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Oxidation modulates LINGO2-induced inactivation of large conductance, Ca2+-activated potassium channels

Autor: Srikanth Dudem, Pei Xin Boon, Nicholas Mullins, Heather McClafferty, Michael J. Shipston, Richard D.A. Wilkinson, Ian Lobb, Gerard P. Sergeant, Keith D. Thornbury, Irina G. Tikhonova, Mark A. Hollywood

Publikováno v: Dudem, S, Boon, P X, Mullins, N, McClafferty, H, Shipston, M J, Wilkinson, R D A, Lobb, I, Sergeant, G P, Thornbury, K D, Tikhonova, I G & Hollywood, M A 2023, ' Oxidation modulates LINGO2-induced inactivation of large conductance, Ca2 +-activated potassium channels ', The Journal of Biological Chemistry, vol. 299, no. 3, 102975 . https://doi.org/10.1016/j.jbc.2023.102975

Ca 2+ and voltage-activated K + (BK) channels are ubiquitous ion channels that can be modulated by accessory proteins, including β, γ, and LINGO1 BK subunits. In this study, we utilized a combination of site-directed mutagenesis, patch clamp electr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1495f97e0c80f1b57baf1814ccbfd671
https://pure.qub.ac.uk/en/publications/5d33d0e5-f1db-494a-a1d1-cd824ca00826

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A Hibernation-Like State for Transplantable Organs

Autor: Ian Lobb, Robert H. Henning, Alp Sener, Manujendra N. Saha, Hjalmar R. Bouma, George J. Dugbartey

Publikováno v: Anatomy and Cell Biology Publications

Significance: Renal transplantation is the treatment of choice for end-stage renal disease, during which renal grafts from deceased donors are routinely cold stored to suppress metabolic demand and thereby limit ischemic injury. However, prolonged co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b03eb48d0ac1b7dadad3df4343057cbb
https://doi.org/10.1089/ars.2017.7127

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A novel approach to off-clamp partial nephrectomy demonstrates significant improvements in renal injury in an experimental porcine model

Autor: Alp Sener, Ghaleb Aboalsamh, Manujendra N. Saha, Aaron Haig, Daniel Olvera-Posada, Shouzhe Lin, Jaskirandeep Grewal, Ian Lobb

Publikováno v: Canadian Urological Association Journal. 11:E390-5

Introduction: We sought to design a partial nephrectomy (PN) with contralateral total nephrectomy porcine model and assess the underlying mechanisms of ischemia reperfusion injury (IRI) after PN using a novel, clinically approved resection device.Met

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6b9ed421dc3ed57bf6373a7dc8e9c38
https://doi.org/10.5489/cuaj.4305

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Hydrogen sulfide

Autor: George J. Dugbartey, Ian Lobb, Alp Sener, Hjalmar R. Bouma

Publikováno v: Nitric oxide-Biology and chemistry. 57:15-20

Cisplatin is a potent chemotherapeutic agent for the treatment of various solid-organ cancers. However, a plethora of evidence indicates that nephrotoxicity is a major side effect of cisplatin therapy. While the antineoplastic action of cisplatin is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed8a30b08865df2debc7a3a3fbbf9af5
https://doi.org/10.1016/j.niox.2016.04.005

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Hydrogen Sulfide Induced Erythropoietin Synthesis is Regulated by HIF Proteins

Autor: Amy Mok, Rui Wang, Jennifer Leigh, Alp Sener, Manujendra N. Saha, Ian Lobb, Omar Champsi

Publikováno v: Journal of Urology. 196:251-260

Anemia of end stage renal disease affects 90% of patients on hemodialysis and it is a tremendous concern of patients and health care providers. Renal disease creates a state of renal hypoxia, which may contribute to a lack of erythropoietin productio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03e11769d78e9de1eadf689cc3906eb7
https://doi.org/10.1016/j.juro.2016.01.113

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Endogenous H2S production deficiencies lead to impaired renal erythropoietin production

Autor: Peng Shao, Martin Feelisch, Rui Wang, Jennifer Leigh, Matthias Bachtler, Alp Sener, Masoud Akbari, Zhongming Qian, Bernadette O. Fernandez, Harry van Goor, Andreas Pasch, Smriti Juriasingani, Ian Lobb, Manujendra N. Saha

Publikováno v: Canadian Urological Association journal = Journal de l'Association des urologues du Canada, 13(7), E210-E219. CANADIAN UROLOGICAL ASSOCIATION

INTRODUCTION: Patients suffering from chronic kidney disease (CKD) experience a number of associated comorbidities, including anemia. Relative deficiency in renal erythropoietin (EPO) production is thought to be a primary cause of anemia. Interesting

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5275513f1ef704963bb57c20b54d428b
https://doi.org/10.5489/cuaj.5658

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Daily Therapy with a Slow-releasing H2S Donor GYY4137 Enables Early Functional Recovery and Ameliorates Renal Injury Associated with Urinary Obstruction

Autor: Matthew Whiteman, Shouzhe Lin, Jeremy P. Burton, Hassan Razvi, Aaron Haig, Weihua Liu, Alp Sener, Dameng Lian, Ahmed Hijazi, Ian Lobb

Publikováno v: Anatomy and Cell Biology Publications

Objectives: To assess the effects of slow-releasing H2S donor GYY4137 on post-obstructive renal function and injury following unilateral ureteral obstruction (UUO) by using the UUO and reimplantation (UUO-R) model in rats and to elucidate potential m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9f47320335b240a857c00581800b953
https://ir.lib.uwo.ca/anatomypub/132

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Inhibition of endogenous hydrogen sulfide production in clear-cell renal cell carcinoma cell lines and xenografts restricts their growth, survival and angiogenic potential

Autor: Nicholas Power, Matthew D. Hammers, Siddika Pardhan, Ann F. Chambers, Hon S. Leong, Megan Verrydt, Carl O. Postenka, Alp Sener, Ian Lobb, Chantalle J. Willie, Clarisse R. Mazzola, Michael D. Pluth, Eric Sonke

Publikováno v: Nitric Oxide. 49:26-39

Clear cell renal cell carcinoma (ccRCC) is characterized by Von Hippel-Lindau (VHL)-deficiency, resulting in pseudohypoxic, angiogenic and glycolytic tumours. Hydrogen sulfide (H2S) is an endogenously-produced gasotransmitter that accumulates under h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a7a4434ab191268d96bd246c1fd303e
https://doi.org/10.1016/j.niox.2015.06.001

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Hydrogen Sulfide Protects Renal Grafts Against Prolonged Cold Ischemia-Reperfusion Injury via Specific Mitochondrial Actions

Autor: Manujendra N. Saha, Jifu Jiang, Alp Sener, Roberta Torregrossa, Matthew Whiteman, Dameng Lian, Ian Lobb, W. Liu, Mark E. Wood, Aaron Haig

Publikováno v: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 17(2)

Ischemia-reperfusion injury is unavoidably caused by loss and subsequent restoration of blood flow during organ procurement, and prolonged ischemia-reperfusion injury IRI results in increased rates of delayed graft function and early graft loss. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cfb5e48c9b0196555c07b9d97169788
https://pubmed.ncbi.nlm.nih.gov/27931079

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