Zobrazeno 1 - 10
of 356
pro vyhledávání: '"Ian M Orme"'
Autor:
Brennan, Patrick J.
Publikováno v:
In Tuberculosis September 2018 112:A1-A2
Autor:
Patrick J. Brennan
Publikováno v:
Tuberculosis. 112:A1-A2
Autor:
Ian M. Orme, Marcela I. Henao-Tamayo
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
The purpose of vaccination against tuberculosis and other diseases is to establish a heightened state of acquired specific resistance in which the memory immune response is capable of mediating an accelerated and magnified expression of protection to
Externí odkaz:
https://doaj.org/article/8722292dedfb4f978b107da00a632699
Autor:
Crystal A. Shanley, Marcela Henao-Tamayo, Ian M. Orme, Taru S. Dutt, Brendan K. Podell, Steven A. Porcelli, Bing Chen, Annie Zhi Dai, Burton Karger, Regy Lukose, Mei Chen, John Kim, Sangeeta Tiwari, Andrés Obregón-Henao, William R. Jacobs, John Chan, Amy Fox
Publikováno v:
Vaccine
Although vaccination with BCG prevents disseminated forms of childhood tuberculosis (TB), it does not protect against pulmonary infection or Mycobacterium tuberculosis (Mtb) transmission. In this study, we generated a complete deletion mutant of the
Autor:
Marcela Henao-Tamayo, Crystal A Shanley, Deepshikha Verma, Andrew Zilavy, Margaret C Stapleton, Synthia K Furney, Brendan Podell, Ian M Orme
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0136500 (2015)
To date, most new vaccines against Mycobacterium tuberculosis, including new recombinant versions of the current BCG vaccine, have usually been screened against the laboratory strains H37Rv or Erdman. In this study we took advantage of our recent wor
Externí odkaz:
https://doaj.org/article/35d7ec6e59fa4c74a2359e3546a60ad4
Autor:
Jim Sun, Vijender Singh, Alice Lau, Richard W Stokes, Andrés Obregón-Henao, Ian M Orme, Dennis Wong, Yossef Av-Gay, Zakaria Hmama
Publikováno v:
PLoS Pathogens, Vol 9, Iss 7, p e1003499 (2013)
Defining the mechanisms of Mycobacterium tuberculosis (Mtb) persistence in the host macrophage and identifying mycobacterial factors responsible for it are keys to better understand tuberculosis pathogenesis. The emerging picture from ongoing studies
Externí odkaz:
https://doaj.org/article/7337e941e463468787ed22380ba6d8b9
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e80669 (2013)
Tuberculosis is one of the world's leading killers, stealing 1.4 million lives and causing 8.7 million new and relapsed infections in 2011. The only vaccine against tuberculosis is BCG which demonstrates variable efficacy in adults worldwide. Human i
Externí odkaz:
https://doaj.org/article/f0082fa4173a45f5939507a6c84e36ce
Autor:
Gopinath S Palanisamy, Natalie M Kirk, David F Ackart, Andrés Obregón-Henao, Crystal A Shanley, Ian M Orme, Randall J Basaraba
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e34148 (2012)
The typical host response to infection of humans and some animals by M. tuberculosis is the accumulation of reactive oxygen species generating inflammatory cells into discrete granulomas, which frequently develop central caseous necrosis. In previous
Externí odkaz:
https://doaj.org/article/70494065d5ad4bb6ad2dd0a766bce4e3
Autor:
Gopinath S Palanisamy, Natalie M Kirk, David F Ackart, Crystal A Shanley, Ian M Orme, Randall J Basaraba
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e26254 (2011)
The development of granulomatous inflammation with caseous necrosis is an important but poorly understood manifestation of tuberculosis in humans and some animal models. In this study we measured the byproducts of oxidative stress in granulomatous le
Externí odkaz:
https://doaj.org/article/93f7bf8bdb5c42aa9219efda9820fa1e
Autor:
Joshua E. Drumm, Kaixia Mi, Patrick Bilder, Meihao Sun, Jihyeon Lim, Helle Bielefeldt-Ohmann, Randall Basaraba, Melvin So, Guofeng Zhu, JoAnn M. Tufariello, Angelo A. Izzo, Ian M. Orme, Steve C. Almo, Thomas S. Leyh, John Chan
Publikováno v:
PLoS Pathogens, Vol 5, Iss 9 (2009)
Externí odkaz:
https://doaj.org/article/c0fc356f1d6e4b838d49ad94795b1744