Zobrazeno 1 - 10
of 168
pro vyhledávání: '"Ian N, Clarke"'
Autor:
Mario Mietzsch, Shweta Kailasan, Antonette Bennett, Paul Chipman, Bentley Fane, Juha T. Huiskonen, Ian N. Clarke, Robert McKenna
Publikováno v:
Viruses, Vol 16, Iss 7, p 1103 (2024)
Spiroplasma virus 4 (SpV4) is a bacteriophage of the Microviridae, which packages circular ssDNA within non-enveloped T = 1 icosahedral capsids. It infects spiroplasmas, which are known pathogens of honeybees. Here, the structure of the SpV4 virion i
Externí odkaz:
https://doaj.org/article/d837cfe946374f07a31dec158ee1e2b4
Autor:
Sarah A. Pearson, David W. Cleary, Nicholas R. Thomson, David J. Lampe, Ian N. Clarke, Colette E. O'Neill, Jade Forster, Rachel J. Skilton
Publikováno v:
Wellcome Open Research, Vol 6 (2021)
Background: Chlamydia trachomatis is a prolific human pathogen that can cause serious long-term conditions if left untreated. Recent developments in Chlamydia genetics have opened the door to conducting targeted and random mutagenesis experiments to
Externí odkaz:
https://doaj.org/article/71bf456426164945a72f754b32424d84
Publikováno v:
Wellcome Open Research, Vol 6 (2021)
Background Genetic systems have been developed for Chlamydia but the extremely low transformation frequency remains a significant bottleneck. Our goal is to develop a self-replicating transposon delivery vector for C. trachomatis which can be expande
Externí odkaz:
https://doaj.org/article/02d4ed1c1f324244a0b5883d3455bfa8
Publikováno v:
PLoS ONE, Vol 16, Iss 7, p e0254233 (2021)
BackgroundLymphogranuloma venereum (LGV) is caused by Chlamydia trachomatis strains with ompA genotypes L1 to L3. An LGV epidemic associated with the L2b genotype has emerged in the past few decades amongst men who have sex with men (MSM). C. trachom
Externí odkaz:
https://doaj.org/article/0bed3fd6977d4bf58fd588efe7591aa6
Publikováno v:
PLoS ONE, Vol 15, Iss 5, p e0233298 (2020)
BACKGROUND:Evolutionary studies have been conducted that have investigated the chromosomal variance in the genus of Chlamydia. However, no all-encompassing genus-wide comparison has been performed on the plasmid. Therefore, there is a gap in the curr
Externí odkaz:
https://doaj.org/article/82889e1194d246c5bc77a77740de9c91
Autor:
Patiyan Andersson, Simon R. Harris, Helena M. B. Seth Smith, James Hadfield, Colette O’Neill, Lesley T. Cutcliffe, Fiona P. Douglas, L. Valerie Asche, John D. Mathews, Susan I. Hutton, Derek S. Sarovich, Steven Y. C. Tong, Ian N. Clarke, Nicholas R. Thomson, Philip M. Giffard
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
Chlamydia trachomatis isolates causing a blinding disease (trachoma) form a single lineage that is different from the lineages causing urogenital infections. Here, Andersson et al. show however that trachoma isolates from Australia are more closely r
Externí odkaz:
https://doaj.org/article/b0565474b8e64c95a95c4c3f688c0170
Autor:
Charlotte A. Jones, James Hadfield, Nicholas R. Thomson, David W. Cleary, Peter Marsh, Ian N. Clarke, Colette E. O’Neill
Publikováno v:
Microorganisms, Vol 8, Iss 3, p 373 (2020)
Chlamydia trachomatis is an obligate intracellular pathogen of humans, causing both the sexually transmitted infection, chlamydia, and the most common cause of infectious blindness, trachoma. The majority of sequenced C. trachomatis clinical isolates
Externí odkaz:
https://doaj.org/article/6bed965348694a2fb41577a1f77f71de
Autor:
Kensuke Shima, Maximilian Wanker, Rachel J. Skilton, Lesley T. Cutcliffe, Christiane Schnee, Thomas A. Kohl, Stefan Niemann, Javier Geijo, Matthias Klinger, Peter Timms, Thomas Rattei, Konrad Sachse, Ian N. Clarke, Jan Rupp
Publikováno v:
mSphere, Vol 3, Iss 5 (2018)
ABSTRACT We demonstrate the genetic transformation of Chlamydia pneumoniae using a plasmid shuttle vector system which generates stable transformants. The equine C. pneumoniae N16 isolate harbors the 7.5-kb plasmid pCpnE1. We constructed the plasmid
Externí odkaz:
https://doaj.org/article/2d4f7be506794708bdf524dd71f61dc5
Autor:
Rachel J. Skilton, Yibing Wang, Colette O'Neill, Simone Filardo, Peter Marsh, Angèle Bénard, Nicholas R. Thomson, Kyle H. Ramsey, Ian N. Clarke
Publikováno v:
Wellcome Open Research, Vol 3 (2018)
Background: Research in chlamydial genetics is challenging because of its obligate intracellular developmental cycle. In vivo systems exist that allow studies of different aspects of basic biology of chlamydiae, the murine Chlamydia muridarum model i
Externí odkaz:
https://doaj.org/article/cad860f524264d25881cd4f138c5f176
Autor:
Paul J S Skipp, Chris Hughes, Thérèse McKenna, Richard Edwards, James Langridge, Nicholas R Thomson, Ian N Clarke
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0149011 (2016)
The obligate intracellular developmental cycle of Chlamydia trachomatis presents significant challenges in defining its proteome. In this study we have applied quantitative proteomics to both the intracellular reticulate body (RB) and the extracellul
Externí odkaz:
https://doaj.org/article/90a1d0c1527b4141aea276c2bbc11ce2