Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Ian J. Thomas"'
Autor:
Antonis K. Moustakas, George K. Papadopoulos, Liliana G. Petrich de Marquesini, Ian J. Thomas, F. Susan Wong, Li Wen
Publikováno v:
European Journal of Immunology
Insulin-reactive CD8 T cells are amongst the earliest islet-infiltrating CD8 T cells in NOD mice. Cloned insulin B15-23-reactive cells (designated G9C8), restricted by H-2K(d), are highly diabetogenic. We used altered peptide ligands (APL) substitute
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ceddb95a653a4ae7cf08aad7a1e7630c
https://doi.org/10.1002/eji.200737762
https://doi.org/10.1002/eji.200737762
Autor:
F. Susan Wong, Sylvie Guerder, Ian J. Thomas, David C. Wraith, Richard M. Smith, Richard A. Flavell, Liliana G. Petrich de Marquesini, Li Wen, Rommel Ravanan
Publikováno v:
The Journal of Immunology. 179:5936-5946
CD80 and CD86 both costimulate T cell activation. Their individual effects in vivo are difficult to study as they are coordinately up-regulated on APCs. We have studied mice expressing rat insulin promoter (RIP)-CD80 and RIP-CD86 on the NOD and NOD.s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d60d8558b2230066282302c1d998685a
https://doi.org/10.4049/jimmunol.179.9.5936
https://doi.org/10.4049/jimmunol.179.9.5936
Publikováno v:
Diabetes. 54:2032-2040
The most important genetic susceptibility factor for type 1 diabetes is encoded in the major histocompatibility complex (MHC). The nonobese diabetic (NOD) mouse, which develops spontaneous diabetes, expresses H-2 g7 comprising the MHC class I molecul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87bdcbe0a20f3c1bf97556243d09d09f
https://doi.org/10.2337/diabetes.54.7.2032
https://doi.org/10.2337/diabetes.54.7.2032
Autor:
Li Wen, Stephen Chapman, Christopher Viret, Florence Susan Wong, Lai Khai Siew, Gwen S. Scott, Ian J. Thomas
Publikováno v:
Diabetes
OBJECTIVE We have previously reported a highly diabetogenic CD8 T-cell clone, G9C8, in the nonobese diabetic (NOD) mouse, specific to low-avidity insulin peptide B15-23, and cells responsive to this antigen are among the earliest islet infiltrates. W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e6c454c987d57fb5d253a88e55c81fd
https://pubmed.ncbi.nlm.nih.gov/19208910
https://pubmed.ncbi.nlm.nih.gov/19208910
Publikováno v:
The Journal of Immunology. 178:S227-S227
We have previously generated highly diabetogenic insulin-reactive CD8 T cell clones designated G9C8 from the NOD mouse. The aim of our study was to investigate T cell selection and activation of CD8 T cells from a TCR transgenic mouse expressing the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c056190b516555f205b4340b30d14f4a
https://doi.org/10.4049/jimmunol.178.supp.129.46
https://doi.org/10.4049/jimmunol.178.supp.129.46