Zobrazeno 1 - 10
of 112
pro vyhledávání: '"Ian P. Trayer"'
Publikováno v:
Biochemistry. 42:10324-10332
Phosphorylation of the unique N-terminal extension of cardiac troponin I (TnI) by PKA modulates Ca(2+) release from the troponin complex. The mechanism by which phosphorylation affects Ca(2+) binding, however, remains unresolved. To investigate this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::830eecd28b1ad4827ff7a8f8dc0876a0
https://doi.org/10.1021/bi034495r
https://doi.org/10.1021/bi034495r
Autor:
Helen J. Coopera, Douglas G. Ward, Marjaana Nousiainen, Ian P. Trayer, Antuan Hoxha, Peter J. Derrick, Dorina Fati, Pirjo Vainiotalo, Hylary R. Trayer
Publikováno v:
European Journal of Mass Spectrometry. 8:471-481
The binding of Ca2+and of a peptide (N-TnC) to human cardiac troponin C (TnC) and its isolated N- and C-terminal domains has been characterized by electrospray ionization Fourier transform ion cyclotron resonance (ESI FT-ICR) mass spectrometry. The p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5091f992de4a902bfff9329dfb64de1
https://doi.org/10.1255/ejms.523
https://doi.org/10.1255/ejms.523
Publikováno v:
Journal of Biological Chemistry. 277:41795-41801
beta-Adrenergic stimulation of the heart results in bisphosphorylation of the N-terminal extension of cardiac troponin I (TnI). Bisphosphorylation of TnI reduces the affinity of the regulatory site on troponin C (TnC) for Ca(2+) by increasing the rat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5300365654a9d99dfbc0d018d0989050
https://doi.org/10.1074/jbc.m206744200
https://doi.org/10.1074/jbc.m206744200
Publikováno v:
European Journal of Biochemistry. 268:179-185
We used mass spectrometry to monitor cAMP-dependent protein kinase catalysed phosphorylation of human cardiac troponin I in vitro. Phosphorylation of isolated troponin I by cAMP-dependent protein kinase resulted in the covalent incorporation of phosp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::845f3cd21e104bb0aa454558dc4bcf97
https://doi.org/10.1046/j.1432-1327.2001.01871.x
https://doi.org/10.1046/j.1432-1327.2001.01871.x
Publikováno v:
Journal of Biological Chemistry. 274:18271-18277
The alkali 1-type isoforms of myosin essential light chains from vertebrate striated muscles have an additional 40 or so amino acids at their N terminus compared with the alkali 2-type. Consequently two light chain isoenzymes of myosin subfragment-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::797d55c2c5b03056ca884d611daebc26
https://doi.org/10.1074/jbc.274.26.18271
https://doi.org/10.1074/jbc.274.26.18271
Publikováno v:
European Journal of Biochemistry. 255:654-662
There are two isoforms (A1 and A2) of the myosin essential light chain (ELC) and consequently two isoenzymes of myosin subfragment 1 (S1), S1(A1) and S1(A2). The two isoenzymes differ in their kinetic properties with S1(A1) having a lower apparent Km
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f19d7dd5a06ee8decab13f69c9017a8f
https://doi.org/10.1046/j.1432-1327.1998.2550654.x
https://doi.org/10.1046/j.1432-1327.1998.2550654.x
Autor:
Ian P. Trayer, K. John Smith
Publikováno v:
Trends in Cell Biology. 7:259-263
All eukaryotic cells contain large numbers of motor proteins (kinesins, dyneins and myosins), each of which appears to carry out a specialized force-generating function within the cell. They are known to have roles in muscle contraction, ciliary move
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::366f8f6cbddc50bd6db37ad7dbe55507
https://doi.org/10.1016/s0962-8924(97)01083-0
https://doi.org/10.1016/s0962-8924(97)01083-0
Publikováno v:
Journal of Biological Chemistry. 271:16703-16711
A 25-residue peptide representing the membrane targeting N-terminal splice region of the cyclic AMP phosphodiesterase RD1 (RNPDE4A1) was synthesized, and its structure was determined by 1H NMR. Two independently folding helical regions were identifie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a66e5a26492462b60d01cf8b5ec42b5
https://doi.org/10.1074/jbc.271.28.16703
https://doi.org/10.1074/jbc.271.28.16703
Publikováno v:
European Journal of Biochemistry. 228:962-970
It is known that the phosphorylation of two serine residues on the NH2-terminal extension specific to cardiac troponin-I (Tn-I) modulates the calcium-dependent activation of the myofilaments. The process by which this occurs remains an unsolved puzzl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66443e9924dc6c887c2a050e3ce2918a
https://doi.org/10.1111/j.1432-1033.1995.0962m.x
https://doi.org/10.1111/j.1432-1033.1995.0962m.x
Autor:
Yehudi K. Levine, Olaf E. Rem, Hans C. Gerritsen, P. Schiereck, Evert L. de Beer, Ian P. Trayer, Uulke A. van der Heide
Publikováno v:
European Biophysics Journal. 23:369-378
A fluorescence depolarization study of the orientational distribution of crossbridges in dye-labelled muscle fibres is presented. The characterization of this distribution is important since the rotation of crossbridges is a key element in the theory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b4eb61bf500a90e6fb2e162404d5bf3
https://doi.org/10.1007/bf00188661
https://doi.org/10.1007/bf00188661