An in vitro study to determine the impact of lipid emulsion on partitioning of a broad spectrum of drugs associated with overdose

Autor: Kenneth Barker, Michael Stewart, Alison Rutter, Phillip D. Whitfield, Ian L. Megson

Publikováno v: BJA Open, Vol 10, Iss , Pp 100292- (2024)

Background: Intravenous lipid emulsion is recognised as a therapy for rescue in cases of local anaesthetic toxicity, but its use in reversing overdose or toxicity related to other drugs remains the subject of debate. This in vitro study sought to exp

Externí odkaz: https://doaj.org/article/71fbfc6c5a864cb5b51fc4ca9d4695b9

Exosomal Composition, Biogenesis and Profiling Using Point-of-Care Diagnostics—Implications for Cardiovascular Disease

Autor: Denise Burtenshaw, Brian Regan, Kathryn Owen, David Collins, David McEneaney, Ian L. Megson, Eileen M. Redmond, Paul Aidan Cahill

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 10 (2022)

Arteriosclerosis is an important age-dependent disease that encompasses atherosclerosis, in-stent restenosis (ISR), pulmonary hypertension, autologous bypass grafting and transplant arteriosclerosis. Endothelial dysfunction and the proliferation of v

Externí odkaz: https://doaj.org/article/576c5cfbd4c64084b2e96667d7d0adf4

Why Is COVID-19 More Severe in Patients With Diabetes? The Role of Angiotensin-Converting Enzyme 2, Endothelial Dysfunction and the Immunoinflammatory System

Autor: Jacob Roberts, Antonia L. Pritchard, Andrew T. Treweeke, Adriano G. Rossi, Nicole Brace, Paul Cahill, Sandra M. MacRury, Jun Wei, Ian L. Megson

Publikováno v: Frontiers in Cardiovascular Medicine, Vol 7 (2021)

Meta-analyses have indicated that individuals with type 1 or type 2 diabetes are at increased risk of suffering a severe form of COVID-19 and have a higher mortality rate than the non-diabetic population. Patients with diabetes have chronic, low-leve

Externí odkaz: https://doaj.org/article/e4d19da3f65c4aa385364ac7be78b67c

Co-ingestion of Antioxidant Drinks With an Unhealthy Challenge Meal Fails to Prevent Post-prandial Endothelial Dysfunction: An Open-Label, Crossover Study in Older Overweight Volunteers

Autor: David J. Muggeridge, Katarzyna Goszcz, Andrew Treweeke, Janet Adamson, Kirsty Hickson, Daniel Crabtree, Ian L. Megson

Publikováno v: Frontiers in Physiology, Vol 10 (2019)

Eating a high calorie meal is known to induce endothelial dysfunction and it is reported that consuming drinks rich in antioxidants may be protective against this. In this study we assessed the effects of three antioxidant drinks with considerable di

Externí odkaz: https://doaj.org/article/ad9715fd85f240df9c8d4a082d018acf

Acetylcysteine has No Mechanistic Effect in Patients at Risk of Contrast‐Induced Nephropathy: A Failure of Academic Clinical Science

Autor: Euan A. Sandilands, Jessica M. B. Rees, Khuram Raja, Neeraj Dhaun, Emma E. Morrison, Kirsty Hickson, Jonathan Wraight, Tanya Gray, Lesley Briody, Sharon Cameron, Adrian P. Thompson, Neil R. Johnston, Neal Uren, Jane Goddard, Andy Treweeke, Gordon Rushworth, David J. Webb, D. Nicholas Bateman, John Norrie, Ian L. Megson, Michael Eddleston

Publikováno v: Sandilands, E A, Rees, J MB, Raja, K, Dhaun, N, Morrison, E E, Hickson, K, Wraight, J, Gray, T, Briody, L, Cameron, S, Thompson, A P, Johnston, N R, Uren, N, Goddard, J, Treweeke, A, Rushworth, G, Webb, D J, Bateman, N, Norrie, J, Megson, I & Eddleston, M 2022, ' Acetylcysteine has No Mechanistic Effect in Patients at Risk of Contrast-Induced Nephropathy-A Failure of Academic Clinical Science ', Clinical pharmacology and therapeutics . https://doi.org/10.1002/cpt.2541

Contrast-induced nephropathy (CIN) is a major complication of imaging in patients with chronic kidney disease (CKD). The publication of an academic randomized controlled trial (RCT; n = 83) reporting oral (N)-acetylcysteine (NAC) to reduce CIN led to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf68dc214969b61a07ee0f99e8a36c71
https://doi.org/10.1002/cpt.2541