Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Ian M. Garner"'
Publikováno v:
STAR Protocols, Vol 1, Iss 2, Pp 100079- (2020)
Summary: Disrupted chromatin regulatory processes contribute to the development of cancer, in particular pancreatic ductal adenocarcinoma. The assay for transposase accessible chromatin with high-throughput sequencing (ATAC-seq) is typically used to
Externí odkaz:
https://doaj.org/article/e4e2cd0efce24cf59e37f7293e85cc41
Autor:
Erick Loomis, Ian M. Garner, Robert S. Brown, John Gallon, Leigh Brody, Edward Curry, James M. Flanagan, Nicholas Martin
Publikováno v:
Clinical Epigenetics
Background Resistance to DNA damaging chemotherapies leads to cancer treatment failure and poor patient prognosis. We investigated how genomic distribution of accessible chromatin sites is altered during acquisition of cisplatin resistance using matc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45e8aadf71716840ceb347e3ee21b29a
http://hdl.handle.net/10044/1/89728
http://hdl.handle.net/10044/1/89728
Autor:
Susan L. Mason, Matthew J. Fuchter, S. Spear, Darren Ennis, McNamara S, Lynn McGarry, Peter D. Adams, Pavlina Spiliopoulou, B. Brown, Grundland-Freile F, Iain A. McNeish, Marina Natoli, H. B. Mirza, Ian M. Garner, Cheng Z, Kevin G. Blyth, Patricia Roxburgh
Ovarian high-grade serous carcinoma (HGSC) prognosis correlates directly with presence of intratumoral lymphocytes. However, cancer immunotherapy has yet to achieve meaningful survival benefit in patients with HGSC. Epigenetic silencing of immunostim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0249e9cee47341c1d0f49e6400550d36
https://doi.org/10.1101/2021.05.09.443282
https://doi.org/10.1101/2021.05.09.443282
Publikováno v:
STAR Protocols
STAR Protocols, Vol 1, Iss 2, Pp 100079-(2020)
STAR Protocols, Vol 1, Iss 2, Pp 100079-(2020)
Summary Disrupted chromatin regulatory processes contribute to the development of cancer, in particular pancreatic ductal adenocarcinoma. The assay for transposase accessible chromatin with high-throughput sequencing (ATAC-seq) is typically used to s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cedee976643c7edcb0279df2cd0d8cc5
https://pubmed.ncbi.nlm.nih.gov/33111113
https://pubmed.ncbi.nlm.nih.gov/33111113
Autor:
Holly Brunton, Giuseppina Caligiuri, Richard Cunningham, Rosie Upstill-Goddard, Ulla-Maja Bailey, Ian M. Garner, Craig Nourse, Stephan Dreyer, Marc Jones, Kim Moran-Jones, Derek W. Wright, Viola Paulus-Hock, Colin Nixon, Gemma Thomson, Nigel B. Jamieson, Grant A. McGregor, Lisa Evers, Colin J. McKay, Aditi Gulati, Rachel Brough, Ilirjana Bajrami, Stephen J. Pettitt, Michele L. Dziubinski, Simon T. Barry, Robert Grützmann, Robert Brown, Edward Curry, Marina Pajic, Elizabeth A. Musgrove, Gloria M. Petersen, Emma Shanks, Alan Ashworth, Howard C. Crawford, Diane M. Simeone, Fieke E.M. Froeling, Christopher J. Lord, Debabrata Mukhopadhyay, Christian Pilarsky, Sean E. Grimmond, Jennifer P. Morton, Owen J. Sansom, David K. Chang, Peter J. Bailey, Andrew V. Biankin, Sarah Allison, Susanna L. Cooke, Paul Grimwood, Shane Kelly, John Marshall, Brian McDade, Daniel McElroy, Donna Ramsay, Selma Rebus, Jane Hair, Paul Westwood, Nicola Williams, Fraser Duthie, Amber L. Johns, Amanda Mawson, Christopher J. Scarlett, Mary-Anne L. Brancato, Sarah J. Rowe, Skye H. Simpson, Mona Martyn-Smith, Michelle T. Thomas, Lorraine A. Chantrill, Venessa T. Chin, Angela Chou, Mark J. Cowley, Jeremy L. Humphris, R. Scott Mead, Adnan M. Nagrial, Jessica Pettit, Mark Pinese, Ilse Rooman, Jianmin Wu, Jiang Tao, Renee DiPietro, Clare Watson, Angela Steinmann, Hong Ching Lee, Rachel Wong, Andreia V. Pinho, Marc Giry-Laterriere, Roger J. Daly, Robert L. Sutherland, Sean M. Grimmond, Nicola Waddell, Karin S. Kassahn, David K. Miller, Peter J. Wilson, Ann-Marie Patch, Sarah Song, Ivon Harliwong, Senel Idrisoglu, Ehsan Nourbakhsh, Suzanne Manning, Shivangi Wani, Milena Gongora, Matthew Anderson, Oliver Holmes, Conrad Leonard, Darrin Taylor, Scott Wood, Christina Xu, Katia Nones, J. Lynn Fink, Angelika Christ, Tim Bruxner, Nicole Cloonan, Felicity Newell, John V. Pearson, Michael Quinn, Shivashankar Nagaraj, Stephen Kazakoff, Nick Waddell, Keerthana Krisnan, Kelly Quek, David Wood, Jaswinder S. Samra, Anthony J. Gill, Nick Pavlakis, Alex Guminski, Christopher Toon, Ray Asghari, Neil D. Merrett, Darren Pavey, Amitabha Das, Peter H. Cosman, Kasim Ismail, Chelsie O’Connnor, Vincent W. Lam, Duncan McLeod, Henry C. Pleass, Arthur Richardson, Virginia James, James G. Kench, Caroline L. Cooper, David Joseph, Charbel Sandroussi, Michael Crawford, James Gallagher, Michael Texler, Cindy Forest, Andrew Laycock, Krishna P. Epari, Mo Ballal, David R. Fletcher, Sanjay Mukhedkar, Nigel A. Spry, Bastiaan DeBoer, Ming Chai, Nikolajs Zeps, Maria Beilin, Kynan Feeney, Nan Q. Nguyen, Andrew R. Ruszkiewicz, Chris Worthley, Chuan P. Tan, Tamara Debrencini, John Chen, Mark E. Brooke-Smith, Virginia Papangelis, Henry Tang, Andrew P. Barbour, Andrew D. Clouston, Patrick Martin, Thomas J. O’Rourke, Amy Chiang, Jonathan W. Fawcett, Kellee Slater, Shinn Yeung, Michael Hatzifotis, Peter Hodgkinson, Christopher Christophi, Mehrdad Nikfarjam, Angela Mountain, James R. Eshleman, Ralph H. Hruban, Anirban Maitra, Christine A. Iacobuzio-Donahue, Richard D. Schulick, Christopher L. Wolfgang, Richard A. Morgan, Mary Hodgin, Aldo Scarpa, Rita T. Lawlor, Stefania Beghelli, Vincenzo Corbo, Maria Scardoni, Claudio Bassi, Margaret A. Tempero, Janet S. Graham
Pancreatic ductal adenocarcinoma (PDAC) can be divided into transcriptomic subtypes with two broad lineages referred to as classical (pancreatic) and squamous. We find that these two subtypes are driven by distinct metabolic phenotypes. Loss of genes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b5ec52000a29e72c3d00ca316985478
http://hdl.handle.net/11562/1031969
http://hdl.handle.net/11562/1031969
Autor:
Sawyer Hu, Ian M. Garner, Iain A. McNeish, Matthew J. Fuchter, Robert M Brown, Zhuyan Su, Yue Wu
Publikováno v:
Cancer Research. 81:2066-2066
Defective DNA damage response (DDR) is a hallmark of high grade serous ovarian cancer (HGSOC). Genetic and epigenomic aberrations in DDR pathways including homologous recombination (BRCA1/BRCA2) and non-homologous end joining (PARP-1) make some HGSOC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::236959c75d27bdb9f8da263ea61a62e7
https://doi.org/10.1158/1538-7445.am2021-2066
https://doi.org/10.1158/1538-7445.am2021-2066
Autor:
Holly Brunton, Giuseppina Caligiuri, Richard Cunningham, Rosie Upstill-Goddard, Ulla-Maja Bailey, Ian M. Garner, Craig Nourse, Stephan Dreyer, Marc Jones, Kim Moran-Jones, Derek W. Wright, Viola Paulus-Hock, Colin Nixon, Gemma Thomson, Nigel Jamieson, Grant A. McGregor, Lisa Evers, Colin J. McKay, Aditi Gulati, Rachel Brough, Ilirjana Bajrami, Stephen Pettit, Michele L. Dziubinski, Simon T. Barry, Robert Grützmann, Robert Brown, Edward Curry, Glasgow Precision Oncology Laboratory, Australian Pancreatic Cancer Genome Initiative, Marina Pajic, Elizabeth A. Musgrove, Gloria Petersen, Emma Shanks, Alan Ashworth, Howard C. Crawford, Diane M. Simeone, Fieke E.M. Froeling, Christopher J. Lord, Debabrata Mukhopadhyay, Christian Pilarsky, Sean E. Grimmond, Jennifer P. Morton, Owen J. Sansom, David K. Chang, Peter Bailey, Andrew V. Biankin
Publikováno v:
SSRN Electronic Journal.
The identification of molecularly defined subgroups of Pancreatic ductal Adenocarcinoma (PDAC) has the potential to transform clinical practice. There is now a growing consensus that PDAC can be divided into transcriptomic subtypes with 2 broad linag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::775f120d1a30418ec9c42c5feac9a429
https://doi.org/10.2139/ssrn.3430714
https://doi.org/10.2139/ssrn.3430714