Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Ian M. Ahearn"'
Autor:
Vignesh Ramachandran, Efe Kakpovbia, Michelle C. Juarez, Neil Jairath, Andjela Nemcevic, Christine C. Akoh, Ian M. Ahearn, Ian W. Tattersall, Nayoung Lee, Jo-Ann M. Latkowski, John G. Zampella
Publikováno v:
Military Medical Research, Vol 11, Iss 1, Pp 1-3 (2024)
Externí odkaz:
https://doaj.org/article/64f02f7e99e14fb4bd756417539c3d92
Autor:
Xue Chen, Haidong Yao, Muhammad Kashif, Gwladys Revêchon, Maria Eriksson, Jianjiang Hu, Ting Wang, Yiran Liu, Elin Tüksammel, Staffan Strömblad, Ian M Ahearn, Mark R Philips, Clotilde Wiel, Mohamed X Ibrahim, Martin O Bergo
Publikováno v:
eLife, Vol 10 (2021)
A farnesylated and methylated form of prelamin A called progerin causes Hutchinson-Gilford progeria syndrome (HGPS). Inhibiting progerin methylation by inactivating the isoprenylcysteine carboxylmethyltransferase (ICMT) gene stimulates proliferation
Externí odkaz:
https://doaj.org/article/af9f4ea451d04c5cba3ce05449cb18c3
Autor:
Aristotelis Tsirigos, Subhadip Mukhopadhyay, Ting Chen, Mark R. Philips, Jiehui Deng, Hailin Ding, Val Pyon, Ian M. Ahearn, Fei Li, Mirna Bulatović, Antonio Marzio, Justin F. Gainor, Shuai Li, Cassandra Thakurdin, Heather Silver, Peter S. Hammerman, David H. Peng, Eli Rothenberg, John V. Heymach, Michele Pagano, Vajira K. Weerasekara, Yuanwang Pan, Hai Hu, Nathanael S. Gray, Charles M. Perou, Aatish Thennavan, Thales Papagiannakopoulos, Han Han, Baishan Jiang, John T. Poirier, Eleni Papadopoulos, Igor Dolgalev, Kwok-Kin Wong, Gordon J. Freeman, Charles M. Rudin, Nabeel Bardeesy, Eric S. Wang, Jie Li
Publikováno v:
Nature cancer
Inactivating mutations in LKB1/STK11 are present in roughly 20% of nonsmall cell lung cancers (NSCLC) and portend poor response to anti-PD-1 immunotherapy. Unexpectedly, we found that LKB1 deficiency correlated with elevated tumor mutational burden (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aafbf6fd4e394c7de9b24b44901bf672
https://pubmed.ncbi.nlm.nih.gov/35122020
https://pubmed.ncbi.nlm.nih.gov/35122020
Autor:
Jianjiang Hu, Maria Eriksson, Clotilde Wiel, Ian M. Ahearn, Ting Wang, Staffan Strömblad, Martin O. Bergo, Elin Tüksammel, Muhammad Kashif, Mohamed X. Ibrahim, Mark R. Philips, Haidong Yao, Gwladys Revêchon, Yiran Liu, Xue Chen
Publikováno v:
eLife
eLife, Vol 10 (2021)
eLife, Vol 10 (2021)
A farnesylated and methylated form of prelamin A called progerin causes Hutchinson-Gilford progeria syndrome (HGPS). Inhibiting progerin methylation by inactivating the isoprenylcysteine carboxylmethyltransferase (ICMT) gene stimulates proliferation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4025cace094c6dcae00415bb8b599c8c
https://doi.org/10.7554/elife.63284
https://doi.org/10.7554/elife.63284
Autor:
Elin Tüksammel, Clotilde Wiel, Mark R. Philips, Ting Wang, Mohamed X. Ibrahim, Haidong Yao, Staffan Strömblad, Gwladys Revêchon, Muhammad Kashif, Jianjiang Hu, Maria Eriksson, Ian M. Ahearn, Yiran Liu, Martin O. Bergo, Xue Chen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8714222d18d7b1841bfe7780f20f834
https://doi.org/10.7554/elife.63284.sa2
https://doi.org/10.7554/elife.63284.sa2
Autor:
Mark R. Philips, Caroline R. Amendola, Xiarong Shi, Stephen Viviano, Sana Badri, Jane A. Skok, Nicole Fehrenbacher, Joseph Schlessinger, Benjamin E. Turk, David A. Calderwood, Leena Kuruvilla, Ian M. Ahearn, James P. Mahaffey, Mo Zhou, Wenjuan Su
Publikováno v:
Proc Natl Acad Sci U S A
Inhibiting membrane association of RAS has long been considered a rational approach to anticancer therapy, which led to the development of farnesyltransferase inhibitors (FTIs). However, FTIs proved ineffective against KRAS-driven tumors. To reveal a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a64bac1adc24c2b263a1ed25f2cffc2
https://europepmc.org/articles/PMC7749360/
https://europepmc.org/articles/PMC7749360/
Publikováno v:
Life Science Alliance
Among the RAS isoforms, NRAS uniquely requires carboxyl methylation by ICMT for delivery to the plasma membrane because of having only a single palmitoylation as a second targeting signal.
Isoprenylcysteine carboxyl methyltransferase (ICMT) is t
Isoprenylcysteine carboxyl methyltransferase (ICMT) is t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e57e232da610ece86cfbe86f884ba8c
https://pubmed.ncbi.nlm.nih.gov/33579760
https://pubmed.ncbi.nlm.nih.gov/33579760
Autor:
Ruimin Pan, Adam Mor, Anna S Tocheva, Kieran Adam, Xiang-Peng Kong, Ian M. Ahearn, Elliot A. Philips, Antonio Garcia-España
Programmed cell death protein 1 (PD-1) is an inhibitory receptor on T lymphocytes that is critical for modulating adaptive immunity. As such, it has been successfully exploited for cancer immunotherapy. Programmed death ligand 1 (PD-L1) and PD-L2 are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd378245098c4c3f71f1e6bd40eb1334
https://europepmc.org/articles/PMC7135984/
https://europepmc.org/articles/PMC7135984/
Autor:
Heidi H. Wiener, Ian M. Ahearn, Yong Zhou, Mark R. Philips, Mo Zhou, John F. Hancock, Caroline Liot, Wenjuan Su
Publikováno v:
The Journal of Cell Biology
Mutated N-Ras causes leukemia and melanoma when properly delivered to cellular membranes. Here, VPS35, a component of the retromer, is shown to carry N-Ras from one membrane compartment to another. Thus, VPS35 may be a target for anticancer drug disc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::238f17fe6676ca9f65c026bc99259846
https://doi.org/10.1083/jcb.201604061
https://doi.org/10.1083/jcb.201604061
The three human RAS genes encode four proteins that play central roles in oncogenesis by acting as binary molecular switches that regulate signaling pathways for growth and differentiation. Each is subject to a set of post-translational modifications
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19dacf884cf87111c7f47fdce99fce78
https://europepmc.org/articles/PMC6035883/
https://europepmc.org/articles/PMC6035883/