Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Ian P. Andrews"'
Autor:
Erica J. Zheng, Ian W. Andrews, Alexandra T. Grote, Abigail L. Manson, Miguel A. Alcantar, Ashlee M. Earl, James J. Collins
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Antibiotic tolerance, or the ability of bacteria to survive antibiotic treatment in the absence of genetic resistance, often involves a low metabolic state. Here, Zheng et al. show that tolerance does not readily evolve against antibiotics whose effi
Externí odkaz:
https://doaj.org/article/7c9a36880bc84974902377009584c79c
Publikováno v:
ChemCatChem
We have developed a phosphine-catalyzed (4+1) annulative rearrangement for the preparation of 3-pyrrolines from allenylic carbamates via phosphonium diene intermediates. We employed this methodology to synthesize an array of 1,3-disubstituted- and 1,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::857e58715714cfd5b719d47c67438157
https://pubmed.ncbi.nlm.nih.gov/34447481
https://pubmed.ncbi.nlm.nih.gov/34447481
Autor:
Matthew Whiting, Daniel R. Tray, Charles A. Goss, Neil R. Curtis, Yangmu Chloe Liu, Mark J. Hughes, David C. Leitch, Brian M. Roesch, Charles E. Wade, Anna L. Dunn, Kenneth Arrington, Ian P. Andrews, John Jin Lim
Publikováno v:
Organic Process Research & Development. 24:1927-1937
This paper describes recent efforts to apply flow technology in the preparation of the key amino alcohol intermediate 3b so as to address manufacturability issues present in the batch process of a ...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7650caff8faf6434d25de2cac9a4c061
https://doi.org/10.1021/acs.oprd.9b00478
https://doi.org/10.1021/acs.oprd.9b00478
Autor:
Ian P. Andrews, John M. Ketcham, Megan L. Peach, Noemi Kedei, Nancy E. Lewin, Peter M. Blumberg, Michael J. Krische
Publikováno v:
Journal of the American Chemical Society
The seco-B-ring bryostatin analogue, macrodiolide WN-1, was prepared in 17 steps (longest linear sequence) and 30 total steps with three bonds formed via hydrogen-mediated C-C coupling. This synthetic route features a palladium-catalyzed alkoxycarbon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76ffb15afc25c5c7ac10006b2034efd3
http://europepmc.org/articles/PMC4183601
http://europepmc.org/articles/PMC4183601
Autor:
Gary T. Borrett, Graham R. Slater, Stephen A. Hermitage, Ian P. Andrews, Peter M. Kincey, Smith Neil, Mahesh J. Sanganee, Geracimos Rassias
Publikováno v:
Organic Process Research & Development. 13:774-780
The original medicinal chemistry synthesis of an iNOS inhibitor presented several challenges that had to be overcome in order to constitute a supply route suitable for operation on a multikilo scal...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d72df24bc2bd3724f8c202662671f764
https://doi.org/10.1021/op900108b
https://doi.org/10.1021/op900108b
Autor:
Ian P. Andrews, John S. Carey, Richard J. Atkins, David O. Morgan, Gary F. Breen, Andrew S. Wells, Timothy Charles Walsgrove, Stephen A. Smith, Amin Shamji, Michael Anthony Forth, Andrew C. Share
Publikováno v:
Organic Process Research & Development. 7:655-662
The development of an efficient manufacturing route to 2,3,4,5-tetrahydro-4-methyl-3-oxo-1H-1,4-benzodiazepine-2-acetic acid methyl ester SB-235349, a key intermediate in the synthesis of lotrafiban is described. The synthesis starts with 2-nitrobenz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c3d554bc2bf2f02227e29422210101c
https://doi.org/10.1021/op034024c
https://doi.org/10.1021/op034024c
Autor:
Ohyun Kwon, Ian P. Andrews
Publikováno v:
Organic Synth
Organic Syntheses
Organic Syntheses
Ethyl 5,5-dimethylhexa-2,3-dienoate Ethyl (triphenylphosphoranylidene)acetate 3,3-Dimethylbutyryl chloride Triethylamine Ethyl 5-(tert-butyl)-2-phenyl-1-tosyl-3-pyrroline-3-carboxylate (E)-N-Benzylidene-4-methylbenzenesulfonamide Tributylphosphine Ke
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1878c85d1a942b332c6d7cd6c2d6c58c
https://pubmed.ncbi.nlm.nih.gov/32675890
https://pubmed.ncbi.nlm.nih.gov/32675890
Publikováno v:
Synthetic Communications. 31:2323-2327
Methyllithium, in the presence of excess methyl iodide, can be used to convert suitably substituted aromatic bromides to the corresponding toluenes under mild conditions and in high yield.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c17494b5e21a8ca9babe1618c6ec8646
https://doi.org/10.1081/scc-100104832
https://doi.org/10.1081/scc-100104832
Publikováno v:
Tetrahedron Letters. 41:6237-6240
A number of aryl halides (X=Cl, Br, I) can be converted to the corresponding toluenes in an operationally simple manner using trimethylboroxine (TMB) as a partner for palladium-catalysed Suzuki–Miyaura coupling.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d429b0853c4042da025c2a13b05dbe3a
https://doi.org/10.1016/s0040-4039(00)01038-8
https://doi.org/10.1016/s0040-4039(00)01038-8
Autor:
Ohyun Kwon, Ian P. Andrews
Publikováno v:
Tetrahedron Letters. 49:7097-7099
The palladium-catalyzed hydrostannation of acetylenes is widely exploited in organic synthesis as a means of forming vinyl stannanes for use in palladium-catalyzed cross-coupling reactions. Application of this methodology to ethyl ethynyl ether resul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b584296940c867b08a8a7f6496a2c215
https://doi.org/10.1016/j.tetlet.2008.09.147
https://doi.org/10.1016/j.tetlet.2008.09.147