Inhibition of FGF receptor blocks adaptive resistance to RET inhibition in CCDC6-RET-rearranged thyroid cancer

Autor: Renuka Raman, Jacques A. Villefranc, Timothy M. Ullmann, Jessica Thiesmeyer, Viviana Anelli, Jun Yao, James R. Hurley, Chantal Pauli, Rohan Bareja, Kenneth Wha Eng, Princesca Dorsaint, David C. Wilkes, Shaham Beg, Sarah Kudman, Reid Shaw, Michael Churchill, Adnan Ahmed, Laurel Keefer, Ian Misner, Donna Nichol, Naveen Gumpeni, Theresa Scognamiglio, Mark A. Rubin, Carla Grandori, James Patrick Solomon, Wei Song, Juan Miguel Mosquera, Noah Dephoure, Andrea Sboner, Olivier Elemento, Yariv Houvras

Publikováno v: Raman, Renuka; Villefranc, Jacques A; Ullmann, Timothy M; Thiesmeyer, Jessica; Anelli, Viviana; Yao, Jun; Hurley, James R; Pauli, Chantal; Bareja, Rohan; Wha Eng, Kenneth; Dorsaint, Princesca; Wilkes, David C; Beg, Shaham; Kudman, Sarah; Shaw, Reid; Churchill, Michael; Ahmed, Adnan; Keefer, Laurel; Misner, Ian; Nichol, Donna; ... (2022). Inhibition of FGF receptor blocks adaptive resistance to RET inhibition in CCDC6-RET-rearranged thyroid cancer. Journal of experimental medicine, 219(6) Rockefeller University Press 10.1084/jem.20210390

Genetic alterations in RET lead to activation of ERK and AKT signaling and are associated with hereditary and sporadic thyroid cancer and lung cancer. Highly selective RET inhibitors have recently entered clinical use after demonstrating efficacy in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b43e8c8db5b3a15fed3b2912932d0a40
https://pubmed.ncbi.nlm.nih.gov/35510953

The Secreted Proteins of Achlya hypogyna and Thraustotheca clavata Identify the Ancestral Oomycete Secretome and Reveal Gene Acquisitions by Horizontal Gene Transfer

Autor: Christopher E. Lane, Ian Misner, Thomas A. Richards, Nic Blouin, Guy Leonard

Publikováno v: Genome Biology and Evolution

Saprotrophic and parasitic microorganisms secrete proteins into the environment to breakdown macromolecules and obtain nutrients. The molecules secreted are collectively termed the "secretome" and the composition and function of this set of proteins

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4353a0c65b9399ea80a9ad88373ae12e
https://doi.org/10.1093/gbe/evu276

Mitochondrial Genome Sequences and Comparative Genomics ofAchlya hypogynaandThraustotheca clavata

Autor: Christopher E. Lane, Megan A. O’Brien, Ian Misner

Publikováno v: Journal of Eukaryotic Microbiology. 61:146-154

As a lineage, oomycetes have adapted to a wide range of lifestyles. Although the common ancestor of the group was likely a marine pathogen, extant members inhabit a spectrum from free-living saprobes to obligate biotrophs. The mitochondrial genomes o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2380a79a4ef365780b4307da3d258f9
https://doi.org/10.1111/jeu.12092

Sequence Comparative Analysis Using Networks: Software for Evaluating De Novo Transcript Assembly from Next-Generation Sequencing

Autor: Philippe Lopez, Eric Bapteste, Sébastien Halary, Cédric Bicep, Christopher E. Lane, Ian Misner

Publikováno v: Molecular Biology and Evolution
Molecular Biology and Evolution, Oxford University Press (OUP), 2013, 30 (8), pp.1975-1986. ⟨10.1093/molbev/mst087⟩
Molecular Biology and Evolution, 2013, 30 (8), pp.1975-1986. ⟨10.1093/molbev/mst087⟩

International audience; DNA sequencing technology is becoming more accessible to a variety of researchers as costs continue to decline. As researchers begin to sequence novel transcriptomes, most of these data sets lack a reference genome and will ha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::867e7b89ffafcdf5f5c24698b1adfab6
https://hal.archives-ouvertes.fr/hal-01544800

Structure and biosynthesis of amphidinol 17, a hemolytic compound from Amphidinium carterae

Autor: Jeffrey L. C. Wright, Carmelo R. Tomas, Ryan M. Van Wagoner, Ian Misner, Yanhui Meng

Publikováno v: Journal of natural products. 73(3)

Amphidinol 17 (AM17; 1), a novel amphidinol, has been isolated from a Bahamas strain of Amphidinium carterae. This new congener contains the signature hairpin region and a Delta(6) polyene arm, whereas the polyol arm is distinct from those of other a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69726da8138e73c526e899d8f41cee7d
https://pubmed.ncbi.nlm.nih.gov/20108948