224
https://doi.org/10.1158/1541-7786.22511224
Autor:
Monte M. Winslow, Eric L. Snyder, Ian P. Winters, Rosanna K. Ma, Chen-Hua Chuang, Deborah R. Caswell
Selenbp1 cutting efficiency and expression.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65cb33ead0cc42c37b8d0df4cf6cad03
https://doi.org/10.1158/1541-7786.22511218.v1
https://doi.org/10.1158/1541-7786.22511218.v1