Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Ian M. Smyth"'
Autor:
Ming Shen Tham, Denny L. Cottle, Allara K. Zylberberg, Kieran M. Short, Lynelle K. Jones, Perkin Chan, Sarah E. Conduit, Jennifer M. Dyson, Christina A. Mitchell, Ian M. Smyth
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Aurora Kinase A (AURKA) promotes cell proliferation and is overexpressed in different types of polycystic kidney disease (PKD). To understand AURKA’s role in regulating renal cyst development we conditionally deleted the gene in mouse mode
Externí odkaz:
https://doaj.org/article/226bfb45e8934ee1ba253ad4552b6197
Autor:
Warwick J. Teague, Matthew L. M. Jones, Leanne Hawkey, Ian M. Smyth, Angelique Catubig, Sebastian K. King, Gulcan Sarila, Ruili Li, John M. Hutson
Publikováno v:
Frontiers in Genetics, Vol 9 (2018)
Background: Duodenal atresia (DA) is a congenital obstruction of the duodenum, which affects 1 in 7000 pregnancies and requires major surgery in the 1st days of life. Three morphological DA types are described. In humans, the association between DA a
Externí odkaz:
https://doaj.org/article/e30620c0d6a34e158e380be9e7b5ef13
Autor:
Stephanie Grabow, Andrew J. Kueh, Francine Ke, Hannah K. Vanyai, Bilal N. Sheikh, Michael A. Dengler, William Chiang, Samantha Eccles, Ian M. Smyth, Lynelle K. Jones, Frederic J. de Sauvage, Mark Scott, Lachlan Whitehead, Anne K. Voss, Andreas Strasser
Publikováno v:
Cell Reports, Vol 24, Iss 12, Pp 3285-3295.e4 (2018)
Summary: Apoptotic cell death removes unwanted cells and is regulated by interactions between pro-survival and pro-apoptotic members of the BCL-2 protein family. The regulation of apoptosis is thought to be crucial for normal embryonic development. A
Externí odkaz:
https://doaj.org/article/b958c8def9dc4e4eb7387f18421e59a4
Autor:
Holly K. Voges, Simon R. Foster, Liam Reynolds, Benjamin L. Parker, Lynn Devilée, Gregory A. Quaife-Ryan, Patrick R.J. Fortuna, Ellen Mathieson, Rebecca Fitzsimmons, Mary Lor, Christopher Batho, Janice Reid, Mark Pocock, Clayton E. Friedman, Dalia Mizikovsky, Mathias Francois, Nathan J. Palpant, Elise J. Needham, Marina Peralta, Gonzalo del Monte-Nieto, Lynelle K. Jones, Ian M. Smyth, Neda R. Mehdiabadi, Francesca Bolk, Vaibhao Janbandhu, Ernestene Yao, Richard P. Harvey, James J.H. Chong, David A. Elliott, Edouard G. Stanley, Sophie Wiszniak, Quenten Schwarz, David E. James, Richard J. Mills, Enzo R. Porrello, James E. Hudson
Refereed/Peer-reviewed Crosstalk between cardiac cells is critical for heart performance. Here we show that vascular cells within human cardiac organoids (hCOs) enhance their maturation, force of contraction, and utility in disease modeling. Herein w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8998951ca54fee675a01326833731eca
https://hdl.handle.net/11541.2/34444
https://hdl.handle.net/11541.2/34444
Branching morphogenesis in the developing kidney is not impacted by nephron formation or integration
Autor:
Kieran M Short, Alexander N Combes, Valerie Lisnyak, James G Lefevre, Lynelle K Jones, Melissa H Little, Nicholas A Hamilton, Ian M Smyth
Publikováno v:
eLife, Vol 7 (2018)
Branching morphogenesis of the ureteric bud is integral to kidney development; establishing the collecting ducts of the adult organ and driving organ expansion via peripheral interactions with nephron progenitor cells. A recent study suggested that t
Externí odkaz:
https://doaj.org/article/e5499d4ad0ec4ecdbe4e140fc7cea1df
Autor:
Ian M. Smyth
Publikováno v:
J Am Soc Nephrol
BACKGROUND: Most nephrons are added in late gestation. Truncated extrauterine nephrogenesis in premature infants results in fewer nephrons and significantly increased risk for CKD in adulthood. To overcome the ethical and technical difficulties assoc
Publikováno v:
Dev Biol
Adamts18 encodes a secreted metalloprotease restricted to branch-tip progenitor pools directing the morphogenesis of multiple mammalian organs. Adamts18 was targeted to explore a potential role in branching morphogenesis. In the kidney, an arborized
Autor:
Tia DiTommaso, Lynelle K Jones, Denny L Cottle, WTSI Mouse Genetics Program, Anna-Karin Gerdin, Valerie E Vancollie, Fiona M Watt, Ramiro Ramirez-Solis, Allan Bradley, Karen P Steel, John P Sundberg, Jacqueline K White, Ian M Smyth
Publikováno v:
PLoS Genetics, Vol 10, Iss 10, p e1004705 (2014)
The skin is a highly regenerative organ which plays critical roles in protecting the body and sensing its environment. Consequently, morbidity and mortality associated with skin defects represent a significant health issue. To identify genes importan
Externí odkaz:
https://doaj.org/article/03c745db72054c98b2c15844f603b5cc
Autor:
Tia DiTommaso, Denny L Cottle, Helen B Pearson, Holger Schlüter, Pritinder Kaur, Patrick O Humbert, Ian M Smyth
Publikováno v:
PLoS Genetics, Vol 10, Iss 10, p e1004706 (2014)
Keratins are cytoskeletal intermediate filament proteins that are increasingly being recognised for their diverse cellular functions. Here we report the consequences of germ line inactivation of Keratin 76 (Krt76) in mice. Homozygous disruption of th
Externí odkaz:
https://doaj.org/article/8f10fdad58e248f49215c890e550eb36
Autor:
Ian M, Smyth
Publikováno v:
Current topics in developmental biology. 143
The kidney plays an integral role in filtering the blood-removing metabolic by-products from the body and regulating blood pressure. This requires the establishment of large numbers of efficient and specialized blood filtering units (nephrons) that i