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Bone marrow transplantation versus chemotherapy in the treatment of very high–risk childhood acute lymphoblastic leukemia in first remission: results from Medical Research Council UKALL X and XI

Autor: Kate A. Wheeler, Susan M. Richards, Clifford C. Bailey, Brenda Gibson, Ian M. Hann, Frank G. H. Hill, Judith M. Chessells

Publikováno v: Blood. 96:2412-2418

The role of bone marrow transplantation (BMT) in first remission of children with high-risk acute lymphoblastic leukemia (ALL) remains unclear. There were 3676 patients (aged 1 to 15 years) entered into the United Kingdom (UK) Medical Research Counci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d67b7f86dcc02085f3216e7da0a298a0
https://doi.org/10.1182/blood.v96.7.2412.h8002412_2412_2418

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Randomized Comparison of DAT Versus ADE as Induction Chemotherapy in Children and Younger Adults With Acute Myeloid Leukemia. Results of the Medical Research Council's 10th AML Trial (MRC AML10)

Autor: Richard F. Stevens, Alan K. Burnett, John K.H. Rees, Anthony H. Goldstone, Richard Gray, Keith Wheatley, Ian M. Hann

Publikováno v: Blood. 89:2311-2318

The relative efficacy and toxicity of the chemotherapeutic agents thioguanine (6TG) and etoposide (VP16) were assessed by a randomized comparison of the DAT (daunorubicin, cytarabine, thioguanine) versus ADE (daunorubicin, cytarabine, etoposide) regi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0d662ab130d38558425b6c52db28b403
https://doi.org/10.1182/blood.v89.7.2311

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Long-term follow-up of relapsed childhood acute lymphoblastic leukaemia

Autor: Judith M, Chessells, Paul, Veys, Helena, Kempski, Patricia, Henley, Ali, Leiper, David, Webb, Ian M, Hann

Publikováno v: British journal of haematology. 123(3)

We have reviewed the outcome after relapse in a cohort of 505 children with acute lymphoblastic leukaemia (ALL) seen at a single institution. The majority of relapses (74%) occurred within 3 years from diagnosis, and most involved the bone marrow alo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4a70742da17d5c8a0878d43baa81cec6
https://pubmed.ncbi.nlm.nih.gov/14616997

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Paediatric myelodysplastic syndromes and juvenile myelomonocytic leukaemia in the UK: a population-based study of incidence and survival

Autor: S Jane, Passmore, Judith M, Chessells, Helena, Kempski, Ian M, Hann, Pat A, Brownbill, Charles A, Stiller

Publikováno v: British journal of haematology. 121(5)

We aimed to identify and classify cases of paediatric myelodysplastic syndromes (MDS) occurring in Britain to estimate the incidence of this rare group of diseases, investigate the results of therapy and identify prognostic risk factors. Patients age

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bc6b6916e4a16cda2d1131707cb7d877
https://pubmed.ncbi.nlm.nih.gov/14510964

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The value of allogeneic bone marrow transplant in patients with acute myeloid leukaemia at differing risk of relapse: results of the UK MRC AML 10 trial

Autor: Alan K, Burnett, Keith, Wheatley, Anthony H, Goldstone, Richard F, Stevens, Ian M, Hann, John H K, Rees, Georgina, Harrison

Publikováno v: British journal of haematology. 118(2)

Patients under 55 years in the United Kingdom Medical Research Council Acute Myeloid Leukaemia 10 trial who entered complete remission were tissue typed (n = 1063). Four hundred and nineteen had a matched sibling donor and 644 had no match. When comp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1885f5ac0e4d3b0ce9ca2ea148808856
https://pubmed.ncbi.nlm.nih.gov/12139722

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Failure of a new protocol to improve treatment results in paediatric lymphoblastic leukaemia: lessons from the UK Medical Research Council trials UKALL X and UKALL XI

Autor: Judith M, Chessells, Georgina, Harrison, Susan M, Richards, Brenda E, Gibson, Clifford C, Bailey, Frank G H, Hill, Ian M, Hann

Publikováno v: British journal of haematology. 118(2)

The impact of various types of intensification therapy was examined in a cohort of 3617 children aged 1-14 years with acute lymphoblastic leukaemia (ALL) enrolled in the Medical Research Council (MRC) UKALL X (1985-90) and UKALL XI (1990-97) trials.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1d950a2088d94c28053e7ce1c81df385
https://pubmed.ncbi.nlm.nih.gov/12139731

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