Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Ian M. Holdaway"'
Publikováno v:
Orthopaedics & Traumatology: Surgery & Research. 109:103136
Background Three-dimensional printing of implants allows the ability to produce implants and interfaces which theoretically better mimic “normal” bone behaviour, leading to a possible reduction in stress shielding thus maintaining bone mineral de
Autor:
Ian M. Holdaway, Rajesh V. Thakker, J. P. Fryns, H Van Esch, W.J.M. Van de Ven, Brian Harding, Peter M.A. Groenen, Koenraad Devriendt, Gert Vanderlinden, Peter Lichtner, Rolf Beetz, Nick Shaw, M A Nesbit, Simone Schuffenhauer, Rudolf W. Bilous
Terminal deletions of chromosome 10p result in a DiGeorge-like phenotype that includes hypoparathyroidism, heart defects, immune deficiency, deafness and renal malformations. Studies in patients with 10p deletions have defined two non-overlapping reg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f9a45383c0875478158c2cb570ddfbd
https://ora.ox.ac.uk/objects/uuid:e561af0a-55ae-4b61-a313-f961edb1b50f
https://ora.ox.ac.uk/objects/uuid:e561af0a-55ae-4b61-a313-f961edb1b50f
Autor:
Ian M. Holdaway, Paul M. Stewart, Mark J Bolland, Olaf M. Dekkers, Raoul C. Reulen, Richard N. Clayton, Zaki Hassan-Smith, Alberto M. Pereira, Georgia Ntali, Niki Karavitaki, Jorgen Lindholm, Peter W. Jones
Publikováno v:
Lancet Diabetes and Endocrinology, 4(7), 569-576. ELSEVIER SCIENCE INC
Clayton, R N, Jones, P W, Reulen, R C, Stewart, P M, Hassan-Smith, Z K, Ntali, G, Karavitaki, N, Dekkers, O M, Pereira, A M, Bolland, M, Holdaway, I & Lindholm, J 2016, ' Mortality in patients with Cushing's disease more than 10 years after remission : a multicentre, multinational, retrospective cohort study ', The Lancet Diabetes & Endocrinology, vol. 4, no. 7, pp. 569-576 . https://doi.org/10.1016/S2213-8587(16)30005-5
Clayton, R N, Jones, P W, Reulen, R C, Stewart, P M, Hassan-Smith, Z K, Ntali, G, Karavitaki, N, Dekkers, O M, Pereira, A M, Bolland, M, Holdaway, I & Lindholm, J 2016, ' Mortality in patients with Cushing's disease more than 10 years after remission : a multicentre, multinational, retrospective cohort study ', The Lancet Diabetes & Endocrinology, vol. 4, no. 7, pp. 569-576 . https://doi.org/10.1016/S2213-8587(16)30005-5
BACKGROUND: No agreement has been reached on the long-term survival prospects for patients with Cushing's disease. We studied life expectancy in patients who had received curative treatment and whose hypercortisolism remained in remission for more th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb699963b104b6b0b6f42f65be059994
http://hdl.handle.net/1887/99352
http://hdl.handle.net/1887/99352
Publikováno v:
Clinical Endocrinology. 77:575-578
SummaryObjective Preclinical studies demonstrate that thiazolidinediones (TZDs) decrease growth hormone (GH) and insulin-like growth factor-1 (IGF-1) levels, suggesting that they might be effective treatments for acromegaly. This study investigated t
Autor:
Juliet Jennings, Fergus J. Cameron, Ian M. Holdaway, Albert Beckers, Lauri A. Aaltonen, Auli Karhu, Adrian Daly, Maria A. Tichomirowa, Marianthi Georgitsi
Publikováno v:
European Journal of Endocrinology. 161:799-804
ObjectiveMutations in the aryl hydrocarbon receptor-interacting protein (AIP) were recently shown to confer a pituitary adenoma predisposition in patients with familial isolated pituitary adenomas (FIPA). We report a large Samoan FIPA kindred from Au
Autor:
Maria Nesterova, Edward H. Oldfield, Ying Wang, Isaac Levy, Fabio R. Faucz, Daniel J. Bernard, Maya Lodish, Rodrigo Bertollo de Alexandre, Paraskevi Xekouki, Ian M. Holdaway, Beata Bak, Nienke R. Biermasz, Jan M. Wit, Emmanouil Saloustros, Monalisa F. Azevedo, Prashant Chittiboina, Anelia Horvath, Paul L. Hofman, Allison D. Manning, Eva Szarek, Evgenia Gourgari, Yvonne C Anderson, Constantine A. Stratakis, Giampaolo Trivellin
Publikováno v:
Endocrine-Related Cancer, 22(1), 47-54
IGSF1 is a membrane glycoprotein highly expressed in the anterior pituitary. Pathogenic mutations in theIGSF1gene (on Xq26.2) are associated with X-linked central hypothyroidism and testicular enlargement in males. In this study, we tested the hypoth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46667bec6245b46b03152433c2dc33f5
https://doi.org/10.1530/erc-14-0465
https://doi.org/10.1530/erc-14-0465
Autor:
Patrick J. Manning, S. Metcalfe, P. Moodie, D. Staples-Moon, Ian M. Holdaway, Wayne S. Cutfield, Penny J. Hunt, Greg D. Gamble, N. Ninow
Publikováno v:
Clinical endocrinology. 83(1)
SummaryObjective Treatment of growth hormone (GH)-deficient adults with GH has been shown to improve a range of metabolic abnormalities and enhance quality of life. However, the results of access to nationally funded treatment have not been reported.
Autor:
Angus Dobbie, S.P.A. Rigden, Carol A. Crowe, Ian M. Holdaway, Asif Ali, Rajesh V. Thakker, Michael A. Levine, Brian Harding, Julian R. Sampson, Robert R. McWilliams, Andrew J Williams, Michael R. Bowl, Geeta Hampson, M. Andrew Nesbit, Alejandro Ayala
Publikováno v:
Europe PubMed Central
The hypoparathyroidism, deafness, and renal dysplasia (HDR) syndrome is an autosomal dominant disorder caused by mutations of the dual zinc finger transcription factor, GATA3. The C-terminal zinc finger (ZnF2) binds DNA, whereas the N-terminal finger
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 89:667-674
Studies of acromegaly have shown a doubling of mortality compared with the general population. With the development of new modalities of treatment, it has become important to identify prognostic factors relating to mortality. Between 1964 and 2000, 2
Autor:
V J Harvey, Anne Lethaby, Vijay Singh, Paul Thompson, Barbara H. Mason, Ian M. Holdaway, Barrie D. Evans
Publikováno v:
ANZ Journal of Surgery. 73:905-908
Background: Insulin-like growth factor-I (IGF-I) and IGF binding protein-3 (IGFBP-3) appear to influence the growth of breast cancer cells in vitro, and epidemiological studies suggest higher serum IGF-I levels increase the risk of breast cancer. IGF