Výsledky vyhledávání - "Ian M. Soderling"

Potentiation of Sulfonylurea Action by an EPAC-selective cAMP Analog in INS-1 Cells: Comparison of Tolbutamide and Gliclazide and a Potential Role for EPAC Activation of a 2-APB-sensitive Ca2+Influx

Autor: Marcy L. Guerra, Ian M. Soderling, Gregory H. Hockerman, Allison M. Lange, Yuchen Wang, Amy E. Salyer, Hilary J. Broderick, Evan P.S. Pratt, Rachel E. Jarrard

Publikováno v: Molecular Pharmacology. 83:191-205

Tolbutamide and gliclazide block the K(ATP) channel K(ir)6.2/Sur1, causing membrane depolarization and stimulating insulin secretion in pancreatic beta cells. We examined the ability of the EPAC-selective cAMP analog 8-pCPT-2'-O-Me-cAMP-AM to potenti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::576501f9fb161c362ab24e4e70cfecbb
https://doi.org/10.1124/mol.112.081943

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Uncoupling of Cav1.2 from Ca(2+)-induced Ca(2+) release and SK channel regulation in pancreatic β-cells

Autor: Rachel E. Jarrard, Allison M. Lange, Amy E. Salyer, Evan P.S. Pratt, Gregory H. Hockerman, Ian M. Soderling, Yuchen Wang, Marcy L. Guerra

Publikováno v: Molecular endocrinology (Baltimore, Md.). 28(4)

We investigated the role of Cav1.2 in pancreatic β-cell function by expressing a Cav1.2 II-III loop/green fluorescent protein fusion in INS-1 cells (Cav1.2/II-III cells) to disrupt channel-protein interactions. Neither block of KATP channels nor sti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c67de4cc71520b226d60cbf1988b44e
https://pubmed.ncbi.nlm.nih.gov/24506535

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