Zobrazeno 1 - 10
of 145
pro vyhledávání: '"Ian J. Molineux"'
Publikováno v:
Cells, Vol 13, Iss 7, p 585 (2024)
Recombination among different phages sometimes facilitates their ability to grow on new hosts. Protocols to direct the evolution of phage host range, as might be used in the application of phage therapy, would then benefit from including steps to ena
Externí odkaz:
https://doaj.org/article/a0271e3f8b964e79abf59746515a637a
Autor:
Michal R. Szymanski, Wangsheng Yu, Aleksandra M. Gmyrek, Mark A. White, Ian J. Molineux, J. Ching Lee, Y. Whitney Yin
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Human EXOG is crucial for mitochondrial DNA repair. Here the authors present the crystal structures of hEXOG in apo form and as DNA complex and suggest a `tape-measure' activity to generate optimal substrates for mitochondrial base excision repair.
Externí odkaz:
https://doaj.org/article/69b2fef277bd4fcea402f22d42c7215c
Publikováno v:
Viruses, Vol 11, Iss 12, p 1083 (2019)
Phage therapy is the use of bacterial viruses (phages) to treat bacterial infections, a medical intervention long abandoned in the West but now experiencing a revival. Currently, therapeutic phages are often chosen based on limited criteria, sometime
Externí odkaz:
https://doaj.org/article/d080ec3925dd4fe382bf72507dac65ac
Publikováno v:
PeerJ, Vol 6, p e5190 (2018)
The dsDNA bacteriophage T7 was subjected to 30 cycles of lethal ultraviolet light (UV) exposure to select increased resistance to UV. The exposure effected a 0.9999 kill of the ancestral population, and survival of the ending population was nearly 50
Externí odkaz:
https://doaj.org/article/f726f2e9760b403c81bcbd3a656c946b
Publikováno v:
Frontiers in Microbiology, Vol 8 (2017)
Capsule depolymerase enzymes offer a promising class of new antibiotics. In vivo studies are encouraging but it is unclear how well this type of phage product will generalize in therapeutics, or whether different depolymerases against the same capsul
Externí odkaz:
https://doaj.org/article/2deb309e886c424da8be64a0bca97e97
Publikováno v:
Viruses, Vol 11, Iss 3, p 241 (2019)
The ‘Appelmans protocol’ is used by Eastern European researchers to generate therapeutic phages with novel lytic host ranges. Phage cocktails are iteratively grown on a suite of mostly refractory bacterial isolates until the evolved cocktail can
Externí odkaz:
https://doaj.org/article/84f0509ba1cc44e8bdaff8ec08322a69
Publikováno v:
Viruses, Vol 10, Iss 11, p 622 (2018)
Phage-derived depolymerases directed against bacterial capsules are showing therapeutic promise in various animal models of infection. However, individual animal model studies are often constrained by use of highly specific protocols, such that resul
Externí odkaz:
https://doaj.org/article/fd8c24c3af0d4824800244d889af39c3
Publikováno v:
PeerJ, Vol 4, p e2166 (2016)
The failure of traditional interventions to block and cure HIV infections has led to novel proposals that involve treating infections with therapeutic viruses–infectious viruses that specifically inhibit HIV propagation in the host. Early efforts i
Externí odkaz:
https://doaj.org/article/a1497ab019d74eab81e99e3a9c8951dc
Publikováno v:
PeerJ, Vol 2, p e590 (2014)
Where phages are used to treat bacterial contaminations and infections, multiple phages are typically applied at once as a cocktail. When two or more phages in the cocktail attack the same bacterium, the combination may produce better killing than an
Externí odkaz:
https://doaj.org/article/6d72172ff0394a0189b8d46df2cf88e6
Publikováno v:
Nature microbiology
For successful infection, bacteriophages must overcome multiple barriers to transport their genome and proteins across the bacterial cell envelope. We use cryo-electron tomography to study the infection initiation of phage P22 in Salmonella enterica