Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Ian M. Zitron"'
Publikováno v:
Cancer Biology & Therapy. 14:333-339
Expression and activity of indoleamine 2,3-dioxygenase (IDO), the first and rate-limiting step of the kynurenine pathway of tryptophan catabolism, can enable tumor cells to effectively evade the host's immune response. The potential role of this syst
Autor:
Majid Janabi, Csaba Juhász, Rouba Ali-Fehmi, Diane C. Chugani, Thomas J. Mangner, Pulak K. Chakraborty, Otto Muzik, Ian M Zitron, Zeina Nahleh, Sandeep Mittal, Sudeshna Bandyopadhyay
Publikováno v:
Nuclear Medicine and Biology. 39:926-932
Tryptophan oxidation via the kynurenine pathway is an important mechanism of tumoral immunoresistance. Increased tryptophan metabolism via the serotonin pathway has been linked to malignant progression in breast cancer. In this study, we combined qua
Autor:
Csaba Juhász, Sandeep Sood, William J. Kupsky, Otto Muzik, Sandeep Mittal, Bálint Alkonyi, Harry T. Chugani, Ian M Zitron, Diane C. Chugani
Publikováno v:
Journal of Neuro-Oncology. 107:365-372
Dysembryoplastic neuroepithelial tumors (DNTs) are typically hypometabolic but can show increased amino acid uptake on positron emission tomography (PET). To better understand mechanisms of amino acid accumulation in epileptogenic DNTs, we combined q
Autor:
Prahlad Parajuli, Amro Aboukameel, Fazlul H. Sarkar, Seema Sethi, Sandeep Mittal, Lisa Polin, Sharon K. Michelhaugh, Anthony R. Guastella, Kaushik Varadarajan, Aliccia Bollig-Fischer, Ian M Zitron, Neil V. Klinger, Salah A.D. Ebrahim, Aamir Ahmad, Sam Kiousis
Publikováno v:
Journal of Translational Medicine
Background There is a paucity of effective therapies for recurrent/aggressive meningiomas. Establishment of improved in vitro and in vivo meningioma models will facilitate development and testing of novel therapeutic approaches. Methods A primary men
Autor:
Mark Holodniy, John G. McHutchison, Frederick A. Anderson, Friesenhahn M, Krajden M, Ian M. Zitron, Robert G. Gish, Norah A. Terrault, Jean-Michel Pawlotsky, Robert P. Perrillo, Stuart C. Gordon
Publikováno v:
Journal of Viral Hepatitis. 12:465-472
Summary. Both absolute viral load and log decline in viral load from baseline were found clinically useful in predicting sustained virological response and lack of sustained virological response (non-sustained virological response, NSVR) to treatment
Autor:
Ian M. Zitron, Craig T. Hartrick
Publikováno v:
Journal of Neuropathic Pain & Symptom Palliation. 1:3-11
Many animal models of neuropathic pain involve both surgery and neural trauma. Chacur et al described the surgical placement of perisciatic gelfoam and a cannula through which zymosan was introduce...
Publikováno v:
Journal of the Neurological Sciences. 195:51-62
We have compared the induced expression of E-selectin in primary cultures of rat brain microvascular endothelial cells (EC), pericytes and in non-CNS microvascular endothelium stimulated with the cytokines, IL-1beta (20 ng/ml), and tumor necrosis fac
Publikováno v:
Viral Immunology. 13:521-531
We examined the proliferative responses of peripheral blood mononuclear cells obtained from 60 untreated patients who were seropositive by enzyme immunoassay, but negative for hepatitis C virus (HCV) RNA by reverse transcriptase-polymerase chain reac
Publikováno v:
Journal of Neuroscience Research. 46:438-444
We previously reported that recovery of Lewis rats from experimental autoimmune encephalomyelitis (EAE) is associated with the appearance of suppressor T cells (Ts). These Ts secrete TGF-beta which down-regulates the production of inflammatory cytoki
Autor:
Christopher H. Sherlock, Marc G. Ghany, Frank H. Anderson, Stuart C. Gordon, E. Jenny Heathcote, Robert P. Perrillo, David Hendricks, Lorraine Comanor, Ian M. Zitron
Publikováno v:
The American journal of gastroenterology. 96(10)
OBJECTIVE: In patients chronically infected with hepatitis C virus (HCV) undergoing antiviral therapy, sustained virologic response is suggested by viral clearance by end of treatment (EOT). Viral clearance is defined by nondetection of serum HCV RNA