Zobrazeno 1 - 10
of 196
pro vyhledávání: '"Ian L. Sargent"'
Autor:
Chris Gardiner, Michael Shaw, Patrick Hole, Jonathan Smith, Dionne Tannetta, Christopher W. Redman, Ian L. Sargent
Publikováno v:
Journal of Extracellular Vesicles, Vol 3, Iss 0, Pp 1-6 (2014)
Introduction: Optical techniques are routinely used to size and count extracellular vesicles (EV). For comparison of data from different methods and laboratories, suitable calibrators are essential. A suitable calibrator must have a refractive index
Externí odkaz:
https://doaj.org/article/32bd0bf9e6e94d148862f0f25ad2042b
Autor:
Christopher W.G. Redman, Ian L. Sargent, Rebecca A. Dragovic, Yannick J. Ferreira, Chris Gardiner
Publikováno v:
Journal of Extracellular Vesicles, Vol 2, Iss 0, Pp 1-11 (2013)
Nanoparticle tracking analysis (NTA) is a light-scattering technique that is useful for the rapid sizing and enumeration of extracellular vesicles (EVs). As a relatively new method, NTA has been criticised for a lack of standardisation. We propose th
Externí odkaz:
https://doaj.org/article/2127c75855db419e95ed0251d8e205b6
Autor:
Lydia Alvarez-Erviti, Yiqi Seow, Anthony H. Schapira, Chris Gardiner, Ian L. Sargent, Matthew J.A. Wood, J. Mark Cooper
Publikováno v:
Neurobiology of Disease, Vol 42, Iss 3, Pp 360-367 (2011)
Alpha-synuclein aggregation plays a central role in Parkinson's disease pathology. Direct transmission of alpha-synuclein from pathologically affected to healthy unaffected neurons may be important in the anatomical spread of the disease through the
Externí odkaz:
https://doaj.org/article/79b853eac4d742388db9651233b23095
Autor:
Floor Spaans, Cindy K Kao, Jude S Morton, Anita L Quon, Tatsuya Sawamura, Dionne S Tannetta, Ian L Sargent, Sandra T Davidge
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0180364 (2017)
Syncytiotrophoblast extracellular vesicles (STBEVs) are placenta derived particles that are released into the maternal circulation during pregnancy. Abnormal levels of STBEVs have been proposed to affect maternal vascular function. The lectin-like ox
Externí odkaz:
https://doaj.org/article/462a1a2e5c11427aa48814df7107ec27
Autor:
Dionne S Tannetta, Kathryn Hunt, Chris I Jones, Naomi Davidson, Carmen H Coxon, David Ferguson, Christopher W Redman, Jonathan M Gibbins, Ian L Sargent, Katherine L Tucker
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0142538 (2015)
Pre-eclampsia (PE) complicates around 3% of all pregnancies and is one of the most common causes of maternal mortality worldwide. The pathophysiology of PE remains unclear however its underlying cause originates from the placenta and manifests as rai
Externí odkaz:
https://doaj.org/article/78a2228d935e4f48ba14fae97ace37d0
Autor:
Dionne Tannetta, Michiya Matsusaki, Paul Verkade, Simon Grant, John D. Aplin, Gavin Collett, Jon Hanley, Aman Sood, Fiona Day, Nagaraj D. Halemani, Catherine Murdoch-Davis, Akihiro Nishiguchi, Jennifer McGarvey, Ian L. Sargent, Helena Kemp, Mitsuru Akashi, Catherine E. Gilmore, C. Patrick Case
Publikováno v:
Biomaterials. 192:140-148
Fetal development may be compromised by adverse events at the placental interface between mother and fetus. However, it is still unclear how the communication between mother and fetus occurs through the placenta. In vitro - models of the human placen
Autor:
Tina Cronqvist, Karen Saljé, Mary Familari, Seth Guller, Henning Schneider, Chris Gardiner, Ian L Sargent, Christopher W Redman, Matthias Mörgelin, Bo Åkerström, Magnus Gram, Stefan R Hansson
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e90020 (2014)
Cell-free foetal haemoglobin (HbF) has been shown to play a role in the pathology of preeclampsia (PE). In the present study, we aimed to further characterize the harmful effects of extracellular free haemoglobin (Hb) on the placenta. In particular,
Externí odkaz:
https://doaj.org/article/dc1b25d0e1764bb7919121ddeba0f4af
Autor:
Floor Spaans, Jude S. Morton, Dionne Tannetta, Tatsuya Sawamura, Sandra T. Davidge, Ian L. Sargent, Raven Kirschenman, Stewart Rowe, Anita Quon
Publikováno v:
Clinical Science. 132:2369-2381
Syncytiotrophoblast extracellular vesicles (STBEVs), released into the maternal circulation during pregnancy, have been shown to affect vascular function; however, the mechanism remains unknown. In rats, STBEVs were shown to reduce endothelium-mediat
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e56754 (2013)
The placental syncytiotrophoblast releases micro and nanovesicles (STBM), into the maternal circulation in normal pregnancy and in increased amounts in pre-eclampsia (PE), which have proinflammatory and antiangiogenic activity and are implicated in P
Externí odkaz:
https://doaj.org/article/717d2fe75c594ad1bf19ed4740871d3a
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e30453 (2012)
Fusion of placental villous cytotrophoblasts with the overlying syncytiotrophoblast is essential for the maintenance of successful pregnancy, and disturbances in this process have been implicated in pathological conditions such as pre-eclampsia and i
Externí odkaz:
https://doaj.org/article/ee67d923f2554940a61c1d9b661ef9b2