Výsledky vyhledávání - "Ian M. Heger"

Increased Intracranial Pressure Damages Optic Nerve Structural Support

Autor: Ian M. Heger, Zulqar Islam, Maegan Newell, Ann Marie Kuchinski, Tyler Hockman, Robert W. Gibson, Lauren East, Matthew Lyon, Hongyan Xu, Parth Agrawal

Publikováno v: Journal of Neurotrauma. 36:3132-3137

Optic nerve sheath diameter (ONSD) is used clinically as a noninvasive measure for elevated intracranial pressure (ICP). This study had two purposes: to investigate the immediate effects optic nerve sheath (ONS) dilation post-ICP increase on trabecul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dee321c3e9f7a474ac8a46c8f5e3da63
https://doi.org/10.1089/neu.2019.6490

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Pediatric occipital condyle morphometric analysis using computed tomography with evaluation for occipital condyle screw placement

Autor: Perounsack X. Moon, Angela Viers, Ian M. Heger, Khoi D. Nguyen, Scott E. Forseen

Publikováno v: Journal of Neurosurgery: Pediatrics. 23:634-638

OBJECTIVEOccipitocervical fusions in the pediatric population are rare but can be challenging because of the smaller anatomy. The procedure is even more exacting in patients with prior suboccipital craniectomy. A proposed method for occipitocervical

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61f2130df463886e9b18ff60b9d80b61
https://doi.org/10.3171/2019.1.peds18583

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Effect of History of Mild Traumatic Brain Injury on Optic Nerve Sheath Diameter Changes after Valsalva Maneuver

Autor: Matthew Lyon, Robert W. Gibson, Hongyan Xu, Ivan Morales, Kyle Friez, Parth Agrawal, Lifang Zhang, Richard Gordon, Ian M. Heger

Publikováno v: Journal of Neurotrauma. 35:695-702

Optic nerve sheath diameter (ONSD) measured by transocular ultrasound is a marker of real-time intracranial pressure (ICP). The objective of this study was to evaluate the association between optic nerve sheath (ONS) dilation after a Valsalva maneuve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc7e735717d92ce74221f40dff4b77be
https://doi.org/10.1089/neu.2017.5164

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IMMU-04. FIRST-IN-CHILDREN PHASE 1B STUDY USING THE IDO PATHWAY INHIBITOR INDOXIMOD IN COMBINATION WITH RADIATION AND CHEMOTHERAPY FOR CHILDREN WITH NEWLY DIAGNOSED DIPG (NCT02502708, NLG2105)

Publikováno v: Neuro-Oncology. 23:i27-i27

Background Diffuse intrinsic pontine glioma (DIPG) is a uniformly fatal brain tumor with no available cure. Indoximod blocks the IDO (indoleamine 2,3-dioxygenase) pathway, thereby reversing IDO-mediated immune suppression in the tumor microenvironmen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3fa04472d0acdd28dd16be05366fe961
https://doi.org/10.1093/neuonc/noab090.112

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IMMU-25. RADIO-IMMUNOTHERAPY USING THE IDO PATHWAY INHIBITOR INDOXIMOD FOR CHILDREN WITH NEWLY-DIAGNOSED DIPG

Autor: Amy Smith, Dolly Aguilera, Ramses F. Sadek, Theodore S. Johnson, Ian M. Heger, Eugene P. Kennedy, Eric Ring, Nicholas N. Vahanian, Bree R. Eaton, Craig Castellino, Nicholas K. Foreman, Charles J. Link, W. Martin, A. Al-Basheer, David H. Munn, Natia Esiashvili, Tobey J. MacDonald

BACKGROUND: Indoximod is an IDO pathway inhibitor with a differentiated mechanism of action directly targeting immune cells to reverse the immune suppression generated by tumors. An ongoing phase-1b/2a study (NCT02502708) using indoximod in combinati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df92f4edc44e262141a0061037d56a4b
https://europepmc.org/articles/PMC6012944/

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Intracranial calcified pseudocyst reaction to a shunt catheter

Autor: Ian M. Heger, Douglas Hughes, Samuel D. Macomson, June Yowtak

Publikováno v: Journal of Neurosurgery: Pediatrics. 13:151-154

A 9-year-old boy with spina bifida, Chiari II malformation, and hydrocephalus presented with signs of increased intracranial pressure consistent with a shunt malfunction. Radiological investigations revealed an intracranial calcified lesion along the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::854ce3bfe0bbc45febd2d9c7142217ce
https://doi.org/10.3171/2013.11.peds12405

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Results of the NLG2105 Phase I Trial Using the IDO Pathway Inhibitor Indoximod, in Combination with Radiation and Chemotherapy, for Children with Newly Diagnosed DIPG

Autor: Bree R. Eaton, Amy Smith, Natia Esiashvili, N. Vahanian, Tobey J. MacDonald, Nicholas K. Foreman, Rafal Pacholczyk, W. Martin, Ramses F. Sadek, A. Al-Basheer, Theodore S. Johnson, Eric Ring, Ian M Heger, E.P. Kennedy, Dolly Aguilera, Michiko Shimoda, David H. Munn, Robert C. Castellino, Zuzana Berrong

Publikováno v: Annals of Oncology. 30:xi38

Background We conducted a phase Ib dose-confirmation study of indoximod with radiation, followed by indoximod with cyclic temozolomide therapy, to evaluate safety and overall survival (OS) in children with newly diagnosed DIPG (diffuse intrinsic pont

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::316e7da67a6e6d0dcd3769f8dcf858b9
https://doi.org/10.1093/annonc/mdz451.010

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Observational Cohort Confirms Optic Nerve Sheath Dilation Post Valsalva in those with Prior mTBI

Autor: Matthew Lyon, Robert Givson, Parth Agrawal, Mary Dement, Lauren East, Chlowe Super, Ian M. Heger

Publikováno v: Neurology. 93:S20.2-S21

ObjectiveThe aim of this study was to prospectively assess the effect of mTBI on optic nerve sheath (ONS) dilation post transient increase in ICP.BackgroundOur cross-sectional study demonstrated that those with a history of mild traumatic brain injur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::92ff6a00e02948a1a4810950a75a53f0
https://doi.org/10.1212/01.wnl.0000581028.74549.d8

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