Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Ian McFadzean"'
Autor:
Pratish Thakore, James E. Clark, Aisah A. Aubdool, Dibesh Thapa, Anna Starr, Paul A. Fraser, Keith Farrell-Dillon, Elizabeth S. Fernandes, Ian McFadzean, Susan D. Brain
Publikováno v:
Biomolecules, Vol 14, Iss 4, p 442 (2024)
TRPC5 is a non-selective cation channel that is expressed in cardiomyocytes, but there is a lack of knowledge of its (patho)physiological role in vivo. Here, we examine the role of TRPC5 on cardiac function under basal conditions and during cardiac h
Externí odkaz:
https://doaj.org/article/8e0bbe9f106945c5825424a3000f4ab8
Publikováno v:
Pharmacology Research & Perspectives, Vol 9, Iss 4, Pp n/a-n/a (2021)
Abstract The British Pharmacological Society (BPS) developed a new core curriculum for undergraduate pharmacology degrees. To do this, a modification of the Delphi Process was used. Initially, a pharmacology educator workshop was hosted to explore th
Externí odkaz:
https://doaj.org/article/5c1179288f1d4e3e95199fb852d60116
Publikováno v:
Pharmacology Research & Perspectives
Pharmacology Research & Perspectives, Vol 9, Iss 4, Pp n/a-n/a (2021)
Pharmacology Research & Perspectives, Vol 9, Iss 4, Pp n/a-n/a (2021)
The British Pharmacological Society (BPS) developed a new core curriculum for undergraduate pharmacology degrees. To do this, a modification of the Delphi Process was used. Initially, a pharmacology educator workshop was hosted to explore the core at
Autor:
Yahya M Bahnasi, Jing Li, Karen E. Porter, Chris Peers, Paul Emery, Hugh A. Pearson, Anne English, Dayne Beccano-Kelly, Jacqueline Naylor, Alex Cheong, Ian McFadzean, Yasser Majeed, Mark L. Dallas, Carol J. Milligan, Nikita Gamper, Fanning Zeng, Piruthivi Sukumar, Xing Liu, Lin-Hua Jiang, David J. Beech, Brian Robertson, Andrew M. Smith
Publikováno v:
Nature Protocols. 4:244-255
Multi-well robotic planar patch-clamp has become common in drug development and safety programmes because it enables efficient and systematic testing of compounds against ion channels during voltage-clamp. It has not, however, been adopted significan
Autor:
Nelson P. Barrera, Yasin Shaifta, Ian McFadzean, Jeremy P.T. Ward, Robert M. Henderson, J. Michael Edwardson
Publikováno v:
Biochemical and Biophysical Research Communications. 358:1086-1090
Several members of the transient receptor potential (TRP) channel superfamily have been shown to assemble as tetramers. Here we have determined the subunit stoichiometry of the transient receptor potential M8 (TRPM8) channel using atomic force micros
Publikováno v:
British Journal of Pharmacology. 139:1532-1538
The aim of this work was to determine whether Rho-kinase-mediated calcium sensitisation contributes to contractions of the mouse anococcygeus smooth muscle and, if so, whether the process was activated by receptor-dependent or receptor-independent me
Publikováno v:
British Journal of Pharmacology. 136:1194-1200
The dartos is a thin sheet of smooth muscle closely associated with the skin of the scrotum. Although known to play an important role in scrotal thermoregulation, there has been no detailed study into the pharmacology, or thermosensitivity, of the da
Autor:
Alan Gibson, Ian McFadzean
Publikováno v:
British Journal of Pharmacology. 135:1-13
Contraction of smooth muscle is initiated, and to a lesser extent maintained, by a rise in the concentration of free calcium in the cell cytoplasm ([Ca(2+)](i)). This activator calcium can originate from two intimately linked sources--the extracellul
Publikováno v:
British Journal of Pharmacology. 132:807-814
1. The object of this study was to determine whether inhibition of capacitative calcium entry is essential for relaxation of the mouse anococcygeus via the NO/cyclic GMP signalling pathway. 2. In intact muscles, thapsigargin (Tg; 100 nM)-induced tone
Publikováno v:
European Journal of Pharmacology. 376:325-329
In mouse anococcygeus cells, simultaneous measurements of membrane currents and changes in intracellular Ca 2+ were obtained using “perforated-patch” whole-cell recordings and Fura-2 microfluorimetry. Carbachol (50 μM) and cyclopiazonic acid (10