Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Ian M. Levitan"'
Publikováno v:
iScience, Vol 26, Iss 7, Pp 107178- (2023)
Summary: Protein kinase C (PKC) isoforms regulate many important signaling pathways. Here, we report that PKC activation by phorbol 12-myristate 13-acetate (PMA) enhanced A2B adenosine receptor (AR)-mediated, but not β2-adrenergic receptor-mediated,
Externí odkaz:
https://doaj.org/article/126eeafbe008438ba5fb2a678efb27ec
Autor:
Peter A. Kropp, Philippa Rogers, Sydney E. Kelly, Rebecca McWhirter, Willow D. Goff, Ian M. Levitan, David M. Miller, Andy Golden
Publikováno v:
Disease Models & Mechanisms, Vol 16, Iss 2 (2023)
Externí odkaz:
https://doaj.org/article/7fad760d19074a22ad90ec75e984d5ed
Autor:
Claudia Lee, Jeffrey S. Smith, Dean P. Staus, Sudarshan Rajagopal, Thomas F. Pack, Issac Choi, Xinyu Xiong, Zhiyuan Ma, Dylan Eiger, Ian M. Levitan, Gayathri Viswanathan, Alem W. Kahsai, Kevin Zheng, Joshua C. Snyder, Marc G. Caron, Anmol Warman, Asuka Inoue, Lauren K. Rochelle
Publikováno v:
Science. 371
Another way for GPCRs to signal G protein–coupled receptors (GPCRs) normally transmit signals by coupling to heterotrimeric guanine nucleotide–binding proteins (G proteins) or by binding β-arrestin proteins. Smith et al. provide evidence for ano
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::44854b6d99141f5ba0b875f6d96fb686
https://doi.org/10.1126/science.aay1833
https://doi.org/10.1126/science.aay1833
Autor:
Jeffrey S, Smith, Thomas F, Pack, Asuka, Inoue, Claudia, Lee, Kevin, Zheng, Issac, Choi, Dylan S, Eiger, Anmol, Warman, Xinyu, Xiong, Zhiyuan, Ma, Gayathri, Viswanathan, Ian M, Levitan, Lauren K, Rochelle, Dean P, Staus, Joshua C, Snyder, Alem W, Kahsai, Marc G, Caron, Sudarshan, Rajagopal
Publikováno v:
Science
Heterotrimeric guanine nucleotide–binding protein (G protein)–coupled receptors (GPCRs) are common drug targets and canonically couple to specific G(α) protein subtypes and β-arrestin adaptor proteins. G protein–mediated signaling and β-arre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::552b9143d0c14e52fa4fab72709435fd
https://pubmed.ncbi.nlm.nih.gov/33479120
https://pubmed.ncbi.nlm.nih.gov/33479120
Autor:
Asuka Inoue, Ian M. Levitan, Jeffrey S. Smith, Issac Choi, Alem W. Kahsai, Joshua C. Snyder, Xinyu Xiong, Zhiyuan Ma, Claudia Lee, Sudarshan Rajagopal, Marc G. Caron, Kevin Zheng, Dean P. Staus, Thomas F. Pack, Lauren K. Rochelle
SummaryG-protein-coupled receptors (GPCRs) enable cells to sense and respond appropriately to hormonal and environmental signals, and are a target of ~30% of all FDA-approved medications. Canonically, each GPCR couples to distinct Gαproteins, such a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dbaa4573232e963d44e509f925439cc
