Zobrazeno 1 - 10
of 86
pro vyhledávání: '"Ian M. Willis"'
Autor:
Gilles Willemin, François Mange, Viviane Praz, Séverine Lorrain, Pascal Cousin, Catherine Roger, Ian M. Willis, Nouria Hernandez
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
MAF1 is a nutrient-sensitive, TORC1-regulated repressor of RNA polymerase III (Pol III). MAF1 downregulation leads to increased lipogenesis in Drosophila melanogaster, Caenorhabditis elegans, and mice. However, Maf1−/− mice are lean as increased
Externí odkaz:
https://doaj.org/article/8ba802ba0e604010a78be43ab6e46906
Autor:
Karine Choquet, Maxime Pinard, Sharon Yang, Robyn D. Moir, Christian Poitras, Marie-Josée Dicaire, Nicolas Sgarioto, Roxanne Larivière, Claudia L. Kleinman, Ian M. Willis, Marie-Soleil Gauthier, Benoit Coulombe, Bernard Brais
Publikováno v:
Molecular Brain, Vol 12, Iss 1, Pp 1-10 (2019)
Abstract Recessive mutations in the ubiquitously expressed POLR3A and POLR3B genes are the most common cause of POLR3-related hypomyelinating leukodystrophy (POLR3-HLD), a rare childhood-onset disorder characterized by deficient cerebral myelin forma
Externí odkaz:
https://doaj.org/article/cbbd2c5dc7884b72a7840efca0d6b4f9
Autor:
Karine Choquet, Sharon Yang, Robyn D. Moir, Diane Forget, Roxanne Larivière, Annie Bouchard, Christian Poitras, Nicolas Sgarioto, Marie-Josée Dicaire, Forough Noohi, Timothy E. Kennedy, Joseph Rochford, Geneviève Bernard, Martin Teichmann, Benoit Coulombe, Ian M. Willis, Claudia L. Kleinman, Bernard Brais
Publikováno v:
Molecular Brain, Vol 10, Iss 1, Pp 1-13 (2017)
Abstract Recessive mutations in the ubiquitously expressed POLR3A gene cause one of the most frequent forms of childhood-onset hypomyelinating leukodystrophy (HLD): POLR3-HLD. POLR3A encodes the largest subunit of RNA Polymerase III (Pol III), which
Externí odkaz:
https://doaj.org/article/e9fa24610fa84790802d0015fd6a49cd
Autor:
Yunping Qiu, Robyn D. Moir, Ian M. Willis, Suresh Seethapathy, Robert C. Biniakewitz, Irwin J. Kurland
Publikováno v:
Metabolites, Vol 8, Iss 1, p 9 (2018)
Identifying non-annotated peaks may have a significant impact on the understanding of biological systems. In silico methodologies have focused on ESI LC/MS/MS for identifying non-annotated MS peaks. In this study, we employed in silico methodology to
Externí odkaz:
https://doaj.org/article/0cdbc2355c5c42c2aa3602b0a7bc86eb
Autor:
Ellen Phillips, Naseer Ahmad, Li Sun, James Iben, Christopher J Walkey, Aleksandra Rusin, Tony Yuen, Clifford J Rosen, Ian M Willis, Mone Zaidi, Deborah L Johnson
Publikováno v:
eLife, Vol 11 (2022)
MAF1, a key repressor of RNA polymerase (pol) III-mediated transcription, has been shown to promote mesoderm formation in vitro. Here, we show that MAF1 plays a critical role in regulating osteoblast differentiation and bone mass. Global deletion of
Externí odkaz:
https://doaj.org/article/21c7d77c7c1c4131ace5a7b64a9a61c7
Autor:
Ellen Phillips, Naseer Ahmad, Li Sun, James Iben, Christopher J Walkey, Aleksandra Rusin, Tony Yuen, Clifford J Rosen, Ian M Willis, Mone Zaidi, Deborah L Johnson
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2065e638fec5eabe3da6ed0846310839
https://doi.org/10.7554/elife.74740.sa2
https://doi.org/10.7554/elife.74740.sa2
Autor:
Robyn D. Moir, Catherine Moret, Gilles Willemin, Nouria Hernandez, François Mange, Ian M. Willis, Nicolas Bonhoure, Viviane Praz
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Scientific Reports
Scientific reports, vol. 10, no. 1, pp. 11956
Scientific Reports
Scientific reports, vol. 10, no. 1, pp. 11956
Maf1−/− mice are lean, obesity-resistant and metabolically inefficient. Their increased energy expenditure is thought to be driven by a futile RNA cycle that reprograms metabolism to meet an increased demand for nucleotides stemming from the dere
Autor:
Christoph W. Müller, Wim J. H. Hagen, Rene Wetzel, Robyn D. Moir, Matthias K. Vorländer, Florence Baudin, Ian M. Willis
Publikováno v:
Nature structural & molecular biology
Maf1 is a conserved inhibitor of RNA polymerase III (Pol III) that influences phenotypes ranging from metabolic efficiency to lifespan. Here, we present a 3.3-A-resolution cryo-EM structure of yeast Maf1 bound to Pol III, establishing that Maf1 seque
Autor:
Ellen Busschers, Christopher J. Walkey, Deborah L. Johnson, Naseer Ahmad, Clifford J. Rosen, Aleksandra Rusin, Li Sun, Mone Zaidi, James R. Iben, Tony Yuen, Ian M. Willis
Maf1, a key repressor of RNA polymerase III-mediated transcription, has been shown to promote mesoderm formation in vitro. Here, we show, for the first time, that Maf1 plays a critical role in the regulation of osteoblast differentiation and bone mas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d9fc538deec94750db36785f06adc10
https://doi.org/10.1101/2021.11.09.467887
https://doi.org/10.1101/2021.11.09.467887
Autor:
Claudia L. Kleinman, Bernard Brais, Marie Josée Dicaire, Maxime Pinard, Marie-Soleil Gauthier, Roxanne Larivière, Christian Poitras, Karine Choquet, Nicolas Sgarioto, Sharon Yang, Ian M. Willis, Benoit Coulombe, Robyn D. Moir
Publikováno v:
Molecular Brain, Vol 12, Iss 1, Pp 1-10 (2019)
Molecular Brain
Molecular Brain
Recessive mutations in the ubiquitously expressed POLR3A and POLR3B genes are the most common cause of POLR3-related hypomyelinating leukodystrophy (POLR3-HLD), a rare childhood-onset disorder characterized by deficient cerebral myelin formation and