Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Ian Millichip"'
Autor:
Elizabeth Claire Akam, Tim Luker, Ian Millichip, Stephen Thom, Rukhsana Tasneem Mohammed, Carol Sargent, Stuart W. Paine, Roger Bonnert, Steve Brough, Iain G. Dougall, Phillip A. Abbott, Jerzy Schmidt, Anil Patel, Gary Pairaudeau, Andrew M. Davis, Thomas AstraZeneca R D Charnwood Dept Mcinally
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:3616-3621
A novel series of biaryl phenoxyacetic acids was discovered as potent, selective antagonists of the chemoattractant receptor-homologous expressed on Th2 lymphocytes receptor (CRTh2 or DP2). A hit compound 4 was discovered from high throughput screeni
Publikováno v:
Tetrahedron Letters. 48:8878-8882
A one-pot reaction of carboxylic acids with sulfonamides to afford sulfonylureas is described.
Autor:
David Cox, Alan V. Wallace, Anthony Ronald Cook, Anders Åberg, and Alan C. Tinker, John A. Tainer, David Cheshire, Haydn Beaton, Phil Mallinder, Ian Millichip, David J. Nicholls, Stephen A. St-Gallay, Sally L. Cooper, Robin J. Rosenfeld, Stephen Connolly, Andrew S. Arvai, Peter Hamley
Publikováno v:
Journal of Medicinal Chemistry. 47:3320-3323
4-Methylaminopyridine (4-MAP) (5) is a potent but nonselective nitric oxide synthase (NOS) inhibitor. While simple N-methylation in this series results in poor activity, more elaborate N-substitution such as with 4-piperidine carbamate or amide resul
Autor:
Rupert P. Austin, Karl Edman, Hitesh J. Sanganee, Raj Beri, Peter Cage, Christopher A. Luckhurst, Jason Breed, Ian Millichip, Victor I. C. Oreffo, Bob Thong, Antonio Mete, Kamaldeep K. Chohan, Steve T. Harper, Alan V. Wallace, Elizabeth Kinchin, Lisa Wissler, Judit E. Debreczeni, Andrew Mather, Anna-Karin Tidén, Mark Furber, Rhonan Ford, Ray Hutchinson, Simon Barber, Philip Gardiner, Linda Stein
Publikováno v:
Journal of medicinal chemistry. 57(6)
A lead generation and optimization program delivered the highly selective and potent CatC inhibitor 10 as an in vivo tool compound and potential development candidate. Structural studies were undertaken to generate SAR understanding.
Autor:
Stephen Connolly, Nigel Gensmantel, Peter Hamley, Richard P. Harrison, Paul Hartopp, Nigel Boughton-Smith, Timothy Nicholas Birkinshaw, Antonio Mete, Haydn Beaton, Sally L. Cooper, Austen Pimm, David Cheshire, Gunilla Andersson, Alan V. Wallace, Anders Åberg, Paul D. Leeson, John Dixon, David Cox, Timothy Jon Luker, Helena Käck, Ian Millichip, Steve St-Gallay, David J. Nicholls, Anne Cooper, Glen Andrews, Tony R. Cook
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(8)
By careful analysis of experimental X-ray ligand crystallographic protein data across several inhibitor series we have discovered a novel, potent and selective series of iNOS inhibitors exemplified by compound 8.
Publikováno v:
ChemInform. 39
A one-pot reaction of carboxylic acids with sulfonamides to afford sulfonylureas is described.