Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Ian P. Barrett"'
Autor:
Stephen Bonner, Ian P. Barrett, Cheng Ye, Rowan Swiers, Ola Engkvist, Charles Tapley Hoyt, William L. Hamilton
Publikováno v:
Artificial Intelligence in the Life Sciences, Vol 2, Iss , Pp 100036- (2022)
Knowledge Graphs (KG) and associated Knowledge Graph Embedding (KGE) models have recently begun to be explored in the context of drug discovery and have the potential to assist in key challenges such as target identification. In the drug discovery do
Externí odkaz:
https://doaj.org/article/6d77b82e3e694199962f332bc8954456
Autor:
Lewis H. Mervin, Maria-Anna Trapotsi, Avid M. Afzal, Ian P. Barrett, Andreas Bender, Ola Engkvist
Publikováno v:
Journal of Cheminformatics, Vol 13, Iss 1, Pp 1-17 (2021)
Abstract Measurements of protein–ligand interactions have reproducibility limits due to experimental errors. Any model based on such assays will consequentially have such unavoidable errors influencing their performance which should ideally be fact
Externí odkaz:
https://doaj.org/article/82bc433180a3454296e12eb40f3f71c4
Small gene networks delineate immune cell states and characterize immunotherapy response in melanoma
Autor:
Donagh Egan, Martina Kreileder, Myriam Nabhan, Luis F. Iglesias-Martinez, Simon J. Dovedi, Viia Valge-Archer, Amit Grover, Robert W. Wilkinson, Timothy Slidel, Claus Bendtsen, Ian P. Barrett, Donal J. Brennan, Walter Kolch, Vadim Zhernovkov
Publikováno v:
Cancer Immunology Research.
Single-cell technologies have elucidated mechanisms responsible for immune checkpoint inhibitor (ICI) response, but are not amenable to a clinical diagnostic setting. In contrast, bulk RNA sequencing (RNA-seq) is now routine for research and clinical
Autor:
Kristoffer Valerie, Stephen T. Durant, Martin Pass, Kan Chen, Yingchun Wang, Tianwei Zhang, Li Zheng, Ian P. Barrett, Aaron Smith, Joanne Wilson, Nicola Colclough, Jason Kettle, Sebastien L. Degorce, Bernard Barlaam, Nitai Mukhopadhyay, Jason M. Beckta, Jenna Kahn, Laura Biddlestone-Thorpe, Nicholas C.K. Valerie, Amrita Sule, Thomas A. Hunt, Kurt G. Pike, Alan Lau, Jennifer Vincent, Bhavika Patel, Andrew G. Thomason, Antonio Garcia-Trinidad, Lucy C. Riches, Elaine B. Cadogan, Paul Farrington, Rajesh Odedra, Victoria Sheridan, Gareth Hughes, Syed F. Ahmad, Jasmine Allen, Jeremy Karlin
Supplementary Information
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::393ee016739d4d6ff0e2ec657589845d
https://doi.org/10.1158/1535-7163.22504764.v1
https://doi.org/10.1158/1535-7163.22504764.v1
Autor:
Kristoffer Valerie, Stephen T. Durant, Martin Pass, Kan Chen, Yingchun Wang, Tianwei Zhang, Li Zheng, Ian P. Barrett, Aaron Smith, Joanne Wilson, Nicola Colclough, Jason Kettle, Sebastien L. Degorce, Bernard Barlaam, Nitai Mukhopadhyay, Jason M. Beckta, Jenna Kahn, Laura Biddlestone-Thorpe, Nicholas C.K. Valerie, Amrita Sule, Thomas A. Hunt, Kurt G. Pike, Alan Lau, Jennifer Vincent, Bhavika Patel, Andrew G. Thomason, Antonio Garcia-Trinidad, Lucy C. Riches, Elaine B. Cadogan, Paul Farrington, Rajesh Odedra, Victoria Sheridan, Gareth Hughes, Syed F. Ahmad, Jasmine Allen, Jeremy Karlin
U87/Centrin2-EGFP/H2B-mCherry/puro cells were seeded on dishes with cover slip bottoms, treated with AZ32 (3 uM), and irradiated (5 Gy). Time-lapse videos were recorded intermittently (every 7 min) over 16 hrs. Treatment results in 11% aberrant mitos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37d9bad2471d6722b3a914316ea1d053
https://doi.org/10.1158/1535-7163.22504755
https://doi.org/10.1158/1535-7163.22504755
Autor:
Kristoffer Valerie, Stephen T. Durant, Martin Pass, Kan Chen, Yingchun Wang, Tianwei Zhang, Li Zheng, Ian P. Barrett, Aaron Smith, Joanne Wilson, Nicola Colclough, Jason Kettle, Sebastien L. Degorce, Bernard Barlaam, Nitai Mukhopadhyay, Jason M. Beckta, Jenna Kahn, Laura Biddlestone-Thorpe, Nicholas C.K. Valerie, Amrita Sule, Thomas A. Hunt, Kurt G. Pike, Alan Lau, Jennifer Vincent, Bhavika Patel, Andrew G. Thomason, Antonio Garcia-Trinidad, Lucy C. Riches, Elaine B. Cadogan, Paul Farrington, Rajesh Odedra, Victoria Sheridan, Gareth Hughes, Syed F. Ahmad, Jasmine Allen, Jeremy Karlin
U87/shp53/Centrin2-EGFP/H2B-mCherry/shp53 cells were seeded on dishes with cover slip bottoms and irradiated (5 Gy). Time-lapse videos were recorded intermittently (every 7 min) over 16 hrs. Treatment results in 12% aberrant mitoses (see Fig. 3F).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e59ae0a5bd1c69ae1a3cc400be18041
https://doi.org/10.1158/1535-7163.22504752
https://doi.org/10.1158/1535-7163.22504752
Autor:
Kristoffer Valerie, Stephen T. Durant, Martin Pass, Kan Chen, Yingchun Wang, Tianwei Zhang, Li Zheng, Ian P. Barrett, Aaron Smith, Joanne Wilson, Nicola Colclough, Jason Kettle, Sebastien L. Degorce, Bernard Barlaam, Nitai Mukhopadhyay, Jason M. Beckta, Jenna Kahn, Laura Biddlestone-Thorpe, Nicholas C.K. Valerie, Amrita Sule, Thomas A. Hunt, Kurt G. Pike, Alan Lau, Jennifer Vincent, Bhavika Patel, Andrew G. Thomason, Antonio Garcia-Trinidad, Lucy C. Riches, Elaine B. Cadogan, Paul Farrington, Rajesh Odedra, Victoria Sheridan, Gareth Hughes, Syed F. Ahmad, Jasmine Allen, Jeremy Karlin
U87/Centrin2-EGFP/H2B-mCherry/puro cells were seeded on dishes with cover slip bottoms and irradiated (5 Gy). Time-lapse videos were recorded intermittently (every 7 min) over 16 hrs. Treatment results in 2.7% aberrant mitoses (see Fig. 3F).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8597de5b360dbd2701d63db0a2d2f9a5
https://doi.org/10.1158/1535-7163.22504758
https://doi.org/10.1158/1535-7163.22504758
Autor:
Kristoffer Valerie, Stephen T. Durant, Martin Pass, Kan Chen, Yingchun Wang, Tianwei Zhang, Li Zheng, Ian P. Barrett, Aaron Smith, Joanne Wilson, Nicola Colclough, Jason Kettle, Sebastien L. Degorce, Bernard Barlaam, Nitai Mukhopadhyay, Jason M. Beckta, Jenna Kahn, Laura Biddlestone-Thorpe, Nicholas C.K. Valerie, Amrita Sule, Thomas A. Hunt, Kurt G. Pike, Alan Lau, Jennifer Vincent, Bhavika Patel, Andrew G. Thomason, Antonio Garcia-Trinidad, Lucy C. Riches, Elaine B. Cadogan, Paul Farrington, Rajesh Odedra, Victoria Sheridan, Gareth Hughes, Syed F. Ahmad, Jasmine Allen, Jeremy Karlin
Inhibition of ataxia-telangiectasia mutated (ATM) during radiotherapy of glioblastoma multiforme (GBM) may improve tumor control by short-circuiting the response to radiation-induced DNA damage. A major impediment for clinical implementation is that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dd6452a1cb4c3980123b06194a75b60c
https://doi.org/10.1158/1535-7163.c.6537843.v1
https://doi.org/10.1158/1535-7163.c.6537843.v1
Autor:
Stephen Bonner, Ian P Barrett, Cheng Ye, Rowan Swiers, Ola Engkvist, Andreas Bender, Charles Tapley Hoyt, William L Hamilton
Publikováno v:
Briefings in Bioinformatics. 23
Drug discovery and development is a complex and costly process. Machine learning approaches are being investigated to help improve the effectiveness and speed of multiple stages of the drug discovery pipeline. Of these, those that use Knowledge Graph
Publikováno v:
Briefings in Bioinformatics. 23
Adoption of recently developed methods from machine learning has given rise to creation of drug-discovery knowledge graphs (KG) that utilize the interconnected nature of the domain. Graph-based modelling of the data, combined with KG embedding (KGE)