Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Ian Ladran"'
Autor:
Gabriel E. Hoffman, Brigham J. Hartley, Erin Flaherty, Ian Ladran, Peter Gochman, Douglas M. Ruderfer, Eli A. Stahl, Judith Rapoport, Pamela Sklar, Kristen J. Brennand
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Induced pluripotent stem cell (hiPSC)-based models have inherent variations in their cellular and molecular output and readouts. Here, Hoffman and colleagues devise a method to account for gene expression variations in hiPSC-derived neurons from pati
Externí odkaz:
https://doaj.org/article/99c9b01d94b044f2bf2ad26960baaf9f
Autor:
Michael B. Fernando, Natalie Barretto, Kristen J. Brennand, Nadine Schrode, Esther Cheng, Robert Sebra, Gintaras Deikus, Megan L. Fitzgerald, Robert E. McCullumsmith, Erin Flaherty, P J Michael Deans, Peter Gochman, Nancy Francoeur, Judith L. Rapoport, Hardik Shah, Ian Ladran, Alesia Antoine, Nadejda M. Tsankova, Shijia Zhu, Gabriel E. Hoffman, Madeline Halpern, Khaled Alganem, Gang Fang
Publikováno v:
Nature genetics
NRXN1 undergoes extensive alternative splicing, and non-recurrent heterozygous deletions in NRXN1 are strongly associated with neuropsychiatric disorders. We establish that human induced pluripotent stem cell (hiPSC)-derived neurons represent well th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a3153c7be8dda7f8bace71c6942e6be
https://pubmed.ncbi.nlm.nih.gov/31784728
https://pubmed.ncbi.nlm.nih.gov/31784728
Autor:
Eli A. Stahl, Gabriel E. Hoffman, Douglas M. Ruderfer, Brigham J. Hartley, Pamela Sklar, Kristen J. Brennand, Peter Gochman, Erin Flaherty, Judith L. Rapoport, Ian Ladran
Whereas highly penetrant variants have proven well-suited to human induced pluripotent stem cell (hiPSC)-based models, the power of hiPSC-based studies to resolve the much smaller effects of common variants within the size of cohorts that can be real
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38eed9ea6f275007f3655bf2f5c90707
Autor:
Kristin G. Beaumont, Kristen J. Brennand, Ngoc Tran, Yongsung Kim, Aaron Topol, M. Abdelrahim, Hyung J. Kim, Shih-hui Chao, Anthony Simone, Milan Mrksich, Gang Fang, Bin Zhang, Jeffrey N. Savas, Fred H. Gage, Pasko Rakic, Ian Ladran, Kazue Hashimoto-Torii, B. Matikainen-Ankney, John R. Yates
Publikováno v:
Molecular Psychiatry
Consistent with recent reports indicating that neurons differentiated in vitro from human-induced pluripotent stem cells (hiPSCs) are immature relative to those in the human brain, gene expression comparisons of our hiPSC-derived neurons to the Allen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46a24595cb92d1732baaa27cc0754cdb
http://europepmc.org/articles/PMC4182344
http://europepmc.org/articles/PMC4182344
Autor:
Gabriel E. Hoffman, Doug Ruderfer, Erin Flaherty, Kristen J. Brennand, Brigham J. Hartley, Peter Gochman, Pamela Sklar, Judith L. Rapoport, Ian Ladran
Publikováno v:
European Neuropsychopharmacology. 29:S1008
Background Large-scale Genome Wide Association Studies (GWAS) revealed that Schizophrenia (SZ) risk reflects both rare and common variants. Whereas highly penetrant rare variants have proven well-suited to human induced pluripotent stem cell (hiPSC)-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::656ec4db47c70681140bddf018069144
https://doi.org/10.1016/j.euroneuro.2017.08.404
https://doi.org/10.1016/j.euroneuro.2017.08.404
Publikováno v:
Schizophrenia Bulletin. 39:4-10
Although schizophrenia affects a number of brain regions and produces a range of clinical symptoms, we believe its origins lie at the level of single neurons and simple networks. Owing to this, as well as to its high degree of heritability, we hypoth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc94e8a1df30a4aa635fb4d1177ad06b
https://doi.org/10.1093/schbul/sbs127
https://doi.org/10.1093/schbul/sbs127
Publikováno v:
Molecular psychiatry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abab862bad82fa87b1486b11dfd782da
https://doi.org/10.1038/mp.2014.194
https://doi.org/10.1038/mp.2014.194
Publikováno v:
Wiley interdisciplinary reviews. Systems biology and medicine. 5(6)
Neural stem/progenitor cells (NSPCs) have the potential to differentiate into neurons, astrocytes, and/or oligodendrocytes. Because these cells can be expanded in culture, they represent a vast source of neural cells. With the recent discovery that p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ed51b713d314c2c7428cd99b90d847a
https://pubmed.ncbi.nlm.nih.gov/24068527
https://pubmed.ncbi.nlm.nih.gov/24068527
Autor:
Shane McCarthy, Seok-Man Ho, Deborah L. Levy, James R. Lupski, Judith L. Rapoport, Ian Ladran, Claudia M.B. Carvalho, Inkyu S. Lee, Jonathan Sebat, Luciana W. Zuccherato, Brigham J. Hartley, Kristen J. Brennand, Arthur J. Siegel, Dheeraj Malhotra, Valentina Fossati, Panagiotis Douvaras
Publikováno v:
ResearcherID
Neurodevelopmental disorders, such as autism spectrum disorders and schizophrenia, are complex disorders with a high degree of heritability. Genetic studies have identified several candidate genes associated with these disorders, including contactin-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0b5870a0748af08c45dd73eb8dab056
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=MEDLINE&KeyUT=MEDLINE:26985448&KeyUID=MEDLINE:26985448
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=MEDLINE&KeyUT=MEDLINE:26985448&KeyUID=MEDLINE:26985448