Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Ian M Thornell"'
Autor:
Emma M Stapleton, Kathy Keck, Robert Windisch, Mallory R Stroik, Andrew L Thurman, Joseph Zabner, Ian M Thornell, Alejandro A Pezzulo, Julia Klesney-Tait, Alejandro P Comellas
Publikováno v:
PLoS ONE, Vol 17, Iss 6, p e0269647 (2022)
IntroductionVitamin D supplementation has been suggested to enhance immunity during respiratory infection season. We tested the effect of active vitamin D (calcitriol) supplementation on key airway innate immune mechanisms in vitro.MethodsPrimary hum
Externí odkaz:
https://doaj.org/article/8ada10e21bdc48dc801696506f27cec3
Autor:
Gopinathan Gangadharan Nambiar, Sussette Gonzalez Szachowicz, Christian F. Zirbes, Jared J. Hill, Linda S. Powers, David K. Meyerholz, Ian M. Thornell, David A. Stoltz, Anthony J. Fischer
Publikováno v:
Frontiers in Pediatrics, Vol 12 (2024)
IntroductionMeconium ileus (MI) is a life-threatening obstruction of the intestines affecting ∼15% of newborns with cystic fibrosis (CF). Current medical treatments for MI often fail, requiring surgical intervention. MI typically occurs in newborns
Externí odkaz:
https://doaj.org/article/1b4483c0066844d2a9383238af8cf27f
Autor:
Lei Lei, Soumba Traore, Guillermo S. Romano Ibarra, Philip H. Karp, Tayyab Rehman, David K. Meyerholz, Joseph Zabner, David A. Stoltz, Patrick L. Sinn, Michael J. Welsh, Paul B. McCray Jr., Ian M. Thornell
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 20 (2023)
The volume and composition of a thin layer of liquid covering the airway surface defend the lung from inhaled pathogens and debris. Airway epithelia secrete Cl– into the airway surface liquid through cystic fibrosis transmembrane conductance regula
Externí odkaz:
https://doaj.org/article/2cd2777105f44a3382766c3e36dc6f28
Publikováno v:
Physiological Reports, Vol 8, Iss 19, Pp n/a-n/a (2020)
Abstract Introduction One method for assessing the in vitro response to CFTR‐modulating compounds is by analysis of epithelial monolayers in an Ussing chamber, where the apical and basolateral surfaces are isolated and the potential difference, sho
Externí odkaz:
https://doaj.org/article/cbecdc03fbdc48c6b66e43318d5afcf5
Autor:
Camilo Cano Portillo, Raul Villacreses, Andrew L. Thurman, Alejandro A. Pezzulo, Joseph Zabner, Ian M. Thornell
Publikováno v:
American Journal of Physiology-Cell Physiology. 323:C1044-C1051
Na/K ATPase activity is essential for ion transport across epithelia. FXYD3, a γ subunit of the Na/K ATPase, is expressed in the airway, but its function remains undetermined. Single-cell RNA sequencing and immunohistochemistry revealed that FXYD3 l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c490d504200d1c5db0038017dbea1744
https://doi.org/10.1152/ajpcell.00047.2022
https://doi.org/10.1152/ajpcell.00047.2022
Autor:
Andrew L. Thurman, Xiaopeng Li, Raul Villacreses, Wenjie Yu, Huiyu Gong, Steven E. Mather, Guillermo S. Romano-Ibarra, David K. Meyerholz, David A. Stoltz, Michael J. Welsh, Ian M. Thornell, Joseph Zabner, Alejandro A. Pezzulo
Publikováno v:
American journal of respiratory cell and molecular biology. 66(6)
Lack of CFTR (cystic fibrosis transmembrane conductance regulator) affects the transcriptome, composition, and function of large and small airway epithelia in people with advanced cystic fibrosis (CF); however, whether lack of CFTR causes cell-intrin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdc3ff6fb1e5a08d17861be6e46f3300
https://pubmed.ncbi.nlm.nih.gov/35294854
https://pubmed.ncbi.nlm.nih.gov/35294854
Autor:
Annie Ehler, Xiaopeng Li, Raul Villacreses, David K. Meyerholz, Steven E Mather, Adam Zabner, Joseph Zabner, David A. Stoltz, Christian M Brommel, Ian M. Thornell, Lin Lu, Julio Noriega
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 65:146-156
In a newborn pig cystic fibrosis (CF) model, the ability of gland-containing airways to fight infection was affected by at least two major host-defense defects: impaired mucociliary transport and a...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::64cc05904a8f53bf5df6bd364a6a5e14
https://doi.org/10.1165/rcmb.2020-0349oc
https://doi.org/10.1165/rcmb.2020-0349oc
Autor:
Camilo Cano Portillo, Raul Villacreses, Andrew Thurman, Alejandro Pezzulo, Joseph Zabner, Ian M. Thornell
Publikováno v:
The FASEB Journal. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ba36bf084c3bf5306fb50c7ce4b2a60
https://doi.org/10.1096/fasebj.2022.36.s1.r6263
https://doi.org/10.1096/fasebj.2022.36.s1.r6263
Autor:
Ian M. Thornell, Ping Tan, Tayyab Rehman, Michael E. Duffey, Guillermo S Romano Ibarra, Alejandro A. Pezzulo, Philip H. Karp, Andrew L Thurman, Michael J. Welsh
Publikováno v:
American Journal of Physiology-Cell Physiology
The pH of airway surface liquid (ASL) is a key factor that determines respiratory host defense; ASL acidification impairs and alkalinization enhances key defense mechanisms. Under healthy conditions, airway epithelia secrete base ([Formula: see text]
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b8dce1ac5ddec6cb310439104be1963
https://doi.org/10.1152/ajpcell.00112.2020
https://doi.org/10.1152/ajpcell.00112.2020
Publikováno v:
The Journal of Physiology. 598:4307-4320
Key points Cl- and HCO3 - had similar paracellular permeabilities in human airway epithelia. PCl /PNa of airway epithelia was unaltered by pH 7.4 vs. pH 6.0 solutions. Under basal conditions, calculated paracellular HCO3 - flux was secretory. Cytokin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53a467568d1d562a116f2cd74d4fa508
https://doi.org/10.1113/jp280120
https://doi.org/10.1113/jp280120