Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Ian M. Thornell"'
Autor:
Gopinathan Gangadharan Nambiar, Sussette Gonzalez Szachowicz, Christian F. Zirbes, Jared J. Hill, Linda S. Powers, David K. Meyerholz, Ian M. Thornell, David A. Stoltz, Anthony J. Fischer
Publikováno v:
Frontiers in Pediatrics, Vol 12 (2024)
IntroductionMeconium ileus (MI) is a life-threatening obstruction of the intestines affecting ∼15% of newborns with cystic fibrosis (CF). Current medical treatments for MI often fail, requiring surgical intervention. MI typically occurs in newborns
Externí odkaz:
https://doaj.org/article/1b4483c0066844d2a9383238af8cf27f
Autor:
Lei Lei, Soumba Traore, Guillermo S. Romano Ibarra, Philip H. Karp, Tayyab Rehman, David K. Meyerholz, Joseph Zabner, David A. Stoltz, Patrick L. Sinn, Michael J. Welsh, Paul B. McCray Jr., Ian M. Thornell
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 20 (2023)
The volume and composition of a thin layer of liquid covering the airway surface defend the lung from inhaled pathogens and debris. Airway epithelia secrete Cl– into the airway surface liquid through cystic fibrosis transmembrane conductance regula
Externí odkaz:
https://doaj.org/article/2cd2777105f44a3382766c3e36dc6f28
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Fluid and anion secretion are important functions of the biliary tract. It has been established that cAMP regulates Na+ absorption through NHE3. However, mechanisms of gallbladder anion transport are less defined. We created organoids and organoid-de
Externí odkaz:
https://doaj.org/article/241555d1cf11473fb339500de68bcf04
Autor:
Emma M. Stapleton, Kathy Keck, Robert Windisch, Mallory R. Stroik, Andrew L. Thurman, Joseph Zabner, Ian M. Thornell, Alejandro A. Pezzulo, Julia Klesney-Tait, Alejandro P. Comellas
Publikováno v:
PLoS ONE, Vol 17, Iss 6 (2022)
Introduction Vitamin D supplementation has been suggested to enhance immunity during respiratory infection season. We tested the effect of active vitamin D (calcitriol) supplementation on key airway innate immune mechanisms in vitro. Methods Primary
Externí odkaz:
https://doaj.org/article/6c57798ee15147c9ab9896bdd54c7823
Publikováno v:
Physiological Reports, Vol 8, Iss 19, Pp n/a-n/a (2020)
Abstract Introduction One method for assessing the in vitro response to CFTR‐modulating compounds is by analysis of epithelial monolayers in an Ussing chamber, where the apical and basolateral surfaces are isolated and the potential difference, sho
Externí odkaz:
https://doaj.org/article/cbecdc03fbdc48c6b66e43318d5afcf5
Autor:
Ian M. Thornell, Mark Oliver Bevensee
Publikováno v:
Frontiers in Physiology, Vol 6 (2015)
The Slc4 family of transporters is comprised of anion exchangers (AE1-4), Na-coupled bicarbonate transporters (NCBTs) including electrogenic Na/bicarbonate cotransporters (NBCe1 and NBCe2), electroneutral Na/bicarbonate cotransporters (NBCn1 and NBCn
Externí odkaz:
https://doaj.org/article/11a1002bba2a4b7886b415691bc2d33a
Autor:
Camilo Cano Portillo, Raul Villacreses, Andrew L. Thurman, Alejandro A. Pezzulo, Joseph Zabner, Ian M. Thornell
Publikováno v:
American Journal of Physiology-Cell Physiology. 323:C1044-C1051
Na/K ATPase activity is essential for ion transport across epithelia. FXYD3, a γ subunit of the Na/K ATPase, is expressed in the airway, but its function remains undetermined. Single-cell RNA sequencing and immunohistochemistry revealed that FXYD3 l
Autor:
Andrew L. Thurman, Xiaopeng Li, Raul Villacreses, Wenjie Yu, Huiyu Gong, Steven E. Mather, Guillermo S. Romano-Ibarra, David K. Meyerholz, David A. Stoltz, Michael J. Welsh, Ian M. Thornell, Joseph Zabner, Alejandro A. Pezzulo
Publikováno v:
American journal of respiratory cell and molecular biology. 66(6)
Lack of CFTR (cystic fibrosis transmembrane conductance regulator) affects the transcriptome, composition, and function of large and small airway epithelia in people with advanced cystic fibrosis (CF); however, whether lack of CFTR causes cell-intrin
Autor:
Annie Ehler, Xiaopeng Li, Raul Villacreses, David K. Meyerholz, Steven E Mather, Adam Zabner, Joseph Zabner, David A. Stoltz, Christian M Brommel, Ian M. Thornell, Lin Lu, Julio Noriega
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 65:146-156
In a newborn pig cystic fibrosis (CF) model, the ability of gland-containing airways to fight infection was affected by at least two major host-defense defects: impaired mucociliary transport and a...
Autor:
Camilo Cano Portillo, Raul Villacreses, Andrew Thurman, Alejandro Pezzulo, Joseph Zabner, Ian M. Thornell
Publikováno v:
The FASEB Journal. 36