Zobrazeno 1 - 10
of 186
pro vyhledávání: '"Ian L Megson"'
Publikováno v:
PLoS ONE, Vol 17, Iss 5, p e0267675 (2022)
Hyperglycaemia is known to induce endothelial dysfunction and changes in metabolic function, which could be implicated in diabetes-induced cardiovascular disease. To date, however, little is known about the impact of physiologically relevant concentr
Externí odkaz:
https://doaj.org/article/bedbab2bdcaf47969a7032a63266e13e
Autor:
Andrew T Treweeke, Benjamin H Maskrey, Kirsty Hickson, John H Miller, Stephen J Leslie, Ian L Megson
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0147196 (2016)
BACKGROUND:There is no consensus and a limited evidence base for choice of contrast agents (CA) in angiography. This study evaluated the impact of iohexol and iodixanol CA on fibrinolytic factors (tissue plasminogen activator [t-PA] and plasminogen a
Externí odkaz:
https://doaj.org/article/0e6d175bec6644fa91f3ca308c44a708
Autor:
Katarzyna eGoszcz, Sherine J Deakin, Garry G Duthie, Derek eStewart, Stephen James Leslie, Ian L Megson
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 2 (2015)
Oxidative stress is a key feature of the atherothrombotic process involved in the aetiology of heart attacks, ischaemic strokes and peripheral arterial disease. It stands to reason that antioxidants represent a credible therapeutic option to prevent
Externí odkaz:
https://doaj.org/article/6f18b706071f423dbc679b33a299c977
Publikováno v:
Memorias do Instituto Oswaldo Cruz, Vol 100, Pp 67-71 (2005)
The ubiquitous free radical, nitric oxide (NO), plays an important role in many biological processes including the regulation of the inflammatory response. Alterations in NO synthesis by endogenous systems likely influence inflammatory processes occu
Externí odkaz:
https://doaj.org/article/407086dbd5f14864b3791ca7d15a15da
Autor:
Chun Ye, Yan Ruan, Liying Zou, Guanghui Li, Changdong Li, Yi Chen, Chaoxia Jia, Ian L Megson, Jun Wei, Weiyuan Zhang
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e100180 (2014)
Hypertensive disorders of pregnancy (HDP) are a group of medical complications in pregnancy and also a risk factor for severe pregnancy outcomes, but it lacks a large-scale epidemiological investigation in recent years. This survey represents a multi
Externí odkaz:
https://doaj.org/article/c96cf5b29c7946ed8b9273f2403fb003
Publikováno v:
BJA Open, Vol 10, Iss , Pp 100292- (2024)
Background: Intravenous lipid emulsion is recognised as a therapy for rescue in cases of local anaesthetic toxicity, but its use in reversing overdose or toxicity related to other drugs remains the subject of debate. This in vitro study sought to exp
Externí odkaz:
https://doaj.org/article/71fbfc6c5a864cb5b51fc4ca9d4695b9
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e81209 (2013)
OBJECTIVE: To determine whether exposure to environmental tobacco smoke was associated with oxidative stress among patients hospitalised for acute myocardial infarction. DESIGN: An existing cohort study of 1,261 patients hospitalised for acute myocar
Externí odkaz:
https://doaj.org/article/e84d938f901549adb341149b582bf398
Publikováno v:
Journal of Inflammation, Vol 19, Iss 1, Pp 1-19 (2022)
Abstract Background Macrophages play a central role in inflammation by phagocytosing invading pathogens, apoptotic cells and debris, as well as mediating repair of tissues damaged by trauma. In order to do this, these dynamic cells generate a variety
Externí odkaz:
https://doaj.org/article/6819e66a7d6c4ab794f30ff4d58d38a7
Autor:
Euan A. Sandilands, Jessica M. B. Rees, Khuram Raja, Neeraj Dhaun, Emma E. Morrison, Kirsty Hickson, Jonathan Wraight, Tanya Gray, Lesley Briody, Sharon Cameron, Adrian P. Thompson, Neil R. Johnston, Neal Uren, Jane Goddard, Andy Treweeke, Gordon Rushworth, David J. Webb, D. Nicholas Bateman, John Norrie, Ian L. Megson, Michael Eddleston
Publikováno v:
Sandilands, E A, Rees, J MB, Raja, K, Dhaun, N, Morrison, E E, Hickson, K, Wraight, J, Gray, T, Briody, L, Cameron, S, Thompson, A P, Johnston, N R, Uren, N, Goddard, J, Treweeke, A, Rushworth, G, Webb, D J, Bateman, N, Norrie, J, Megson, I & Eddleston, M 2022, ' Acetylcysteine has No Mechanistic Effect in Patients at Risk of Contrast-Induced Nephropathy-A Failure of Academic Clinical Science ', Clinical pharmacology and therapeutics . https://doi.org/10.1002/cpt.2541
Contrast-induced nephropathy (CIN) is a major complication of imaging in patients with chronic kidney disease (CKD). The publication of an academic randomized controlled trial (RCT; n = 83) reporting oral (N)-acetylcysteine (NAC) to reduce CIN led to
Autor:
Denise Burtenshaw, Brian Regan, Kathryn Owen, David Collins, David McEneaney, Ian L. Megson, Eileen M. Redmond, Paul Aidan Cahill
Publikováno v:
Burtenshaw, Denise ORCID: 0000-0002-5958-1773 , Regan, Brian ORCID: 0000-0002-7410-4748 , Owen, Kathryn ORCID: 0000-0002-0859-1525 , Collins, David, McEneaney, David ORCID: 0000-0002-1734-0736 , Megson, Ian L. ORCID: 0000-0001-8287-2459 , Redmond, Eileen M. ORCID: 0000-0001-8642-4418 and Cahill, Paul A. ORCID: 0000-0002-5385-6502 (2022) Exosomal composition, biogenesis and profiling using point-of-care diagnostics—Implications for cardiovascular disease. Frontiers in Cell and Developmental Biology, 10 . ISSN 2296-634X
Arteriosclerosis is an important age-dependent disease that encompasses atherosclerosis, in-stent restenosis (ISR), pulmonary hypertension, autologous bypass grafting and transplant arteriosclerosis. Endothelial dysfunction and the proliferation of v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bd90d130f84ececab867ce699a30c21
http://doras.dcu.ie/27797/
http://doras.dcu.ie/27797/