Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Ian M. Mawer"'
Autor:
George R. Marshall, Michael Rowley, Sarah Grimwood, Paul D. Leeson, Mark Peter Ridgill, Neil Roy Curtis, Janusz Jozef Kulagowski, Ian M. Mawer
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:1145-1150
A series of analogues of the novel diiodotyrosine derived NMDA glycine-site ligand (R)-4 was prepared in which the aryl substitution, chain length and amino acid groups were varied. The key structural features for binding are the α-amino acid functi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:2643-2648
Tetramic acids ( 9 ) have been designed as novel glycine site N-methyl-D-aspartate receptor antagonists.
Autor:
Robert W. Carling, Ian M. Mawer, Mark Peter Ridgill, John A. Kemp, Graeme Irvine Stevenson, Raymond Baker, Alan C. Foster, Michael Rowley, Paul D. Leeson, Janusz Jozef Kulagowski, Ian Stansfield, Julian D. Smith
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 3:299-304
3-Substituted-2-quinoloners ( 6–8 ) have been identified as glycine-site N-methyl-D-aspartate receptor antagonists. It is proposed that the α-phenyl lactam unit in the potent 4-hydroxy-3-phenyl derivatives ( 7d and 8b , L-701,315) may act as a gly
Autor:
Ian M. Mawer, Janusz Jozef Kulagowski, George R. Marshall, Mark Peter Ridgill, Paul D. Leeson, Michael Rowley, Neil Roy Curtis, Sarah Grimwood
Publikováno v:
ChemInform. 27
Autor:
Neil Roy Curtis, G.P. Cook, Smita Patel, Linda J. Bristow, Ian M. Mawer, Janusz Jozef Kulagowski
Publikováno v:
Neuropharmacology. 37(6)
The putative D3 receptor agonist, (+)-PD 128907, is widely used to study the functional relevance of D3 receptors in vivo. Given that non-selective D2/3/4 receptor agonists serve as effective discriminative stimuli in rats we have trained animals to
Autor:
Janusz J. Kulagowski, Howard B. Broughton, Neil R. Curtis, Ian M. Mawer, Mark P. Ridgill, Raymond Baker, Frances Emms, Stephen B. Freedman, Rosemarie Marwood, Shil Patel, Smita Patel, C. Ian Ragan, Paul D. Leeson
Publikováno v:
Journal of medicinal chemistry. 39(10)
Autor:
Paul D. Leeson, Ian M. Mawer, Janusz Jozef Kulagowski, Alan C. Foster, Sarah Grimwood, Michael Rowley
Publikováno v:
European journal of pharmacology. 290(3)
Using radioligand binding studies, we have investigated the binding properties of four 4-hydroxy-2-quinolones, a novel series of selective antagonists for the glycine site on the N-methyl-D-aspartate (NMDA) receptor. L-701,324, L-703,717, L-698,532 a
Autor:
Ian Stansfield, A M Moseley, Ian M. Mawer, N. R. Curtis, R. Baker, Michael Rowley, Paul D. Leeson, Alan C. Foster, Janusz Jozef Kulagowski, M. P. Ridgill
Publikováno v:
Journal of medicinal chemistry. 37(10)
Autor:
Christopher Moyes, T Chan, R. Baker, Robert W. Carling, Ian M. Mawer, Steve Thomas, Alan C. Foster, Paul D. Leeson, Julian D. Smith, K W Moore
Publikováno v:
Journal of medicinal chemistry. 36(22)
3,4-Dihydro-2(1H)-quinolones, evolved from 2-carboxy-1,2,3,4,- tetrahydroquinolines and 3-carboxy-4-hydroxy-2(1H)-quinolones, have been synthesized and evaluated in vitro for antagonist activity at the glycine site on the NMDA receptor and for AMPA [
Autor:
Joseph P. Vacca, S. Jane de Solms, Steven D. Young, Joel R. Huff, David C. Billington, Raymond Baker, Janusz J. Kulagowski, Ian M. Mawer
Publikováno v:
ACS Symposium Series ISBN: 9780841220867
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b52acf965cfdd48d174c2a33140c0c4
https://doi.org/10.1021/bk-1991-0463.ch005
https://doi.org/10.1021/bk-1991-0463.ch005