Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Ian M. C. Dixon"'
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 10, p 3207 (2018)
Following cardiac injury, fibroblasts are activated and are termed as myofibroblasts, and these cells are key players in extracellular matrix (ECM) remodeling and fibrosis, itself a primary contributor to heart failure. Nutraceuticals have been shown
Externí odkaz:
https://doaj.org/article/6ad4f8c57b0a46eab2e97482a0e76046
Autor:
Raghu S Nagalingam, Sikta Chattopadhyaya, Danah S Al-Hattab, David Y C Cheung, Leah Y Schwartz, Sayantan Jana, Nina Aroutiounova, D Allison Ledingham, Teri L Moffatt, Natalie M Landry, Rushita A Bagchi, Ian M C Dixon, Jeffrey T Wigle, Gavin Y Oudit, Zamaneh Kassiri, Davinder S Jassal, Michael P Czubryt
Publikováno v:
European Heart Journal. 43:4739-4750
Aims In response to pro-fibrotic signals, scleraxis regulates cardiac fibroblast activation in vitro via transcriptional control of key fibrosis genes such as collagen and fibronectin; however, its role in vivo is unknown. The present study assessed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a3e1676f5ff089c0cab8c5222b495a4
https://doi.org/10.1093/eurheartj/ehac362
https://doi.org/10.1093/eurheartj/ehac362
Publikováno v:
The Renin Angiotensin System in Cardiovascular Disease ISBN: 9783031149511
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e44fb2717172107b5dd161e048c4513
https://doi.org/10.1007/978-3-031-14952-8_13
https://doi.org/10.1007/978-3-031-14952-8_13
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2299
Two-dimensional cell culture is the primary method employed for proof-of-concept studies in most molecular biology labs. While immortalized cell lines are convenient and easy to maintain for extended periods in vitro, their inability to accurately re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ca0399844a3559275437783763f58ab8
https://pubmed.ncbi.nlm.nih.gov/34028743
https://pubmed.ncbi.nlm.nih.gov/34028743
Publikováno v:
Advances in experimental medicine and biology. 1132
Cardiac muscle (the myocardium) is a unique arrangement of atria and ventricles that are spatially and electrically separated by a fibrous border. The spirally-arranged myocytes in both left and right ventricles are tethered by the component molecule
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9e7ed9b51910caf41ce72aea85fe287d
https://pubmed.ncbi.nlm.nih.gov/31037622
https://pubmed.ncbi.nlm.nih.gov/31037622
Autor:
Saeid, Ghavami, Behzad, Yeganeh, Amir A, Zeki, Shahla, Shojaei, Nicholas J, Kenyon, Sean, Ott, Afshin, Samali, John, Patterson, Javad, Alizadeh, Adel Rezaei, Moghadam, Ian M C, Dixon, Helmut, Unruh, Darryl A, Knight, Martin, Post, Thomas, Klonisch, Andrew J, Halayko
Publikováno v:
American journal of physiology. Lung cellular and molecular physiology. 314(3)
Idiopathic pulmonary fibrosis (IPF) is a lethal fibrotic lung disease in adults with limited treatment options. Autophagy and the unfolded protein response (UPR), fundamental processes induced by cell stress, are dysregulated in lung fibroblasts and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4644534ffd55636d945f61f3d5af2405
https://pubmed.ncbi.nlm.nih.gov/29074489
https://pubmed.ncbi.nlm.nih.gov/29074489
Autor:
Agata M, Wasik, Jerzy, Grabarek, Aleksandar, Pantovic, Artur, Cieślar-Pobuda, Hamid R, Asgari, Caspar, Bundgaard-Nielsen, Mehrdad, Rafat, Ian M C, Dixon, Saeid, Ghavami, Marek J, Łos
Publikováno v:
International review of cell and molecular biology. 308
Rapid progress made in various areas of regenerative medicine in recent years occurred both at the cellular level, with the Nobel prize-winning discovery of reprogramming (generation of induced pluripotent stem (iPS) cells) and also at the biomateria
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1c477780b569d1ed84fcf5993d011774
https://pubmed.ncbi.nlm.nih.gov/24411172
https://pubmed.ncbi.nlm.nih.gov/24411172
Publikováno v:
Canadian journal of physiology and pharmacology. 87(10)
Recent studies demonstrate the critical role of the extracellular matrix in the organization of parenchymal cells in the heart. Thus, an understanding of the modes of regulation of matrix production by cardiac myofibroblasts is essential. Transformin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4fa6cf26c9ce22ebbac8ee0714471295
https://pubmed.ncbi.nlm.nih.gov/19898560
https://pubmed.ncbi.nlm.nih.gov/19898560
Autor:
Darren H, Freed, Michael C, Moon, Anna M, Borowiec, Stephen C, Jones, Peter, Zahradka, Ian M C, Dixon
Publikováno v:
Molecular and cellular biochemistry. 254(1-2)
Cardiotrophin-1 (CT-1), a member of the IL-6 family of cytokines, has been shown to be elevated in the serum of patients with ischemic heart disease and valvular heart disease, and induces cardiomyocyte hypertrophy in vitro. We investigated expressio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c1861a7655cb80047281e33845c06e33
https://pubmed.ncbi.nlm.nih.gov/14674704
https://pubmed.ncbi.nlm.nih.gov/14674704
Autor:
Leonard Golfman, Ian M. C. Dixon, Nobuakira Takeda, Anton Lukas, Krishnamurti Dakshinamurti, Naranjan S. Dhalla
Publikováno v:
Molecular and Cellular Effects of Nutrition on Disease Processes ISBN: 9781461376415
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b7bc4280e1aed116d4fd7ed15b371051
https://doi.org/10.1007/978-1-4615-5763-0_11
https://doi.org/10.1007/978-1-4615-5763-0_11