Genomic Evolution and Transcriptional Changes in the Evolution of Prostate Cancer into Neuroendocrine and Ductal Carcinoma Types

Autor: Srinivasa R. Rao, Andrew Protheroe, Lucia Cerundolo, David Maldonado-Perez, Lisa Browning, Alastair D. Lamb, Richard J. Bryant, Ian G. Mills, Dan J. Woodcock, Freddie C. Hamdy, Ian P. M. Tomlinson, Clare Verrill

Publikováno v: International Journal of Molecular Sciences, Vol 24, Iss 16, p 12722 (2023)

Prostate cancer is typically of acinar adenocarcinoma type but can occasionally present as neuroendocrine and/or ductal type carcinoma. These are associated with clinically aggressive disease, and the former often arises on a background of androgen d

Externí odkaz: https://doaj.org/article/3dc858a542854e47aba148547ce1d7ed

A sensitive and affordable multiplex RT-qPCR assay for SARS-CoV-2 detection.

Autor: Martin A M Reijns, Louise Thompson, Juan Carlos Acosta, Holly A Black, Francisco J Sanchez-Luque, Austin Diamond, David A Parry, Alison Daniels, Marie O'Shea, Carolina Uggenti, Maria C Sanchez, Alan O'Callaghan, Michelle L L McNab, Martyna Adamowicz, Elias T Friman, Toby Hurd, Edward J Jarman, Frederic Li Mow Chee, Jacqueline K Rainger, Marion Walker, Camilla Drake, Dasa Longman, Christine Mordstein, Sophie J Warlow, Stewart McKay, Louise Slater, Morad Ansari, Ian P M Tomlinson, David Moore, Nadine Wilkinson, Jill Shepherd, Kate Templeton, Ingolfur Johannessen, Christine Tait-Burkard, Jürgen G Haas, Nick Gilbert, Ian R Adams, Andrew P Jackson

Publikováno v: PLoS Biology, Vol 18, Iss 12, p e3001030 (2020)

With the ongoing COVID-19 (Coronavirus Disease 2019) pandemic, caused by the novel coronavirus SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2), there is a need for sensitive, specific, and affordable diagnostic tests to identify infected

Externí odkaz: https://doaj.org/article/cd5310c0965d4b4f882567dc2bff3e3b

The effects of mutational processes and selection on driver mutations across cancer types

Autor: Daniel Temko, Ian P. M. Tomlinson, Simone Severini, Benjamin Schuster-Böckler, Trevor A. Graham

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)

A central question in cancer research is how specific driver mutations are acquired and maintained during cancer development. Here Temko et al. use public sequencing data to infer the effect of mutation and selection on a set of driver mutations and

Externí odkaz: https://doaj.org/article/2f20429856604bb1a50d0d6d22d58faa

Supplementary Tables 1-2 from PHLDA1 Expression Marks the Putative Epithelial Stem Cells and Contributes to Intestinal Tumorigenesis

Autor: Oliver M. Sieber, Elizabeth Vincan, Dustin J. Flanagan, Bruno Catimel, Nicole Church, Maree C. Faux, Francesca Walker, Richard J. Simpson, Oliver K. Bernhard, Ian P. M. Tomlinson, Stefania Segditsas, Simon J. Leedham, Richard Poulsom, Rosemary E. Jeffery, Matthias Ernst, Toby J. Phesse, Robert G. Ramsay, Jordane Malaterre, Lara Lipton, Peter Gibbs, Nicholas I. Fleming, Shan Li, Robert N. Jorissen, Cary Tsui, Carla D'Andreti, Michael Christie, Anuratha Sakthianandeswaren

Supplementary Tables 1-2 from PHLDA1 Expression Marks the Putative Epithelial Stem Cells and Contributes to Intestinal Tumorigenesis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::598e9420b5799dae157793e4688f3009
https://doi.org/10.1158/0008-5472.22388879

Phenome-wide association study (PheWAS) of colorectal cancer risk SNP effects on health outcomes in UK Biobank

Autor: Xiaomeng Zhang, Xue Li, Yazhou He, Philip J. Law, Susan M. Farrington, Harry Campbell, Ian P. M. Tomlinson, Richard S. Houlston, Malcolm G. Dunlop, Maria Timofeeva, Evropi Theodoratou

Publikováno v: Zhang, X, Li, X, He, Y, Law, P, Farrington, S M, Campbell, H, Tomlinson, I P M, Houlston, R S, Dunlop, M G, Timofeeva, M & Theodoratou, E 2021, ' Phenome-wide association study (PheWAS) of colorectal cancer risk SNP effects on health outcomes in UK Biobank ', British Journal of Cancer . https://doi.org/10.1038/s41416-021-01655-9

Background Associations between colorectal cancer (CRC) and other health outcomes have been reported, but these may be subject to biases, or due to limitations of observational studies. Methods We set out to determine whether genetic predisposition t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1688edbfc2a8f370a952d0fc87cdad09
https://doi.org/10.1038/s41416-021-01655-9