Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Ian MacNeil"'
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Akademický článek
Gedatolisib shows superior potency and efficacy versus single-node PI3K/AKT/mTOR inhibitors in breast cancer models
Autor: Stefano Rossetti, Aaron Broege, Adrish Sen, Salmaan Khan, Ian MacNeil, Jhomary Molden, Ross Kopher, Stephen Schulz, Lance Laing
Publikováno v: npj Breast Cancer, Vol 10, Iss 1, Pp 1-15 (2024)
Abstract The PI3K, AKT, and mTOR (PAM) pathway is frequently dysregulated in breast cancer (BC) to accommodate high catabolic and anabolic activities driving tumor growth. Current therapeutic options for patients with hormone receptor (HR) + / HER2-
Externí odkaz: https://doaj.org/article/83461d834a3447219bcdc9cebd23fdba
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Abstract 4928: Gedatolisib, a well-tolerated pan-PI3K/mTOR inhibitor, exhibits potent therapeutic effects on endometrial cancer models regardless of their PI3K pathway mutational status
Autor: Stefano Rossetti, Aaron Broege, Ian MacNeil, Ben Rich, Jhomary Molden, Brian Sullivan, Lance Laing
Publikováno v: Cancer Research. 83:4928-4928
Background: The PI3K, AKT, and mTOR (PAM) pathway is one of the most commonly activated oncogenic pathways in gynecological cancers. Loss of PTEN function and PIK3CA activating mutations are especially frequent in endometrial cancer (EC). Targeting t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6da1a5cf6af0f2b81560f1f23337e930
https://doi.org/10.1158/1538-7445.am2023-4928
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3
Abstract 367: Sub-group of ovarian cancer patients with hyperactive RAS network signaling identified: Dynamic pathway activity test identifies patients that may benefit from PI3K/mTOR or PI3K/mTOR/BCL inhibitors
Autor: Stefano Rossetti, Aaron Broege, Joanna Sabat, Shu Wiley, Salmaan Khan, Catherine Kuzmicki, Ian MacNeil, Brian Sullivan, Lance Laing
Publikováno v: Cancer Research. 81:367-367
Background: Dysregulated RAS signaling through GPCRs is reported in ovarian cancer (OC), but no sub-groups of OC patients with actionable RAS genetic variants have been found. The complex mechanisms that link RAS nodes can trigger adaptation when a s
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::99090ff465a525bd87dc91e78c9f8441
https://doi.org/10.1158/1538-7445.am2021-367
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4
Genetically Modified Bacterial Strains and Novel Bacterial Artificial Chromosome Shuttle Vectors for Constructing Environmental Libraries and Detecting Heterologous Natural Products in Multiple Expression Hosts
Autor: Asuncion Martinez, Kara Brown, Ian Macneil, Marcia S. Osburne, Choi Lai Tiong Yip, Joern Hopke, Steven J. Kolvek
Publikováno v: Applied and Environmental Microbiology. 70:2452-2463
The enormous diversity of uncultured microorganisms in soil and other environments provides a potentially rich source of novel natural products, which is critically important for drug discovery efforts. Our investigators reported previously on the cr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87a219d53f5b54c86956b77eae542618
https://doi.org/10.1128/aem.70.4.2452-2463.2004
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A developmental switch in thymic lymphocyte maturation potential occurs at the level of hematopoietic stem cells
Autor: Ian MacNeil, Nobuko Uchida, Tatsuo Kina, Bruno Péault, Koichi Ikuta, Irving L. Weissman, Yueh-hsiu Chien
Publikováno v: Cell. 62:863-874
Hematopoietic stem cells (HSCs) isolated from mouse fetal liver, like adult HSCs, are Thy-1lo Lin- Sca-1+. Donor-derived V gamma 3+ T cells were detected in fetal thymic lobes repopulated in vitro with fetal liver HSCs, but not in those with adult bo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::884ebe2c18467a9cef1a2141439b1f38
https://doi.org/10.1016/0092-8674(90)90262-d
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7
Identification of a novel thymocyte growth-promoting factor derived from B cell lymphomas
Autor: Anne O'Garra, Takashi Suda, Albert Zlotnik, M Fischer, Ian MacNeil, Martha W. Bond
Publikováno v: Cellular Immunology. 129:228-240
We found a unique thymocyte growth-promoting activity in supernatants (SN) from subclones of the B cell lymphoma CH12.LX. We have tentatively named this activity B-TCGF (for B cell-derived T cell growth factor) and characterized the activity produced
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c80a1fa479859fdaed71a0e598f36fb1
https://doi.org/10.1016/0008-8749(90)90200-b
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8
Identification of a Novel Thymocyte Growth Factor Derived from B Cell Lymphomas
Autor: Takashi Suda, Albert Zlotnik, M Fischer, Ian MacNeil, Kevin W. Moore
Publikováno v: Mechanisms of Lymphocyte Activation and Immune Regulation III ISBN: 9781468459456
T cell ontogeny is a rapidly developing area. However, the signals that mediate the differentiation and growth of immature T cells in the thymus through different maturational stages remain largely unknown. While much has been accomplished in underst
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::016d3db22524ccf319844ab20d398a94
https://doi.org/10.1007/978-1-4684-5943-2_13
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