Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Ian M Sealy"'
Autor:
Christopher M Dooley, Neha Wali, Ian M Sealy, Richard J White, Derek L Stemple, John E Collins, Elisabeth M Busch-Nentwich
Publikováno v:
PLoS Genetics, Vol 15, Iss 6, p e1008213 (2019)
The neural crest (NC) is a vertebrate-specific cell type that contributes to a wide range of different tissues across all three germ layers. The gene regulatory network (GRN) responsible for the formation of neural crest is conserved across vertebrat
Externí odkaz:
https://doaj.org/article/7a88334569114521834d1b3b5347eaa6
Autor:
Rodrigo M Young, Thomas A Hawkins, Florencia Cavodeassi, Heather L Stickney, Quenten Schwarz, Lisa M Lawrence, Claudia Wierzbicki, Bowie YL Cheng, Jingyuan Luo, Elizabeth Mayela Ambrosio, Allison Klosner, Ian M Sealy, Jasmine Rowell, Chintan A Trivedi, Isaac H Bianco, Miguel L Allende, Elisabeth M Busch-Nentwich, Gaia Gestri, Stephen W Wilson
Publikováno v:
eLife, Vol 8 (2019)
The vertebrate eye originates from the eye field, a domain of cells specified by a small number of transcription factors. In this study, we show that Tcf7l1a is one such transcription factor that acts cell-autonomously to specify the eye field in zeb
Externí odkaz:
https://doaj.org/article/f4af83f9041b4ce4a7ad63e0592a4d05
Autor:
Richard J White, John E Collins, Ian M Sealy, Neha Wali, Christopher M Dooley, Zsofia Digby, Derek L Stemple, Daniel N Murphy, Konstantinos Billis, Thibaut Hourlier, Anja Füllgrabe, Matthew P Davis, Anton J Enright, Elisabeth M Busch-Nentwich
Publikováno v:
eLife, Vol 6 (2017)
We have produced an mRNA expression time course of zebrafish development across 18 time points from 1 cell to 5 days post-fertilisation sampling individual and pools of embryos. Using poly(A) pulldown stranded RNA-seq and a 3′ end transcript counti
Externí odkaz:
https://doaj.org/article/9bd40316a80c4e14af28a219f25761c8
Autor:
Catherine M Scahill, Zsofia Digby, Ian M Sealy, Sonia Wojciechowska, Richard J White, John E Collins, Derek L Stemple, Till Bartke, Marie E Mathers, E Elizabeth Patton, Elisabeth M Busch-Nentwich
Publikováno v:
PLoS Genetics, Vol 13, Iss 8, p e1006959 (2017)
KDM2A is a histone demethylase associated with transcriptional silencing, however very little is known about its in vivo role in development and disease. Here we demonstrate that loss of the orthologue kdm2aa in zebrafish causes widespread transcript
Externí odkaz:
https://doaj.org/article/23481b52219a4a36ac52d959488d8d1d
Autor:
Vincenzo Torraca, Richard J. White, Ian M. Sealy, Maria Mazon-Moya, Gina Duggan, Alexandra R. Willis, Elisabeth M. Busch-Nentwich, Serge Mostowy
Publikováno v:
Disease Models & Mechanisms, Vol 17, Iss 1 (2024)
Externí odkaz:
https://doaj.org/article/8c1b711738714e84b10742da837b49e8
Autor:
Catherine M. Scahill, Zsofia Digby, Ian M. Sealy, Richard J. White, Neha Wali, John E. Collins, Derek L. Stemple, Elisabeth M. Busch-Nentwich
Publikováno v:
Wellcome Open Research, Vol 2 (2018)
Background: Mutations in proteins involved in telomere maintenance lead to a range of human diseases, including dyskeratosis congenita, idiopathic pulmonary fibrosis and cancer. Telomerase functions to add telomeric repeats back onto the ends of chro
Externí odkaz:
https://doaj.org/article/7549ca017f244f3089066073b1bfff71
Autor:
Vincenzo Torraca, Richard J. White, Ian M. Sealy, Maria Mazon-Moya, Gina Duggan, Alexandra Willis, Elisabeth M. Busch-Nentwich, Serge Mostowy
Shigella flexneri is a human adapted pathovar of Escherichia coli that can invade the intestinal epithelium, causing inflammation and bacillary dysentery. Although an important human pathogen, the host response to S. flexneri is poorly understood. Ze
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd856366dd170a8f28d44d17f6f47d3f
https://doi.org/10.1101/2022.10.03.510593
https://doi.org/10.1101/2022.10.03.510593
Autor:
Eva Sheardown, Aleksandra M. Mech, Maria Elena Miletto Petrazzini, Adele Leggieri, Agnieszka Gidziela, Saeedeh Hosseinian, Ian M. Sealy, Jose V. Torres-Perez, Elisabeth M. Busch-Nentwich, Margherita Malanchini, Caroline H. Brennan
Publikováno v:
Neurosci Biobehav Rev
Psychiatric disorders represent a significant burden in our societies. Despite the convincing evidence pointing at gene and gene-environment interaction contributions, the role of genetics in the aetiology of psychiatric disease is still poorly under
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76f29439c061d4cbfc8440ffdd823d52
https://europepmc.org/articles/PMC9016269/
https://europepmc.org/articles/PMC9016269/
Autor:
Aleksandra M. Mech, Munise Merteroglu, Ian M. Sealy, Muy-Teck Teh, Richard J. White, William Havelange, Caroline H. Brennan, Elisabeth M. Busch-Nentwich
Publikováno v:
Frontiers in Psychiatry
Frontiers in Psychiatry, Vol 12 (2022)
Frontiers in Psychiatry, Vol 12 (2022)
Developmental consequences of prenatal drug exposure have been reported in many human cohorts and animal studies. The long-lasting impact on the offspring—including motor and cognitive impairments, cranial and cardiac anomalies and increased preval
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c8b5ae318240dbda1619b309ca30a2a
http://europepmc.org/articles/PMC8785235
http://europepmc.org/articles/PMC8785235
Autor:
Karin Tuschl, Richard J. White, Chintan Trivedi, Leonardo E. Valdivia, Stephanie Niklaus, Isaac H. Bianco, Chris Dadswell, Ramón González-Méndez, Ian M. Sealy, Stephan C. F. Neuhauss, Corinne Houart, Jason Rihel, Stephen W. Wilson, Elisabeth M. Busch-Nentwich
Publikováno v:
Disease modelsmechanisms. 15(6)
Manganese neurotoxicity is a hallmark of hypermanganesemia with dystonia 2, an inherited manganese transporter defect caused by mutations in SLC39A14. To identify novel potential targets of manganese neurotoxicity, we performed transcriptome analysis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bd24a98fd0dca92f6ab8e8e1169bd8b
https://pubmed.ncbi.nlm.nih.gov/35514229
https://pubmed.ncbi.nlm.nih.gov/35514229