Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Ian M. Sealy"'
Autor:
Vincenzo Torraca, Richard J. White, Ian M. Sealy, Maria Mazon-Moya, Gina Duggan, Alexandra R. Willis, Elisabeth M. Busch-Nentwich, Serge Mostowy
Publikováno v:
Disease Models & Mechanisms, Vol 17, Iss 1 (2024)
Externí odkaz:
https://doaj.org/article/8c1b711738714e84b10742da837b49e8
Autor:
Karin Tuschl, Richard J. White, Chintan Trivedi, Leonardo E. Valdivia, Stephanie Niklaus, Isaac H. Bianco, Chris Dadswell, Ramón González-Méndez, Ian M. Sealy, Stephan C. F. Neuhauss, Corinne Houart, Jason Rihel, Stephen W. Wilson, Elisabeth M. Busch-Nentwich
Publikováno v:
Disease Models & Mechanisms, Vol 15, Iss 6 (2022)
Manganese neurotoxicity is a hallmark of hypermanganesemia with dystonia 2, an inherited manganese transporter defect caused by mutations in SLC39A14. To identify novel potential targets of manganese neurotoxicity, we performed transcriptome analysis
Externí odkaz:
https://doaj.org/article/f65f7e53350a476f8c1a355ab69555a3
Autor:
Aleksandra M. Mech, Munise Merteroglu, Ian M. Sealy, Muy-Teck Teh, Richard J. White, William Havelange, Caroline H. Brennan, Elisabeth M. Busch-Nentwich
Publikováno v:
Frontiers in Psychiatry, Vol 12 (2022)
Developmental consequences of prenatal drug exposure have been reported in many human cohorts and animal studies. The long-lasting impact on the offspring—including motor and cognitive impairments, cranial and cardiac anomalies and increased preval
Externí odkaz:
https://doaj.org/article/1c79756316f54b768f577a180fee39ff
Autor:
John E. Collins, Richard J. White, Nicole Staudt, Ian M. Sealy, Ian Packham, Neha Wali, Catherine Tudor, Cecilia Mazzeo, Angela Green, Emma Siragher, Edward Ryder, Jacqueline K. White, Irene Papatheodoru, Amy Tang, Anja Füllgrabe, Konstantinos Billis, Stefan H. Geyer, Wolfgang J. Weninger, Antonella Galli, Myriam Hemberger, Derek L. Stemple, Elizabeth Robertson, James C. Smith, Timothy Mohun, David J. Adams, Elisabeth M. Busch-Nentwich
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
The transcriptional signature of embryonic lethality has not been defined. Here, the authors, as part of the Deciphering the Mechanisms of Developmental Disorders programme, define genes causing murine embryonic lethality around E9.5 and identify dev
Externí odkaz:
https://doaj.org/article/0cb4c8c4995e4b478eecfb999695d344
Autor:
Catherine M. Scahill, Zsofia Digby, Ian M. Sealy, Richard J. White, Neha Wali, John E. Collins, Derek L. Stemple, Elisabeth M. Busch-Nentwich
Publikováno v:
Wellcome Open Research, Vol 2 (2018)
Background: Mutations in proteins involved in telomere maintenance lead to a range of human diseases, including dyskeratosis congenita, idiopathic pulmonary fibrosis and cancer. Telomerase functions to add telomeric repeats back onto the ends of chro
Externí odkaz:
https://doaj.org/article/7549ca017f244f3089066073b1bfff71
Autor:
Vincenzo Torraca, Richard J. White, Ian M. Sealy, Maria Mazon-Moya, Gina Duggan, Alexandra Willis, Elisabeth M. Busch-Nentwich, Serge Mostowy
Shigella flexneri is a human adapted pathovar of Escherichia coli that can invade the intestinal epithelium, causing inflammation and bacillary dysentery. Although an important human pathogen, the host response to S. flexneri is poorly understood. Ze
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd856366dd170a8f28d44d17f6f47d3f
https://doi.org/10.1101/2022.10.03.510593
https://doi.org/10.1101/2022.10.03.510593
Autor:
Eva Sheardown, Aleksandra M. Mech, Maria Elena Miletto Petrazzini, Adele Leggieri, Agnieszka Gidziela, Saeedeh Hosseinian, Ian M. Sealy, Jose V. Torres-Perez, Elisabeth M. Busch-Nentwich, Margherita Malanchini, Caroline H. Brennan
Publikováno v:
Neurosci Biobehav Rev
Psychiatric disorders represent a significant burden in our societies. Despite the convincing evidence pointing at gene and gene-environment interaction contributions, the role of genetics in the aetiology of psychiatric disease is still poorly under
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76f29439c061d4cbfc8440ffdd823d52
https://europepmc.org/articles/PMC9016269/
https://europepmc.org/articles/PMC9016269/
Autor:
Karin Tuschl, Richard J. White, Chintan Trivedi, Leonardo E. Valdivia, Stephanie Niklaus, Isaac H. Bianco, Chris Dadswell, Ramón González-Méndez, Ian M. Sealy, Stephan C. F. Neuhauss, Corinne Houart, Jason Rihel, Stephen W. Wilson, Elisabeth M. Busch-Nentwich
Publikováno v:
Disease modelsmechanisms. 15(6)
Manganese neurotoxicity is a hallmark of hypermanganesemia with dystonia 2, an inherited manganese transporter defect caused by mutations in SLC39A14. To identify novel potential targets of manganese neurotoxicity, we performed transcriptome analysis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bd24a98fd0dca92f6ab8e8e1169bd8b
https://pubmed.ncbi.nlm.nih.gov/35514229
https://pubmed.ncbi.nlm.nih.gov/35514229
Autor:
Stephen W. Wilson, Elisabeth M. Busch-Nentwich, Corinne Houart, Karin Tuschl, Isaac H. Bianco, Stephan C.F. Neuhauss, Richard White, Leonardo E Valdivia, Stephanie Niklaus, Ian M Sealy
Mutations in SLC39A14, a manganese uptake transporter, lead to a neurodegenerative disorder characterised by accumulation of manganese in the brain and rapidly progressive dystonia-parkinsonism (Hypermanganesemia with Dystonia 2, HMNDYT2). Similar to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25c9d692c5fd46662de009e6fc4f1ce6
Autor:
Emma Siragher, Anja Füllgrabe, Edward Ryder, Elisabeth M. Busch-Nentwich, James C. Smith, Wolfgang Weninger, Irene Papatheodoru, Neha Wali, Angela Green, Antonella Galli, Jacqueline K. White, Elizabeth J. Robertson, Myriam Hemberger, Amy Tang, David J. Adams, Stefan H. Geyer, Konstantinos Billis, Richard J. White, John E. Collins, Timothy J. Mohun, Nicole Staudt, Derek L. Stemple, Ian M Sealy, Cecilia Icoresi Mazzeo, Catherine Tudor, Ian Packham
Publikováno v:
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
The Deciphering the Mechanisms of Developmental Disorders programme has analysed the morphological and molecular phenotypes of embryonic and perinatal lethal mouse mutant lines in order to investigate the causes of embryonic lethality. Here we show t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23906ad74e1c64e4484b93c599691342
https://doi.org/10.1038/s41467-019-10642-x
https://doi.org/10.1038/s41467-019-10642-x